11 research outputs found
Reduction of Pd2+ pre-adsorbed on cyanide-modified Pt(111) electrodes : adlayer metallization vs. metal-on-metal deposition
Acknowledgement The support of the University of Aberdeen is gratefully acknowledged.Peer reviewedPostprin
Metallization of cyanide-modified Pt(111) electrodes with copper
The support of the University of Aberdeen is gratefully acknowledged. CW acknowledges a summer studentship from the Carnegie Trust for the Universities of Scotland.Peer reviewedPostprin
Electrochemical Metallization of Molecular Adlayers
Acknowledgements Continuous support from the University of Aberdeen is gratefully acknowledged.Peer reviewedPostprin
Mapping the electronic structure of polypyrrole with image-based electrochemical scanning tunneling spectroscopy
ACKNOWLEDGMENTS The support of this research by FAPESP (grants: 2013/07296-2, 2014/50249-8, 2015/12851-0, 2017/11986-5), Shell, CsF-PVE (99999.007708/2015-07), Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior - Brasil (CAPES) - Finance Code 001 and CNPq is gratefully acknowledged.Peer reviewedPublisher PD
Mapping the Electronic Structure of Polypyrrole with Image-Based Electrochemical Scanning Tunnelling Spectroscopy
Conducting
polymers are versatile semiconductors whose applications cover a wide range of
devices. Their versatility is due, in addition to other factors, to properties that
can be easily modulated according to the intended application. It is therefore important
to study and map the electronic structure of these materials to allow for a
better correlation between structure and properties. Electrochemical scanning
tunnelling spectroscopy (EC-STS) can be a powerful tool to characterize the electronic
structure of the semiconductor electrolyte interface. In this work we have used
image-based EC-STS (IB-EC-STS) to describe quantitatively the band structure of
an electrochemically deposited polypyrrole (PPy) film. IB-EC-STS located the
band edge of the polymerâs valence band (VB) at 0.95 V vs. RHE (-5.33 eV in the
absolute potential scale) and the intragap polaron states formed when the
polymer is oxidised (doped) at 0.46 V vs. RHE (-4.84 eV in the absolute
potential scale). The IB-EC-STS data were cross checked with electrochemical
impedance spectroscopy (EIS) and Mott-Schottky analysis of the interfacial
capacitance. The DOS spectrum obtained from EIS data is consistent with the
STS-deduced location of the VB and the polarons
Excellent clinical outcomes and retention in care for adults with HIV-associated Kaposi sarcoma treated with systemic chemotherapy and integrated antiretroviral therapy in rural Malawi
Introduction: HIV-associated Kaposi sarcoma (HIV-KS) is the most common cancer in Malawi. In 2008, the non-governmental organization, Partners In Health, and the Ministry of Health established the Neno Kaposi Sarcoma Clinic (NKSC) to treat HIV-KS in rural Neno district. We aimed to evaluate 12-month clinical outcomes and retention in care for HIV-KS patients in the NKSC, and to describe our implementation model, which featured protocol-guided chemotherapy, integrated antiretroviral therapy (ART) and psychosocial support delivered by community health workers. Methods: We conducted a retrospective cohort study using routine clinical data from 114 adult HIV-KS patients who received ART and â„1 chemotherapy cycle in the NKSC between March 2008 and February 2012. Results: At enrolment 97% of patients (n/N=103/106) had advanced HIV-KS (stage T1). Most patients were male (n/N=85/114, 75%) with median age 36 years (interquartile range, IQR: 29â42). Patients started ART a median of 77 days prior to chemotherapy (IQR: 36â252), with 97% (n/N=105/108) receiving nevirapine/lamivudine/stavudine. Following standardized protocols, we treated 20 patients (18%) with first-line paclitaxel and 94 patients (82%) with bleomycin plus vincristine (BV). Of the 94 BV patients, 24 (26%) failed to respond to BV requiring change to second-line paclitaxel. A Division of AIDS grade 3/4 adverse event occurred in 29% of patients (n/N=30/102). Neutropenia was the most common grade 3/4 event (n/N=17/102, 17%). Twelve months after chemotherapy initiation, 83% of patients (95% CI: 74â89%) were alive, including 88 (77%) retained in care. Overall survival (OS) at 12 months did not differ by initial chemotherapy regimen (p=0.6). Among patients with T1 disease, low body mass index (BMI) (adjusted hazard ratio, aHR=4.10, 95% CI: 1.06â15.89) and 1 g/dL decrease in baseline haemoglobin (aHR=1.52, 95% CI: 1.03â2.25) were associated with increased death or loss to follow-up at 12 months. Conclusions: The NKSC model resulted in infrequent adverse events, low loss to follow-up and excellent OS. Our results suggest it is safe, effective and feasible to provide standard-of-care chemotherapy regimens from the developed world, integrated with ART, to treat HIV-KS in rural Malawi. Baseline BMI and haemoglobin may represent important patient characteristics associated with HIV-KS survival in rural sub-Saharan Africa