DE genes determined by limma pairwise visit comparison.

<p>DE was pronounced at a BH-adjusted p-value < 0.05 and >1.5 fold expression change. (a) DE genes (red: up-regulated genes, blue: down-regulated genes) identified for each tested contrast are visualized as bars. The number of DE genes per contrast is indicated and additionally emphasized by the length of the bars. The bar width / x-axis indicates the log2 fold expression change of each DE gene. The Venn diagrams display the overlaps between (b) all DE genes of contrasts 5/0 and 9/5, (c) the 5/0 up-regulated and 9/5 down-regulated DE genes and (d) the 5/0 down-regulated and 9/5 up-regulated DE genes.</p

Volunteer gene expression trends visualized as boxplots.

<p>Gene expression trends are shown for two differentially expressed BTMs and one gene set linked to parasitemia. Boxplots with gene-wise baseline-subtracted expression values are shown separately for subjects with early (red), average (green) and late (blue) detection of blood stage parasitemia.</p

GSEA using camera (limma), visualized as heatmap.

<p>Statistical significance is pronounced at a p-value and FDR < 0.05. Red: up-regulated, blue: down-regulated.</p

Volunteer gene expression trends visualized as heatmaps.

<p>Gene expression trends are shown for two differentially expressed BTMs and one gene set linked to parasitemia. Gene-wise expression levels of the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0199392#pone.0199392.g004" target="_blank">Fig 4</a> DE modules are visualized as heatmap. Column color bars indicate grouping of subjects into early (red), average (green) and late (blue) group, based on time point of parasitemia detection. Each row corresponds to one gene.</p