2 research outputs found
One-carbon metabolism and nonalcoholic fatty liver disease: The crosstalk between nutrients, microbiota, and genetics
The prevalence of nonalcoholic fatty liver disease (NAFLD) is
increasing worldwide. Its etiology includes nutritional, genetic, and lifestyle factors. Several mechanisms may link onecarbon metabolism – the associated metabolic pathways of
folate, methionine, and choline – to the onset of NAFLD. In
this review, we attempted to assess how choline, folate, methionine, and betaine affect NAFLD development, mainly
through their role in the secretion of very low-density lipoproteins (VLDL) from the liver. We also reviewed recent articles that have described the relation between microbiota
metabolism and NAFLD progression. Moreover, we describe
the effect of single-nucleotide polymorphisms (SNP) in
genes related to one-carbon metabolism and disease prevalence. We additionally seek SNP identified by genome-wide
associations that may increase the risk of this disease. Even
though the evidence available is not entirely consistent, it
seems that the concentrations of choline, methionine, folate, and betaine may affect the progression of NAFLD. Since
there is no effective therapy for NAFLD, further investigations into the link between nutrition, gut microbiota, genetic factors, and NAFLD are still necessary, with a particular emphasis on methyl donors
One-carbon metabolism and nonalcoholic fatty liver disease: The crosstalk between nutrients, microbiota, and genetics
The prevalence of nonalcoholic fatty liver disease (NAFLD) is
increasing worldwide. Its etiology includes nutritional, genetic, and lifestyle factors. Several mechanisms may link onecarbon metabolism – the associated metabolic pathways of
folate, methionine, and choline – to the onset of NAFLD. In
this review, we attempted to assess how choline, folate, methionine, and betaine affect NAFLD development, mainly
through their role in the secretion of very low-density lipoproteins (VLDL) from the liver. We also reviewed recent articles that have described the relation between microbiota
metabolism and NAFLD progression. Moreover, we describe
the effect of single-nucleotide polymorphisms (SNP) in
genes related to one-carbon metabolism and disease prevalence. We additionally seek SNP identified by genome-wide
associations that may increase the risk of this disease. Even
though the evidence available is not entirely consistent, it
seems that the concentrations of choline, methionine, folate, and betaine may affect the progression of NAFLD. Since
there is no effective therapy for NAFLD, further investigations into the link between nutrition, gut microbiota, genetic factors, and NAFLD are still necessary, with a particular emphasis on methyl donors