Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA

A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide. While unpaired oligomers of 2,4-disubstituted furan amino acids show poor DNA-binding activity, furan (Fn) carboxamides paired with N-methylpyrrole (Py) and N-methylimidazole (Im) rings demonstrate excellent stabilization of duplex DNA as well as discrimination of noncognate sequences, consistent with function as a Py mimic according to the Py/Im polyamide pairing rules

Critical velocity and event horizon in pair-correlated systems with "relativistic" fermionic quasiparticles

The condition for the appearance of event horizon is considered in such pair-correlated systems (superfluids and superconductors) where the fermionic quasiparticles obey the "relativistic" equations. In these systems, the Landau critical velocity of superflow corresponds to the speed of light. In conventional systems, such as s-wave superconductors, the superflow remains stable even above the Landau treshold. We showed that in the "relativistic" systems however the quantum vacuum becomes unstable and the superflow collapses after the "speed of light" is reached, so that horizon cannot appear. Thus an equilibrium dissipationless superfluid flow state and the horizon are incompatible due to quantum effects. This negative result is consistent with the quantum Hawking radiation from the horizon, which would lead to the dissipation of the flow.Comment: RevTex file, 4 pages, 1 Figur

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms. The DNA-binding dependent mechanism occurs by direct binding of GR to glucocorticoid response elements (GREs) at regulatory regions of target genes. The DNA-binding independent mechanism involves binding of GR to transcription factors and coactivators that, in turn, contact DNA. A small molecule that competes with GR for binding to GREs could be expected to affect the DNA-dependent pathway selectively by interfering with the protein-DNA interface. We show that a DNA-binding polyamide that targets the consensus GRE sequence binds the glucocorticoid-induced zipper (GILZ) GRE, inhibits expression of GILZ and several other known GR target genes, and reduces GR occupancy at the GILZ promoter. Genome-wide expression analysis of the effects of this polyamide on a set of glucocorticoid-induced and -repressed genes could help to elucidate the mechanism of GR regulation for these genes

Effects of Magnetic Order on the Upper Critical Field of UPt3_3

I present a Ginzburg-Landau theory for hexagonal oscillations of the upper critical field of UPt$_3$ near $T_c$. The model is based on a $2D$ representation for the superconducting order parameter, $\vec{\eta}=(\eta_1,\eta_2)$, coupled to an in-plane AFM order parameter, $\vec{m}_s$. Hexagonal anisotropy of $H_{c2}$ arises from the weak in-plane anisotropy energy of the AFM state and the coupling of the superconducting order parameter to the staggered field. The model explains the important features of the observed hexagonal anisotropy [N. Keller, {\it et al.}, Phys. Rev. Lett. {\bf 73}, 2364 (1994).] including: (i) the small magnitude, (ii) persistence of the oscillations for $T\rightarrow T_c$, and (iii) the change in sign of the oscillations for $T> T^{*}$ and $T< T^{*}$ (the temperature at the tetracritical point). I also show that there is a low-field crossover (observable only very near $T_c$) below which the oscillations should vanish.Comment: 9 pages in a RevTex (3.0) file plus 2 postscript figures (uuencoded). Submitted to Physical Review B (December 20, 1994)

Singularity of the Vortex Density of States in d-wave Superconductors

In d-wave superconductors, the electronic density of states (DOS) induced by a vortex exhibits 1/|E| divergency at low energies. It is the result of gap nodes in the excitations spectrum outside the vortex core. The heat capacity in two regimes, (T/T_c)^2 >> B/B_{c2} and (T/T_c)^2 << B/B_{c2}, is discussed.Comment: LaTeX file, 8 pages, no figures, submitted to JETP Letter

Quantization of Superflow Circulation and Magnetic Flux with a Tunable Offset

Quantization of superflow-circulation and of magnetic-flux are considered for systems, such as superfluid $^3$He-A and unconventional superconductors, having nonscalar order parameters. The circulation is shown to be the anholonomy in the parallel transport of the order parameter. For multiply-connected samples free of distributed vorticity, circulation and flux are predicted to be quantized, but generically to nonintegral values that are tunably offset from integers. This amounts to a version of Aharonov-Bohm physics. Experimental settings for testing these issues are discussed.Comment: 5 two-column pages, ReVTeX, figure available upon request (to [email protected]

Criticality and Superfluidity in liquid He-4 under Nonequilibrium Conditions

We review a striking array of recent experiments, and their theoretical interpretations, on the superfluid transition in $^4$He in the presence of a heat flux, $Q$. We define and evaluate a new set of critical point exponents. The statics and dynamics of the superfluid-normal interface are discussed, with special attention to the role of gravity. If $Q$ is in the same direction as gravity, a self-organized state can arise, in which the entire sample has a uniform reduced temperature, on either the normal or superfluid side of the transition. Finally, we review recent theory and experiment regarding the heat capacity at constant $Q$. The excitement that surrounds this field arises from the fact that advanced thermometry and the future availability of a microgravity experimental platform aboard the International Space Station will soon open to experimental exploration decades of reduced temperature that were previously inaccessible.Comment: 16 pages, 9 figures, plus harvard.sty style file for references Accepted for publication in Colloquia section of Reviews of Modern Physic

BCS and generalized BCS superconductivity in relativistic quantum field theory. I. formulation

We investigate the BCS and generalized BCS theories in the relativistic quantum field theory. We select the gauge freedom as U(1), and introduce a BCS-type effective attractive interaction. After introducing the Gor'kov formalism and performing the group theoretical consideration of the mean fields, we solve the relativistic Gor'kov equation and obtain the Green's functions in analytical forms. We obtain various types of gap equations.Comment: 31 page

Minimal Cooling of Neutron Stars: A New Paradigm

A new classification of neutron star cooling scenarios, involving either ``minimal'' cooling or ``enhanced'' cooling is proposed. The minimal cooling scenario replaces and extends the so-called standard cooling scenario to include neutrino emission from the Cooper pair breaking and formation process. This emission dominates that due to the modified Urca process for temperatures close to the critical temperature for superfluid pairing. Minimal cooling is distinguished from enhanced cooling by the absence of neutrino emission from any direct Urca process, due either to nucleons or to exotica. Within the minimal cooling scenario, theoretical cooling models can be considered to be a four parameter family involving the equation of state of dense matter, superfluid properties of dense matter, the composition of the neutron star envelope, and the mass of the neutron star. Consequences of minimal cooling are explored through extensive variations of these parameters. Results are compared with the inferred properties of thermally-emitting neutron stars in order to ascertain if enhanced cooling occurs in any of them. All stars for which thermal emissions have been clearly detected are at least marginally consistent with the lack of enhanced cooling. The two pulsars PSR 0833-45 (Vela) and PSR 1706-44 would require enhanced cooling in case their ages and/or temperatures are on the lower side of their estimated values whereas the four stars PSR 0656+14, PSR 1055-52, Geminga, and RX J0720.4-3125 may require some source of internal heating in case their age and/or luminosity are on the upper side of their estimated values. The new upper limits on the thermal luminosity of PSR J0205+6449 and RX J0007.0+7302 are indicative of the occurrence of some enhanced neutrino emission beyond the minimal scenario.Comment: Version to appear in ApJ Supplements. Minor modifications in text and discussion of updated data with new figure

Microwave Assisted Synthesis of Py-Im Polyamides

Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5′-WGWWCW-3′ (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several additional coupling steps