Iron III isomaltose induced hypersensitivity reaction

Iron isomaltose is considered as safe form of iron with no test dose recommended. Here, we are describing the case of a patient who experienced allergic reaction with this formulation of iron. A 35-year-old South Asian woman experienced allergic reaction, she had mild wheeze on examination of chest. She was given intranasal oxygen at 2 L/min. She was given intravenous acetaminophen 1 g for pain relief, 45.4 mg intravenous chlorphenaramine and intravenous 100 mg hydrocortisone. Within half an hour, all her symptoms improved and her hypoxia resolved. Her chest wheezing also disappeared. Iron isomaltose, although relatively safe, can cause allergic reaction. Intravenous iron can cause allergic reaction therefore it should be administered at the facility where trained staff is present so that necessary treatment can be given in case of hypersensitivity reaction

Cholestyramine, a cost-effective yet efficacious anti-dote in digoxin toxicity

Digoxin is a cardiac glycoside obtained from digitalis lanata, is a positive inotropic and negative chronotropic agent. Digoxin works by blocking Na-K ATPase pump resulting in raised intracellular sodium which in turn raise intracellular calcium in the myocytes resulting in increase in inotropic effect [1, 2]. Digoxin causes several adverse effects in overdose leading to both bradyarrhythmias and tachyarrhythmias. The approved antidote, digoxin-specific antibody fragments (DIGIFAB), is costly yet effective option for managing digoxin toxicity [3] we describe the cases in which levels of digoxin fell to acceptable therapeutic levels with the use of Cholestyramine

Evaluation of MONOFER-induced hypersensitive reactions: A retrospective cohort study

Iron deficiency is the most common cause of anaemia. Over the years, various IV preparations of iron have been developed, including Monofer® (Iron isomaltoside 1000), that showed a remarkable reduction in the occurance of hypersensitivity reactions. The main aim of the study was to evaluate the severity and extent to which hypersensitivity reactions occur after the administration of IV iron isomaltoside 1000 in an Asian population. Multistage sampling was adopted for this study. The overall sample size was 864. The mean age of the participants was 55.29 ±18.44 years. The results depicted that 63 (7.29%) of the entire participants faced hypersensitivity reactions after IV administration. A total of 43 (68.25%) participants who experienced hypersensitivity reactions showed clinical symptoms within one hour, 11(17.46%) showed reaction in 1-3 hours and 9 (14.29%) showed in \u3e 3 Hours. The majority of the studied population showed significant improvement only after the administration of Pheniramine maleate, while only a few of them received Hydrocortisone