3 research outputs found
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Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
A solvent-free approach to intensification of chemical processes is reported. This concept, in which reactions are carried out solvent-free, without the need for further downstream processing, was highlighted first with a full reduction of ethyl nicotinate to ethylpiperidine-3-carboxylate under continuous flow conditions. Using a small footprint reactor, a throughput of 26.4 g h–1 was achieved. Similarly, this approach was used for the telescoped two-step synthesis of 2-propyl phenol (productivity 120 g h–1) and 2-propyl cyclohexanone (productivity 30 g h–1), starting from the commercially available allyl phenol ether via Claisen rearrangement and subsequent reduction.We would like to thank Pfizer Worldwide Research & Development (CB), the EPSRC (RJM, SVL, Grant Codes EP/K009494/1, EP/M004120/1 and EP/K039520/1) and the Woolf Fisher Trust (DEF) for financial support.This is the final version of the article. It first appeared from the American Chemical Society via https://doi.org/10.1021/acssuschemeng.6b0028
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Research data supporting “A Parallel Column Supercritical Fluid Chromatography System for Continuous Purification”
The data is twofold. First is the individual chromatograms of each experiment highlighted in the publication. Second is the NMR spectra of the fractions separated during the experiments.EPSRC [EP/K009494/1, EP/ M004120/1
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Research data supporting: 'Solvent-free Continuous Operations using Small Footprint Reactors: a Key Approach for Process Intensification'.
1H and 13C NMR data for 2 allyl phenol, produced via the Claisen rearrangement of allyl phenyl ether. Data collected on 25/01/16 1H and 13C NMR data for 2 propyl phenol, produced via the partial reduction of 2 allyl phenol. Data collected on 25/01/16 1H and 13C NMR data for 2-propyl cyclohexanone, produced via the reduction of 2 allyl phenol. Data collected on 25/01/16.This work was supported by the EPSRC [grant numbers EP/K009494/1, EP/M004120/1 and EP/K039520/1], the Pfizer Worldwide Research & the Development, Woolf Fisher Trust