18 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
O esporte na qualidade de vida de indivĂduos com lesĂŁo da medula espinhal: sĂ©rie de casos
INTRODUĂĂO: A lesĂŁo da medula espinhal Ă© um trauma de impacto fĂsico e social ao indivĂduo, que acarreta profundas modificaçÔes na vida de seus portadores pela paraplegia ou tetraplegia resultante. O objetivo deste estudo foi avaliar a percepção da qualidade de vida de indivĂduos com lesĂŁo da medula espinhal, antes e apĂłs um perĂodo de treinamento esportivo. MĂTODOS: Participaram do estudo 16 indivĂduos paraplĂ©gicos por lesĂŁo da medula espinhal, que realizaram treinamento esportivo da modalidade basquetebol em cadeira de rodas, com duração de duas horas por dia e frequĂȘncia de duas vezes por semana, por um perĂodo de um ano. Para avaliação da qualidade de vida PRĂ e PĂS o perĂodo de treinamento, foi utilizado o questionĂĄrio SF-36. RESULTADOS: Houve melhora geral na qualidade de vida (p = 0,006) dos participantes quando considerados os escores de todos os domĂnios do questionĂĄrio somados PRĂ (605,7) e PĂS (651,9) treinamento. Ainda, analisando de forma especĂfica, foi observada melhora com significĂąncia estatĂstica na capacidade funcional (p = 0,004), estado geral de saĂșde (p = 0,001) e aspectos emocionais (p = 0,02). CONCLUSĂO: O treinamento esportivo mostrou-se benĂ©fico, promove melhora na qualidade de vida de pessoas com lesĂŁo da medula espinhal que necessitam de cadeira de rodas para mobilidade e representa novos objetivos e desafios na continuidade no processo de reabilitação