A Historical Evaluation of Financial Accelerator Effects in Japan's Economy

In this paper, we carry out a historical evaluation of the financial accelerator effects, which were mainly generated by the changes in asset prices, operating on Japan's economy since the 1980s. For this purpose, we estimate a Japanese financial accelerator model, which is a modified version of Bernanke, Gertler and Gilchrist [1999]'s model, and identify the historical exogenous shocks affecting the evolution of firms' net worth. As a result, we confirm that the estimated parameter on the corporate balance sheet channel is statistically significant. We also find that the identified net worth shocks, which change the amount of firms' debt holdings relative to their total values, produced a large and persistent impact on Japan's output and prices. This result strongly suggests that the negative financial accelerator effects were indispensable to explain the mechanism behind Japan's long stagnation during the 1990s and early 2000s, as well as indicating that the deflation of general prices since the late 1990s has been at least partly attributed to the same cause.

The 'disembodied voice' in fin-de-siècle British literature : its genealogy and significances

A particular kind of voice recurs in fin-de-siècle British literature. It is a voice without a human body, a voice whose source is either invisible or non-human. This study explores the historical factors underlying the literary representation of such a voice. Chapter 1 examines Arthur Symons' phrase, 'the disembodied voice of a human soul,' and sets up the context for the subsequent discussion by teasing out the four major implications of the fin-de-siècle disembodied voice: the socio-political, the aesthetico-linguistic, the techno-scientific, and the sexual-somatic. Chapter 2 first outlines the modern origin of the disembodied voice in the Gothic-Romantic culture of the late eighteenth century, where the frequent description of the disembodied voice is linked to the rise of the nostalgia for premodernity; the chapter then analyzes the disembodied voice in Joseph Conrad's Heart of Darkness both in terms of Gothic culture and of the fin-de-siècle situation. The Romantic aesthetico-linguistic prioritization of the aural-oral, which we call 'melocentricism,' the fin-de-siècle consumerism and colonialism, and the then influential scientific concept of ether receive scrutiny. Chapter 3 addresses Oscar Wilde's Salome. Apart from the factors that this play shares with Conrad's novella, the disembodied voice in Salome secretly expresses a longing for the homosexual-cum-communal. Chapter 4 explores the fin-de-siècle imperial and homosexual implications, and the 'melocentric' pre-history, of the phonographic voice in Bram Stoker's Dracula. Chapter 5 teases out the hidden political dimension of the technological voice, phonographic and wireless, in Kipling's Kim and '"Wireless".' Chapter 6 compares the fin-de-siècle voice with an instance of the early twentieth-century, the wireless voice in D. H. Lawrence's Ladv Chatterley's Lover, a voice now involved in the global network of broadcasting. It is concluded that the disembodied voice is inseparable from important aspects of fin-de-siècle British culture as well as the question of modernity

The Specific Heat of Copper Alloys Containing Small Amounts of Iron

The specific heat of copper alloys containing small amounts of iron (0.3 to 3.5 at. % of iron) was measured under various heat treatment conditions at liquid helium temperatures. The excess specific heat of copper-iron alloys in solid solution was observed and it would be due to a magnetic origin. It is tried to explain the specific heat by the Marshall-Klein theory based on s-d interactions and the Ising model. The specific heat of copper alloys containing γ-iron precipitates involves a temperature independent contribution from the superparamagnetic character of γ-iron precipitates

An integrated analysis of hyponatremia in cancer patients receiving platinum-based or nonplatinum-based chemotherapy in clinical trials (JCOG1405-A)

Background: Hyponatremia is a common electrolyte abnormality in cancer patients who receive chemotherapy. Among anticancer agents, platinum-based agents are reported to cause chemotherapy-induced hyponatremia. However, the actual incidence and risk factors remain unknown. Results: The reports of 29 trials were analyzed. The incidence of grade 3/4 hyponatremia was 11.9% in patients treated with platinum-based chemotherapy and 3.8% in those treated with nonplatinum-based regimens (P < 0.01). Univariable analysis revealed a high incidence of hyponatremia in patients receiving cisplatin, three-drug combination regimen, two-drug combination regimen with amrubicin or irinotecan, or high-dose cisplatin (weekly equivalent cisplatin dose ≥20 mg/m²), and in patients with small-cell lung cancer. Conclusion: This is the first report of the actual incidence and the potential risk factors of chemotherapy-induced hyponatremia. Careful monitoring of serum sodium level is needed when platinum-based chemotherapy is administered. Methods: This study included all clinical trials of systemic chemotherapies for solid cancers that were conducted by the Japan Clinical Oncology Group (JCOG) after January 2000 and of which the patient enrolment was completed by January 2014. The latest reports of each trial were used for analysis. The incidence of chemotherapy-induced grade 3/4 hyponatremia and the potential risk factors were investigated with univariable analysis

Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16

<p>Abstract</p> <p>Background</p> <p>Herpes simplex virus type 1 (HSV-1) has a complicated life-cycle, and its genome encodes many components that can modify the cellular environment to facilitate efficient viral replication. The protein UL14 is likely involved in viral maturation and egress (Cunningham C. et al), and it facilitates the nuclear translocation of viral capsids and the tegument protein VP16 during the immediate-early phase of infection (Yamauchi Y. et al, 2008). UL14 of herpes simplex virus type 2 exhibits multiple functions (Yamauchi Y. et al, 2001, 2002, 2003).</p> <p>Methods</p> <p>To better understand the function(s) of UL14, we generated VP16-GFP-incorporated UL14-mutant viruses with either single (K51M) or triple (R60A, R64A, E68D) amino acid substitutions in the heat shock protein (HSP)-like sequence of UL14. We observed the morphology of cells infected with UL14-null virus and amino acid-substituted UL14-mutant viruses at different time points after infection.</p> <p>Results</p> <p>UL14(3P)-VP16GFP and UL14D-VP16GFP (UL14-null) viruses caused similar defects with respect to growth kinetics, compartmentalization of tegument proteins, and cellular morphology in the late phase. Both the UL14D-VP16GFP and UL14(3P)-VP16GFP viruses led to the formation of an aggresome that incorporated some tegument proteins but did not include nuclear-egressed viral capsids.</p> <p>Conclusions</p> <p>Our findings suggest that a cluster of charged residues within the HSP-like sequence of UL14 is important for the molecular chaperone-like functions of UL14, and this activity is required for the acquisition of functionality of VP16 and UL46. In addition, UL14 likely contributes to maintaining cellular homeostasis following infection, including cytoskeletal organization. However, direct interactions between UL14 and VP16, UL46, or other cellular or viral proteins remain unclear.</p

A Historical Evaluation of Financial Accelerator Effects in Japan's Economy

In this paper, we carry out a historical evaluation of the financial accelerator effects, which were mainly generated by the changes in asset prices, operating on Japan's economy since the 1980s. For this purpose, we estimate a Japanese financial accelerator model, which is a modified version of Bernanke, Gertler and Gilchrist [1999]'s model, and identify the historical exogenous shocks affecting the evolution of firms' net worth. As a result, we confirm that the estimated parameter on the corporate balance sheet channel is statistically significant. We also find that the identified net worth shocks, which change the amount of firms' debt holdings relative to their total values, produced a large and persistent impact on Japan's output and prices. This result strongly suggests that the negative financial accelerator effects were indispensable to explain the mechanism behind Japan's long stagnation during the 1990s and early 2000s, as well as indicating that the deflation of general prices since the late 1990s has been at least partly attributed to the same cause