Nosocomial infections: surgical site infection in UCH Ibadan, Nigeria

Surgical wound infection is a good index of Hospital Acquired Infection (HAI). The programme of Surveillance of HAI in University College Hospital (UCH), Ibadan, Nigeria, started in January 1976. Thelast audit of the programme reported the situation between January 1989 and December 1991, whence the prevalence of HAI was found to be 4.9%. The programme of Surveillance of HAI from year 1995 to 2004 was audited. All wound swabs/biopsies sent for microscopy, culture and sensitivity were analysed. Previous incidence of nosocomial Infection in the environment was obtained from literature. The prevalence of HAI was 3.0%, Surgical Site Infection was the second most prevalent HAI. Surgical Site Infection was responsible for 27.9% of the nosocomial infections recorded. The ratio of Gram Positive to Gram Negative organisms was 1:2.3. Bacterial agents of Surgical Site Infection were Staphylococcus aureus 29.0%, Klebsiella spp 25.3%, Pseudomonas spp 21.7%, Proteus spp 11.7% E. coli 11.3%, Streptococcus pyogenes 0.6% and Enterococcus faecalis 0.3%.A decrease from 4.9% to 3.0% in prevalence rate of HAI was observed, compared with the earlier review as a result of refresher courses in Controls of Hospital Infections. To reduce the menace of Surgical SiteInfections, prophylactic antibiotic with short courses of quinolone is advocated as well as adequate wound surveillance and Hospital Workers’ medical care

In-vitro Antimicrobial Efficacy of Carex Powerful Antiseptic Liquid

The Paterson Zochonis Industries in Lagos, Nigeria recently produced Carex Powerful Antiseptic Liquid, which was investigated for antimicrobial activities against common human skin pathogenic bacteria, yeasts and a dermatophyte including Staphylococcus aureus, Pseudomonas aeruginosa, Malassezia furfur, Candida albicans and Trichophyton mentagrophytes. The microbes were challenged in-vitro with 0.7% and undiluted Carex antiseptic liquids for a period between 30 seconds and 120 seconds and the microbial cell reduction rates were determined at every 30 seconds contact by time kill test. Both diluted and undiluted Carex antiseptic liquids produced 100% reduction in all the microbial cells tested except Pseudomonas aeruginosa in which 62% and 100% cell reductions were observed for diluted and undiluted Carex antiseptic liquids respectively within 30 seconds of contact time. It is concluded that Carex Powerful Antiseptic liquid made by the PZ Industries has antimicrobial activities but its non-toxicity to human skin should be proven by subjecting the preparation to clinical trial. Keywords: Carex Antiseptic Liquid, Time Kill Test. Nigerian Journal of Health and Biomedical Sciences Vol. 7 (2) 2008: pp. 44-5