3 research outputs found
Highly Enantioselective Synthesis of 2,3-Dihydroquinazolinones through Intramolecular Amidation of Imines
Enantioselective synthesis of 2,3-dihydroquinazolinones (DHQZs) was accomplished using readily available Sc(III)-<i>inda</i>-pybox as the catalyst. This is the first report on the metal catalyzed asymmetric intramolecular amidation of imines to synthesize DHQZs
Highly Enantioselective Synthesis of 2,3-Dihydroquinazolinones through Intramolecular Amidation of Imines
Enantioselective synthesis of 2,3-dihydroquinazolinones (DHQZs) was accomplished using readily available Sc(III)-<i>inda</i>-pybox as the catalyst. This is the first report on the metal catalyzed asymmetric intramolecular amidation of imines to synthesize DHQZs
Palladium Catalyzed Asymmetric Allylation of 3‑OBoc-Oxindoles: An Efficient Synthesis of 3‑Allyl-3-hydroxyoxindoles
3-Allyl-3-hydroxyoxindoles
were synthesized in very good enantio-
(up to 97% ee) and diastereoselectivities (dr up to 7.6:1) with contiguous
quaternary and tertiary stereogenic centers by employing tartrate
derived bi(oxazoline) in Pd-catalyzed allylation of 3-OBoc-oxindole.
Synthetic utility of 3-allyl-3-hydroxyoxindole was demonstrated by
synthesizing a highly substituted spiro(oxindole-3,2′-tetrahydrofuran)
derivative in good yield and stereoselectivity