Exploring reionization and high-z galaxy observables with recent multiredshift MWA upper limits on the 21-cm signal

We use the latest multiredshift (z = 6.5-8.7) upper limits on the 21-cm signal from the Murchison Widefield Array (MWA) to explore astrophysical models which are inconsistent with the data. We explore these limits in the context of reionization astrophysics by using 21CMMC to connect the disfavoured regions of parameter space to existing observational constraints on reionization such as high-z galaxy ultraviolet (UV) luminosity functions, the background UV photoionization rate, the intergalactic medium (IGM) neutral fraction, the electron scattering optical depth and the soft-band X-ray emissivity. We find the vast majority of disfavoured models to already be inconsistent with existing observational constraints. These can be broadly classified into two types of models: (i) 'cold' reionization and (ii) pure matter density fluctuations in a cold, neutral IGM (i.e. no reionization). Interestingly, a small subsample of models inconsistent with the MWA is consistent with the aforementioned constraints (excluding the X-ray emissivity). This implies that the current MWA limits are already providing unique information to disfavour models of reionization, albeit extremely weakly. We also provide the first limits on the soft-band X-ray emissivity from galaxies at high redshifts, finding 1σ lower limits of X, 0.5-2 keV 1034.5 erg s-1 Mpc-3. Finally, we recover 95 per cent disfavoured limits on the IGM spin temperature of TS 1.3, 1.4, 1.5, 1.8, 2.1, and 2.4 K at z = 6.5, 6.8, 7.1, 7.8, 8.2, and 8.7. With this, we infer the IGM must have undergone, at the very least, a small amount of X-ray heating. Note, the limits on X, 0.5-2 keV and TS are conditional on the IGM neutral fraction

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Tissue factor pathway inhibitor antigen and activity in 96 patients receiving heparin for cardiopulmonary bypass

Objective: To identify patients with poor tissue factor pathway inhibitor (TFPI) response to heparin and observe any association with increased risk of excessive coagulation activation, morbidity, or mortality

Flammability and the heat of combustion of natural fuels: a review

Heat of combustion (HoC) is a key characteristic of fuels when analyzing and modeling wildfire scenarios. Despite significant differences in the structure of fuels from different environments, HoC is frequently considered a constant. This article briefly reviews methods used to describe natural fuels and the various different definitions of HoC. We also summarize measured values of HoC and elemental analyses of 238 plant genera reported in 28 papers since 1973. A statistical analysis of these data provided mean values and standard deviations of HoC for fuels according to six broad plant functional groups. Permutational Multivariate Analysis of Variance (PERMANOVA) demonstrated significant differences in the HoC with ground fuels and softwoods having particularly high values. Net heat of combustion was calculated for four fuel groups and the tabulated data may help to improve wildfire modeling and highlights fuels where further measurements of HoC are required

The prevalence of galaxy overdensities around UV-luminous Lyman α emitters in the Epoch of Reionization

Before the end of the Epoch of Reionization, the Hydrogen in the Universe was predominantly neutral. This leads to a strong attenuation of Ly α lines of z ≳ 6 galaxies in the intergalactic medium. Nevertheless, Ly α has been detected up to very high redshifts (z ∼ 9) for several especially UV luminous galaxies. Here, we test to what extent the galaxy’s local environment might impact the Ly α transmission of such sources. We present an analysis of dedicated Hubble Space Telescope (HST) imaging in the CANDELS/EGS field to search for fainter neighbours around three of the most UV luminous and most distant spectroscopically confirmed Ly α emitters: EGS-zs8-1, EGS-zs8-2, and EGSY-z8p7 at zspec = 7.73, 7.48, and 8.68, respectively. We combine the multiwavelength HST imaging with Spitzer data to reliably select z ∼ 7–9 galaxies around the central, UV-luminous sources. In all cases, we find a clear enhancement of neighbouring galaxies compared to the expected number in a blank field (by a factor ∼3–9×). Our analysis thus reveals ubiquitous overdensities around luminous Ly α emitting sources in the heart of the cosmic reionization epoch. We show that our results are in excellent agreement with expectations from the DRAGONS simulation, confirming the theoretical prediction that the first ionized bubbles preferentially formed in overdense regions. While three UV luminous galaxies already have spectroscopic redshifts, the majority of the remaining fainter, surrounding sources are yet to be confirmed via spectroscopy. JWST follow-up observations of the neighbouring galaxies identified here will thus be needed to confirm their physical association and to map out the ionized regions produced by these sources

The prevalence of galaxy overdensities around UV-luminous Lyman α emitters in the Epoch of Reionization

Before the end of the Epoch of Reionization, the Hydrogen in the Universe was predominantly neutral. This leads to a strong attenuation of Ly α lines of z ≳ 6 galaxies in the intergalactic medium. Nevertheless, Ly α has been detected up to very high redshifts (z ∼ 9) for several especially UV luminous galaxies. Here, we test to what extent the galaxy’s local environment might impact the Ly α transmission of such sources. We present an analysis of dedicated Hubble Space Telescope (HST) imaging in the CANDELS/EGS field to search for fainter neighbours around three of the most UV luminous and most distant spectroscopically confirmed Ly α emitters: EGS-zs8-1, EGS-zs8-2, and EGSY-z8p7 at zspec = 7.73, 7.48, and 8.68, respectively. We combine the multiwavelength HST imaging with Spitzer data to reliably select z ∼ 7–9 galaxies around the central, UV-luminous sources. In all cases, we find a clear enhancement of neighbouring galaxies compared to the expected number in a blank field (by a factor ∼3–9×). Our analysis thus reveals ubiquitous overdensities around luminous Ly α emitting sources in the heart of the cosmic reionization epoch. We show that our results are in excellent agreement with expectations from the DRAGONS simulation, confirming the theoretical prediction that the first ionized bubbles preferentially formed in overdense regions. While three UV luminous galaxies already have spectroscopic redshifts, the majority of the remaining fainter, surrounding sources are yet to be confirmed via spectroscopy. JWST follow-up observations of the neighbouring galaxies identified here will thus be needed to confirm their physical association and to map out the ionized regions produced by these sources

The prevalence of galaxy overdensities around UV-luminous Lyman α emitters in the Epoch of Reionization

Before the end of the Epoch of Reionization, the Hydrogen in the Universe was predominantly neutral. This leads to a strong attenuation of Ly α lines of z ≳ 6 galaxies in the intergalactic medium. Nevertheless, Ly α has been detected up to very high redshifts (z ∼9) for several especially UV luminous galaxies. Here, we test to what extent the galaxy's local environment might impact the Ly α transmission of such sources. We present an analysis of dedicated Hubble Space Telescope (HST) imaging in the CANDELS/EGS field to search for fainter neighbours around three of the most UV luminous and most distant spectroscopically confirmed Ly α emitters: EGS-zs8-1, EGS-zs8-2, and EGSY-z8p7 at zspec = 7.73, 7.48, and 8.68, respectively. We combine the multiwavelength HST imaging with Spitzer data to reliably select z ∼7-9 galaxies around the central, UV-luminous sources. In all cases, we find a clear enhancement of neighbouring galaxies compared to the expected number in a blank field (by a factor ∼3-9×). Our analysis thus reveals ubiquitous overdensities around luminous Ly α emitting sources in the heart of the cosmic reionization epoch. We show that our results are in excellent agreement with expectations from the Dragons simulation, confirming the theoretical prediction that the first ionized bubbles preferentially formed in overdense regions. While three UV luminous galaxies already have spectroscopic redshifts, the majority of the remaining fainter, surrounding sources are yet to be confirmed via spectroscopy. JWST follow-up observations of the neighbouring galaxies identified here will thus be needed to confirm their physical association and to map out the ionized regions produced by these sources. © 2022 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society.Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]