Selçukluların Nîşâbur’a Girişi ve Gazneli Bürokrasisinin Tepkisi

Türk, İslam ve dünya tarihinde önemli bir yere sahip olan Selçuklular, 10. yüzyılın sonlarından itibaren Doğu İslam dünyası içinde meydana gelen siyasi olaylarda rol oynamaya başlamışlardır. Bu dönemde Sâmânîler, Karahanlılar ve Gazneliler arasındaki siyasi ortamda Selçuklular, çevresindeki bu devletler tarafından kimi zaman destek için başvurulan kimi zaman da tehdit olarak algılanan bir güç olarak karşımıza çıkmışlardır. Selçukluların 1035 yılında Ceyhun nehrini geçerek Horasan bölgesine girmeleri sadece kendi geleceklerini değil bölgenin de siyasi geleceğini derinden etkilemiştir. 1035 tarihinden 1040’taki Dandanakan savaşına kadar geçen süreçte Horasan’da Gazneliler ile Selçuklular arasında yaşanan mücadeleler Büyük Selçuklu Devletinin kurulmasıyla sonuçlanmıştır. Selçukluların 1038 yılındaki Serahs galibiyeti Gaznelilerin bölgedeki askeri gücüne büyük bir darbe vururken Selçukluların da Horasan’ın merkezi olan Nîşâbur şehrini ele geçirmelerine sebep olmuştur. Bu olay Selçukluların devlet sahibi olma düşüncelerini güçlendirmekle kalmamış bu yönde karar almalarına ve hareket etmelerine de olanak sağlamıştır. Bu çalışmada, Selçukluların Horasan’da devletleşme süreçlerinde önemli bir yer işgal eden Nîşâbur’un Selçuklu Türkmenleri tarafından ele geçirilmesi olayı ve buna karşı Nîşâbur’daki dolayısıyla Horasan’daki Gazneli bürokrasisinin bu olaya tepkisi ele alınacaktı

Brucella Endocarditis Caused By Brucella Melitensis

Brucellosis is a zoonotic disease endemically seen in Turkey, which occurs with various clinical findings. It can lead to complications affecting many systems. Endocarditis is an infrequent, but serious complication of brucellosis.The aim of this case presentation is to remind that endocarditis can be a complication of brucellosis and if is undiagnosed or misdiagnosed, progresses fatal in a high rate

A machine learning approach for microRNA precursor prediction in retro-transcribing virus genomes

PubMed: 28187417Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially classification. In order to achieve successful classification, many parameters need to be considered such as data quality, choice of classifier settings, and feature selection. For the latter one, we developed a distributed genetic algorithm on HTCondor to perform feature selection. Moreover, we employed two widely used classification algorithms libSVM and random forest with different settings to analyze the influence on the overall classification performance. In this study we analyzed 5 human retro virus genomes; Human endogenous retrovirus K113, Hepatitis B virus (strain ayw), Human T lymphotropic virus 1, Human T lymphotropic virus 2, Human immunodeficiency virus 2, and Human immunodeficiency virus 1. We then predicted pre-miRNAs by using the information from known virus and human pre-miRNAs. Our results indicate that these viruses produce novel unknown miRNA precursors which warrant further experimental validation

A Machine Learning Approach for MicroRNA Precursor Prediction in Retro-transcribing Virus Genomes

Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially classification. In order to achieve successful classification, many parameters need to be considered such as data quality, choice of classifier settings, and feature selection. For the latter one, we developed a distributed genetic algorithm on HTCondor to perform feature selection. Moreover, we employed two widely used classification algorithms libSVM and random forest with different settings to analyze the influence on the overall classification performance. In this study we analyzed 5 human retro virus genomes; Human endogenous retrovirus K113, Hepatitis B virus (strain ayw), Human T lymphotropic virus 1, Human T lymphotropic virus 2, Human immunodeficiency virus 2, and Human immunodeficiency virus 1. We then predicted pre-miRNAs by using the information from known virus and human pre-miRNAs. Our results indicate that these viruses produce novel unknown miRNA precursors which warrant further experimental validation

Pericardial tube graft in superior vena cava syndrome: A case report

Surgical treatment of superior vena cava syndrome is one of the venous surgeries with acceptable outcomes. In this case report, we present a 46-year-old male superior vena cava syndrome case with signs and symptoms of venous hypertension and stasis of the upper extremity and face with a pericardial tube graft

Surgical treatment of mobile right atrial thrombus and pulmonary embolism due to protein C deficiency associated with patent foramen ovale

We present a case of a 36-year-old woman suffering from mobile right atrial thrombus and pulmonary embolism associated with cardiogenic shock. Two-dimensional echocardiography demonstrated a mass in the right atrium prolapsing through the tricuspid valve into the right ventricle during diastole, and leading to partial inflow obstruction. Computed tomography revealed a large mass into the left and right main pulmonary artery leading to obstruction. The laboratory findings of the patients revealed protein C deficiency. An emergency operation was performed and the thrombus in the right atrium and both pulmonary arteries were successfully extracted with using cardiopulmonary bypass. Previously unsuspected a large patent foramen ovale was closed primarily. This exemplary case highlights the benefit of surgical intervention rather than more conservative approaches such as anticoagulation and/or thrombolysis

Attitude of Term II and III Students in Canakkale Onsekiz Mart University School of Medicine Towards Problem Based Learning

Introduction: Problem based learning (PBL) presents complicated real life problems and provides students to use analysing and synthesis abilities while reaching a solution. Students decide on solution pathways and produce concept maps on their own. Problem based learning represents experience-based learning which requires active participation for characterization and solution of the problem. In this study we aimed to evaluate the attitude of medical students to PBL sessions.Methods: In this descriptive designed study, attitude scale towards PBL applied to the Canakkale Onsekiz Mart University School of Medicine term II and III students just after PBL sessions. Results: One hundred twenty five students agreed to participate the study. Reliability co-efficient (co-efficient alfa) of PBL attitude scale (test with 38 clauses) was 0.777. Group work sub-group mean score of term III students was significantly higher than term II students (p=0.050). Lesson subject sub-group mean score was significantly higher in term II students (p=0.036). There were no significant difference between other sup-groups (p>0.05). Conclusion: Students were found to be positive attitude to PBL sessions. Term III students adopted more than term II students. Experiencing more PBL sessions can be important for adopting group work. It would be a mistake to talk about positive attitude towards PBL because of the limited number of PBL sessions in this school of medicine

Linezolid Alone and in Combination with Rifampicin Prevents Experimental Vascular Graft Infection Due to Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Background: In this report we describe the in vivo antibacterial activity of linezolid in an experimental graft infection model in rats and compare it with teicoplanin. The objective of this study was also to determine the effects of the interaction of linezolid when it was combined with rifampicin and test this effect against strains of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Materials and methods: Graft infections were established in the subcutaneous tissue of 130 Wistar rats by implantation of Dacron grafts followed by a topical inoculation with 2 × 107 CFU of clinical isolates of MRSA and MRSE. The study included a control group and six groups for each of the staphylococcal strains: an inoculated group that did not receive any antibiotic prophylaxis, two inoculated groups that received intraperitoneal prophylaxis with teicoplanin or linezolid alone, an inoculated group that received rifampicin-soaked grafts, and two inoculated groups that received a combination prophylaxis consisting of intraperitoneal teicoplanin or linezolid and rifampicin-soaked grafts. Results: There was a reduction in the quantitative bacterial graft cultures in all prophylaxis groups when compared with inoculated control groups. There was not a statistically significant difference between linezolid and teicoplanin prophylaxis groups. The best results were obtained by a combination of rifampicin-soaked grafts with linezolid or teicoplanin. Conclusions: We found no evidence to suggest that linezolid differs from teicoplanin regarding effectiveness in the prevention of prosthetic vascular graft infection. Linezolid plus rifampicin and teicoplanin plus rifampicin are demonstrated to be valuable prophylactic regimens. © 2007 Elsevier Inc. All rights reserved