The Impact of Pupillary Dilation on Intraocular Pressure and Anterior Segment Morphology in Subjects with and without Pseudoexfoliation

Purpose: To investigate the change in pre- and post-dilation anterior segment parameters and intraocular pressure (IOP) of patients with and without pseudoexfoliation, after topical application of phenylephrine HCl 10% and tropicamide 1%

Descemet-stripping automated endothelial keratoplasty in eyes with toxic anterior segment syndrome after cataract surgery

Purpose To report the results of Descemet-stripping automated endothelial keratoplasty (DSAEK) in eyes with toxic anterior segment syndrome (TASS) after cataract surgery. Setting Department of Ophthalmology, Istanbul University Cerrahpaşa Medical Faculty, Istanbul, Turkey. Methods In this prospective study of consecutive patients who had DSAEK for corneal failure due to TASS, the main outcome measures were corneal clarity, mean spherical equivalent (SE) refraction, preoperative and postoperative visual acuities, central corneal thickness, and endothelial cell count (ECC). Results The mean follow-up in the 10 eyes (10 patients) was 17.1 months ± 2.4 (SD). There were no graft dislocations postoperatively, and no graft required repositioning. All grafts were clear at 12months. Two eyes had initial graft rejection that resolved with treatment. All eyes had improved postoperative corrected distance visual acuity, with 7 eyes (70%) attaining 0.5 or better. The mean SE refraction in measurable cases (5 eyes) was 1.2 ± 0.6 preoperatively and 0.9 ± 1.0 postoperatively (P= .141). The decrease in mean pachymetry from preoperatively (691 ± 15 μm) to 12 months postoperatively (614 ± 23 μm) was statistically significant (P=.005). The mean ECC was 2740 ± 236 cells/mm2preoperatively, 1690 ± 209 cells/mm2at 6 months, and 1683 ± 206 cells/mm2at 12 months. The decrease between preoperatively and 6 and 12 months (P= .05) and between 6 months and 12 months (P= .008) was statistically significant. Conclusion Descemet-stripping automated endothelial keratoplasty was safe and effective in eyes with TASS-associated corneal edema, yielding encouraging surgical and visual outcomes

Novel Method to Avoid the Open-Sky Condition in Penetrating Keratoplasty: Covered Cornea Technique

Purpose: The aim of this study was to present a novel technique to avoid the open-sky condition in pediatric and adult penetrating keratoplasty (PK)

Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty

AIM: To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP)

Ambulatory blood pressure monitoring in living kidney donors: What changes in 10 years?

In renal transplantation, living donations have more significant benefits compared to cadaveric donations. However, a probable increase in blood pressure following donation should also be kept in mind. In this study, we investigated the long-term changes in blood pressure in living kidney donors using ambulatory blood pressure monitoring and we explored the e-GFR and albuminuria/proteinuria measurements at 3 time points. Twenty-eight living kidney donors and 39 healthy individuals were evaluated and compared at the baseline and later at the 10th year. At the 10th year, creatinine levels were higher and eGFR levels were lower in the donors, whereas the systolic and diastolic measurements of the donors and controls and the prevalence of non-dipping in the donors and controls were similar. Our study may be underpowered due to its small population size. However, our results at the 10th year follow-up indicated that the risk of hypertension might not seem to have increased in the well-selected donors. In addition, the majority of our donors had preserved their GFR values. Therefore, we can suggest that living kidney donation appears to be safe in well-selected patients over a 10-year time frame

Histologic Findings of Corneal Buttons in Decompensated Corneas With Toxic Anterior Segment Syndrome After Cataract Surgery.

Purpose:To report the histologic findings of penetrating keratoplasty buttons in decompensated corneas with toxic anterior segment syndrome (TASS) after a cataract surgery is performed.Methods:We evaluated the histologic findings of 16 corneal buttons of 16 patients who exhibited decompensation findings because of TASS by means of light microscopy. The patients were classified into 3 groups: The first group consisted of 5 corneal buttons with mild symptoms in which the central corneal thicknesses (CCTs) were 650 m, and the visual acuities (VAs) were 0.1. The second group consisted of 7 corneal buttons that exhibited moderate symptoms in which the CCTs were between 650 and 750 m and the VAs were between 0.1 and 0.03. The third group consisted of 4 corneal buttons that had severe symptoms in which the CCTs were 750 m and the VAs were 0.03.Results:Light microscopy showed endothelial cell loss, vacuolated and thinned epithelial cell layers, disturbed collagen bonds, and Descemet membrane invaginations in patients in group I. Group II corneal buttons exhibited inflammatory cells (lymphocytes) and extended intercellular space between the epithelial cells, wrinkled Bowman membrane separated from the stroma in some local areas, stromal edema, and early vascularization. In group III, endothelial and epithelial cell layer loss, wrinkled Descemet and Bowman membranes, inflammatory cells, and structurally disturbed collagen bonds located beneath the Bowman membrane, and a greater amount of vascularization in the area of inflammation were observed.Conclusions:The results of the histologic evaluation of the decompensated corneas caused by the TASS are compatible with the clinical severity of the disease. In mild cases, the histologic findings were insignificant; however, when the clinical situation deteriorated, histologic findings became increasingly worse