35 research outputs found

    A nano-indentation study on the mechanical behaviour of the matrix material in an AA6061-Al2O3 MMC

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    The nano-indentation technique is a suitable technique to measure hardness and elastic moduli profiles of AA6061 reinforced with Al2O3 particles, since it allows measurements of mechanical properties on a micrometer range. To investigate possible local variations in mechanical behaviour of the matrix material due to precipitation reactions being affected by the presence of ceramic reinforcements, nano-indentation tests were done on both metal matrix composite (MMC) as well as unreinforced reference material, in three different heat treatment conditions. Matrix response depends on heat treatment condition, but is approximately equal for the MMC and the base reference alloy. Due to the various imposed heat treatments, magnesium enrichment around the ceramic particles was observed, but hardness and elastic modulus of this interfacial layer could not be measured. To confirm the preferential segregation of Mg near the particle/matrix interface, linescans were made with a Scanning Electron Microscope (SEM) equipped with EDS (Energy Dispersive Spectrum) facilities. The limited width of the Mg rich zone explains the absence of typical ''interphase'' indentations in this investigation. Hardly any differences in calculated elastic moduli and hardness values were found for the three heat treatment conditions investigated, when comparing results of AA6061 reference material with results of an AA6061 matrix in an MMC. This result is of great importance when modelling the mechanical behaviour of MMCs using the finite element method, since it permits the assumption that the MMC matrix material behaves similar to the same aluminium alloy without ceramic reinforcements

    Knowledge gaps in health-related quality of life research performed in children with bleeding disorders – A scoping review

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    Introduction: Bleeding disorders (BDs) may influence health-related quality of life (HRQoL) in children and caregivers. Measuring HRQoL gives insight into domains requiring support and provides an opportunity to evaluate the effects of novel therapies. Aim: To gain insight in the current body of literature on HRQoL in children with BDs in order to identify knowledge gaps for research and further development of this field. Methods: Scoping review. Results: We included 53 articles, describing studies mainly performed in Europe and North–America (60.4%) and mostly within the last ten years. Only 32% studies included children &lt;4 years. Almost all studies (47/53, 88.7%) were performed in boys with haemophilia, pooling haemophilia A and B (n = 21) and different disease severities (n = 20). Thirteen different generic and five disease-specific HRQoL-questionnaires were applied; all questionnaires were validated for haemophilia specifically. Six (11,3%) combined generic and disease-specific questionnaires. Self-reports were most frequently applied (40/53, 75.5%), sometimes combined with proxy and/or parent-reports (17/53, 32.1%). Eleven studies used a reference group (20.8%). Statistical analyses mostly consisted of mean and SD (77.4%).Conclusion: HRQoL-research is mainly performed in school-aged boys with haemophilia, treated in developed countries. Pitfalls encountered are the pooling of various BDs, subtypes and severities, as well as the application of multiple generic questionnaires prohibiting comparison of results. More attention is needed for broader study populations including other BDs, young children, feminine such as young children, feminine bleeding issues and platelet disorders, as well as the use of HRQoL as an effect-measurement tool for medical interventions, and more thorough statistical analysis.</p

    Knowledge gaps in health-related quality of life research performed in children with bleeding disorders – A scoping review

    Get PDF
    Introduction: Bleeding disorders (BDs) may influence health-related quality of life (HRQoL) in children and caregivers. Measuring HRQoL gives insight into domains requiring support and provides an opportunity to evaluate the effects of novel therapies. Aim: To gain insight in the current body of literature on HRQoL in children with BDs in order to identify knowledge gaps for research and further development of this field. Methods: Scoping review. Results: We included 53 articles, describing studies mainly performed in Europe and North–America (60.4%) and mostly within the last ten years. Only 32% studies included children &lt;4 years. Almost all studies (47/53, 88.7%) were performed in boys with haemophilia, pooling haemophilia A and B (n = 21) and different disease severities (n = 20). Thirteen different generic and five disease-specific HRQoL-questionnaires were applied; all questionnaires were validated for haemophilia specifically. Six (11,3%) combined generic and disease-specific questionnaires. Self-reports were most frequently applied (40/53, 75.5%), sometimes combined with proxy and/or parent-reports (17/53, 32.1%). Eleven studies used a reference group (20.8%). Statistical analyses mostly consisted of mean and SD (77.4%).Conclusion: HRQoL-research is mainly performed in school-aged boys with haemophilia, treated in developed countries. Pitfalls encountered are the pooling of various BDs, subtypes and severities, as well as the application of multiple generic questionnaires prohibiting comparison of results. More attention is needed for broader study populations including other BDs, young children, feminine such as young children, feminine bleeding issues and platelet disorders, as well as the use of HRQoL as an effect-measurement tool for medical interventions, and more thorough statistical analysis.</p

    Musa in fameia

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    Università degli Studi di Triest

    Formation of beach marks on alclad 2024-T3 sheet

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    Technische MateriaalwetenschappenApplied Science

    A nano-indentation study on the mechanical behaviour of the matrix material in an AA6061-Al2O3 MMC

    No full text
    The nano-indentation technique is a suitable technique to measure hardness and elastic moduli profiles of AA6061 reinforced with Al2O3 particles, since it allows measurements of mechanical properties on a micrometer range. To investigate possible local variations in mechanical behaviour of the matrix material due to precipitation reactions being affected by the presence of ceramic reinforcements, nano-indentation tests were done on both metal matrix composite (MMC) as well as unreinforced reference material, in three different heat treatment conditions. Matrix response depends on heat treatment condition, but is approximately equal for the MMC and the base reference alloy. Due to the various imposed heat treatments, magnesium enrichment around the ceramic particles was observed, but hardness and elastic modulus of this interfacial layer could not be measured. To confirm the preferential segregation of Mg near the particle/matrix interface, linescans were made with a Scanning Electron Microscope (SEM) equipped with EDS (Energy Dispersive Spectrum) facilities. The limited width of the Mg rich zone explains the absence of typical ''interphase'' indentations in this investigation. Hardly any differences in calculated elastic moduli and hardness values were found for the three heat treatment conditions investigated, when comparing results of AA6061 reference material with results of an AA6061 matrix in an MMC. This result is of great importance when modelling the mechanical behaviour of MMCs using the finite element method, since it permits the assumption that the MMC matrix material behaves similar to the same aluminium alloy without ceramic reinforcements

    Prolonged Continuous Heparin Treatment

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    A study into arribadas at Playa del Ostional: A field investigation into the seasonal morphological and hydrodynamical differences of the nesting beach, the involved stakeholders and the key parameters influencing the occurrence of an arribada

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    Arribadas, a phenomenon of mass nesting behavior of sea turtles, attract millions of olive ridley turtles (Lepidochelys olivacea) to Playa del Ostional, a nesting beach in Costa Rica. The timing and size of these arribadas are influenced by various environmental factors, including temperature, tides, and moon phase [1]. The sea turtles are threatened by a variety of factors, like amongst others climate change.Rising temperatures and sea levels, changes in ocean currents, and more frequent and intense storms are all likely to have negative impacts on sea turtles [2]. Without intervention, climate change could lead to the disappearance or flooding of sea turtle nesting beaches, resulting in a loss of critical habitat forthese creatures. To prevent such an outcome, it is imperative to gain a deeper understanding of the morphological and hydrodynamic characteristics of nesting beaches, as well as identify the factors that influence sea turtle nesting behavior.This study aimed to identify and map the critical factors that must be considered to ensure persistence of the olive ridley sea turtle and arribadas at Playa del Ostional, Costa Rica. The objectives of this research were, therefore, (1) to map the seasonal morphological and hydrodynamical differences of the arribada nesting beach, (2) to identify the environmental parameters that have the greatest influence on the occurrence of an arribada, and (3) to map out the stakeholders involved. The study site is the beach that ranges from the northernmost part of Playa del Ostional down to the southernmost part of Playa Nosara, which is located on the northern peninsula at the west coast of Costa Rica. The part at Playa del Ostional where most turtles nest is called ‘Main Nesting Beach’ (MNB). A field investigation was carried out to determine the seasonal morphological and hydrodynamical differences of the nesting beach. This field study comprised of two distinct components: (1) a characterization of the morpho- and hydrodynamics of Playa del Ostional in the dry season, and (2) a comparative analysis of these conditions during the wet and dry season. The morpho- and hydrodynamic beach characteristics consisted of the beach profile, sediment composition, hydrodynamic properties and other general environmental characteristics, such as vegetation and nearby rivers. The beach profile was measured by walking transects perpendicular to the shoreline using RTK-GPS equipment. Moreover, a drone was flown that made an orthophoto and collected 30 million data points. The difference in sediment composition was analyzed by obtaining sediment samples in the dry season, sieving these and comparing the obtained particle size distributions and D50 values of the dry and wet season. The hydrodynamical properties and the other general environmental characteristics are analyzed by means of literature review, observations and photography. In order to identify the environmental parameters that have the greatest influence on the occurrence on an arribada, an autoregressive logistic regression model was used. The model that was made the previous research of 2022, was updated and automated. Also, design choices of the model were made and new data was added.To map out the stakeholders, interviews have been conducted and a stakeholder map was created. Through the use of GPS transects the beach profiles taken in dry season (February 2023) were compared to wet season (October 2022). To tackle normal spacial variance the comparison is done through the calculation of averages on three beach stretches with equal characteristics. Main findings were that beach width is equal in both seasons, slopes are more gradual in dry season, beach plateaus are on average 3.0m wider in wet season. Crossing rivers do not influence the beach profile below waterline in the dry season. For more river characteristic more offshore research is needed. The sediment composition of the beach turned out to show significant differences between the dry and wet season. A significant difference is present in D50 values between the dry and wet season for almost all sediment samples. Moreover, during the wet season, the sediment tends to be coarser compared to the dry season. Additionally, during the dry season, coarser sediment tends to accumulate at the top of the slope, whereas during the wet season, coarser sediment accumulates near the waterline. These observations suggest that coarse sediment may move from areas close to the waterline to the submerged part of the slope over time. This behavior implies that sediment transportation is affected by the seasonal fluctuations in wave energy. The findings altogether indicate that the sediment composition at Playa del Ostional, particularly at Main Nesting Beach, is notably affected by seasonal changes. The impact is more pronounced from the low tide waterline to the high waterline’s end at the top of the slope, with a particular emphasis on the low tide waterline. The wave climate surrounding Playa del Ostional is expected to be less turbulent, with lower wave energy during the dry season. However, the exact distinctions in both wave climate and tidal surroundings between the two seasons cannot be ascertained due to inadequate data availability.The different stretches of Playa del Ostional demonstrate notable differences in environmental characteristics during the wet and dry seasons. The majority of rivers that flow out during the wet season are absent during the dry season. In addition, a beach scarp appeared during the dry season and not duringthe wet season, and an estuary that was observed in the dry season was not reported during the wet season research. On the other hand, the beach is mostly surrounded by vegetation in both seasons, with comparable grass and trees. Moreover, no significant difference in wildlife presence was observedbetween the dry and wet seasons at Playa del Ostional.The autoregressive logistic regression model was trained on five year of arribada data and 116 individual environmental parameters. The weights of the parameters were plotted and analysed in multiple groups. This resulted in six parameters with the biggest influence: pdTIDE_P1, pdTIDE_mf, pdVELOCITY_IHC_rho, pdVELOCITY_IHC_rho, Mooncycle_third and Moon_v. The maximum probability of an arribada occurring during a certain day was 80%.By conducting interviews and conducting a stakeholder analysis, the degree of awareness about climate change is assessed and mapped out, which appears to be quite high. The residents of Ostional are aware of the changes and willing to work in new projects. Moreover, the analysis showed that it is important toengage with two key stakeholders: the Refugio Nacional de Vida Silvestre Ostional and CITES.CIE4061-09 Multidisciplinary Projec
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