First principles study of adsorbed Cu_n (n=1-4) microclusters on MgO(100): structural and electronic properties

We present a density functional study of the structural and electronic properties of small Cu_n (n=1,4) aggregates on defect-free MgO(100). The calculations employ a slab geometry with periodic boundary conditions, supercells with up to 76 atoms, and include full relaxation of the surface layer and of all adsorbed atoms. The preferred adsorption site for a single Cu adatom is on top of an oxygen atom. The adsorption energy and Cu-O distance are E_S-A = 0.99 eV and d_S-A = 2.04 Angstroems using the Perdew-Wang gradient corrected exchange correlation functional. The saddle point for surface diffusion is at the "hollow" site, with a diffusion barrier of around 0.45 eV. For the adsorbed copper dimer, two geometries, one parallel and one perpendicular to the surface, are very close in energy. For the adsorbed Cu_3, a linear configuration is preferred to the triangular geometry. As for the tetramer, the most stable adsorbed geometry for Cu_4 is a rhombus. The adsorption energy per Cu atom decreases with increasing the size of the cluster, while the Cu-Cu cohesive energy increases, rapidly becoming more important than the adsorption energy.Comment: Major revision, Latex(2e) document, 23 pages, 11 figures, accepted for publication in J. of Chem. Phys., paper available at http://irrmawww.epfl.ch/vm/vm_wor

Numerical 3D simulation of a full system air core compulsator-electromagnetic rail launcher

Multiphysics problems represent an open issue in numerical modeling. Electromagnetic launchers represent typical examples that require a strongly coupled magnetoquasistatic and mechanical approach. This is mainly due to the high velocities which make comparable the electrical and the mechanical response times. The analysis of interacting devices (e.g., a rail launcher and its feeding generator) adds further complexity, since in this context the substitution of one device with an electric circuit does not guarantee the accuracy of the analysis. A simultaneous full 3D electromechanical analysis of the interacting devices is often required. In this paper a numerical 3D analysis of a full launch system, composed by an air-core compulsator which feeds an electromagnetic rail launcher, is presented. The analysis has been performed by using a dedicated, in-house developed research code, named "EN4EM" (Equivalent Network for Electromagnetic Modeling). This code is able to take into account all the relevant electromechanical quantities and phenomena (i.e., eddy currents, velocity skin effect, sliding contacts) in both the devices. A weakly coupled analysis, based on the use of a zero-dimensional model of the launcher (i.e., a single loop electrical equivalent circuit), has been also performed. Its results, compared with those by the simultaneous 3D analysis of interacting devices, show an over-estimate of about 10-15% of the muzzle speed of the armature

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

Electromechanical Numerical Analysis of an Air-Core Pulsed Alternator via Equivalent Network Formulation

In this paper, the numerical analysis on an air-core pulsed alternator is presented. Since compulsators are characterized by very fast electromechanical transients, their accurate analysis requires strong coupling between the equations governing the electrical and the mechanical behaviors. The device is investigated by using a dedicated numerical code capable to take into account eddy currents, compensating windings, as well as the excitation/control circuits. Furthermore, the code is capable of modeling centrifugal forces and vibrations acting on the shaft due to electric and mechanical unbalances or to misalignments of the shaft from its centered position. This makes the code a very powerful tool during the design phase. Examples of application of the code to machines with nonuniform compensating shield and with shorted compensating windings are shown

Valuation of ecological retrofitting technology in existing buildings: A real-world case study

The world’s existing buildings are aged, in a state of deterioration and in need of inter-ventions. When selecting the type of possible intervention to be applied, the choice falls between two alternatives: simple unsustainable ordinary maintenance versus ecological retrofitting i.e., an increase in the quality of the indoor environment and building energy saving using local bio-natural materials and products. The present research seeks to respond to the requests of recent comprehen-sive reviews which ask for the retrofitting of the world’s huge existing building stocks and portfolios by proposing an approach and testing it in a specific case study (at the unit, building and urban block level) which can then be carried out and repeated in the future on a larger urban scale. The real-world experimentation in the provided case study achieved the important outcome and goal of a Green Building strategy and post-carbon city framework i.e. the significant enhancement of the thermal performance of the buildings as a result of a few targeted key external works and the con-sequent saving of energy in those already existing (but not preserved and not included in the state national register or record of monuments) Liberty-style constructions. All the above show that these important existing buildings can be ecologically retrofitted at an affordable cost, although initially slightly more expensive than the cost of ordinary unsustainable maintenance. However, this difference is offset by the favorable pay-back period, which is fast, acceptable and of short duration. The tried and tested approach, the positive proposed case study and the experimental database-GIS joint platform (the details of which can be found in an additional supplementary research which is currently being carried out) are the bases on which a future decision support system will be proposed. This support system can be carried out as a tailor-made solution for the ecological retrofitting of the enormous existing building stocks and portfolios which must be considered on a larger scale i.e., at ward, quartier, city, regional and country level

P365Protection against doxorubicine-induced cardiomyopathy by bergamot polyphenols through myocyte survival and cardiac stem cell activation

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