Natural Intelligence and Anthropic Reasoning

This paper aims to justify the concept of natural intelligence in the biosemiotic context. I will argue that the process of life is (i) a cognitive/semiotic process and (ii) that organisms, from bacteria to animals, are cognitive or semiotic agents. To justify these arguments, the neural-type intelligence represented by the form of reasoning known as anthropic reasoning will be compared and contrasted with types of intelligence explicated by four disciplines of biology – relational biology, evolutionary epistemology, biosemiotics and the systems view of life – not biased towards neural intelligence. The comparison will be achieved by asking questions related to the process of observation and the notion of true observers. To answer the questions I will rely on a range of established concepts including SETI (search for extraterrestrial intelligence), Fermi’s paradox, bacterial cognition, versions of the panspermia theory, as well as some newly introduced concepts including biocivilisations, cognitive/semiotic universes, and the cognitive/semiotic multiverse. The key point emerging from the answers is that the process of cognition/semiosis – the essence of natural intelligence – is a biological universal.Brunel University Londo

Harnessing behavioral diversity to understand neural computations for cognition

With the increasing acquisition of large-scale neural recordings comes the challenge of inferring the computations they perform and understanding how these give rise to behavior. Here, we review emerging conceptual and technological advances that begin to address this challenge, garnering insights from both biological and artificial neural networks. We argue that neural data should be recorded during rich behavioral tasks, to model cognitive processes and estimate latent behavioral variables. Careful quantification of animal movements can also provide a more complete picture of how movements shape neural dynamics and reflect changes in brain state, such as arousal or stress. Artificial neural networks (ANNs) could serve as artificial model organisms to connect neural dynamics and rich behavioral data. ANNs have already begun to reveal how a wide range of different behaviors can be implemented, generating hypotheses about how observed neural activity might drive behavior and explaining diversity in behavioral strategies

Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation

Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor functions, rather than compensatory acquisition of new movements

Implications of weighting factors on technology preference in net zero energy buildings

With the current movement towards Net Zero Energy Buildings (Net ZEBs) decisions regarding energy carrier weighting factors will have implications on which technologies could be favoured or disfavoured, and therefore adopted or not adopted, in the building sector of the near future. These implications should be taken into consideration by policy makers when developing legislation and regulations addressing the building sector. A parametric analysis was conducted on six buildings in Europe of different typologies and climates in order to assess how different weighting factors would impact the choice of technical systems to be installed. For each combination the amount of PV capacity necessary to achieve a net zero balance has been calculated and used as the main indicator for comparison; where less PV area means more favourable condition. The effect of including a solar thermal system is also discussed. With the current European national weighting factors, biomass boiler is largely the preferred solution, frequently achieving the balance with PV installed on the roof, while gas boiler is the most penalized. The situation changes when strategic weighting factors are applied. Lower weighting factors for electricity and district heating, e.g. reflecting national targets of increased penetration of renewables in such grids, would promote the use of heat pump and district heating, respectively. Asymmetric factors aimed at rewarding electricity export to the grid would facilitate the achievement of the zero balance for all technologies, promoting cogeneration in some cases. On the contrary, low weighting factors for electricity, e.g. reflecting a scenario of high decarbonisation of the power system, prove quite demanding; only few technical solutions would be able to reach the balance within the available roof area for PV, because of the low value credited to exported electricity. In this situation, the preferred solution would be heat pumps combined with solar thermal. In addition, the choice of weighting factors and the resulting favoured technologies will determine the temporal matching of load and generation. While all-electric solutions tend to use the grid as seasonal storage, other solutions will have a yearly net export of electricity to the grid to compensate for the supply of other (thermal) energy carriers. Therefore, it is important to consider the implications for the electricity grid resulting from the choice of weighting factors. (C) 2014 Elsevier B.V. All rights reserved

Oxidative stress induces BH4 deficiency in male, but not female, SHR

We previously published that female spontaneously hypertensive rats (SHR) have significantly greater nitric oxide (NO) bioavailability and NO synthase (NOS) enzymatic activity in the renal inner medulla (IM) compared with age-matched males, although the mechanism responsible remains unknown. Tetrahydrobiopterin (BH4) is a critical cofactor required for NO generation, and decreases in BH4 as a result of increases in oxidative stress have been implicated in the pathogenesis of hypertension. As male SHR are known to have higher levels of oxidative stress compared with female SHR, we hypothesized that relative BH4 deficiency induced by oxidative stress in male SHR results in lower levels of NOS activity in renal IM compared with females. Twelve-week-old male and female SHR were randomized to receive tempol (30 mg/kg/day via drinking water) or vehicle for 2 weeks. Tempol treatment did not affect blood pressure (BP) in either sex, but reduced peroxynitrite levels only in males. Females had more total biopterin, dihydrobiopterin (BH2), and BH4 levels in renal IMs than males, and tempol treatment eliminated these sex differences. Females had greater total NOS activity in the renal IM than males, and adding exogenous BH4 to the assay increased NOS activity in both sexes. This sex difference in total NOS and the effect of exogenous BH4 were abolished with tempol treatment. We conclude that higher oxidative stress in male SHR results in a relative deficiency of BH4 compared with females, resulting in diminished renal NOS activity in the male.NIH [HL127091]; AHA [17EIA33410565]Open access journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]