449 research outputs found

    Technology-enabled Active Learning (TEAL) – A Study of its Influence on Student Learning

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    Using an active learning framework proposed by Shroff et al (2019), our study evaluates the impact of technology-enabled active learning (TEAL) on student learning in an Australian business school, using the individual reflections of accounting students as data collection strategy. We found positive influence of the three constructs of the framework - interactive engagement, problem solving and feedback on learning. Our study found interactive engagement, development of problem-solving skills and individualized learning context enabled by accounting technology have positively contributed to the learning effectiveness. Technology-enhanced scaffolds designed in the learning process have contributed to the consolidation of learning and to learning effectiveness. Our study observed that though students’ interest and curiosity enabled by technology is expected to have positive influence on learning, lack of student effort, poor timing of feedback, and absence of a sense of challenge, have limited their learning

    Indirect Estimation of Selected Measures of Fertility and Marital Fertility from Information on CWR (0-9): An Application to India /States /Districts

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    Fertility is one of the important components of population change, the other two being mortality and migration. When vital statistical data on number of births is readily available it is estimated directly using various direct measures of fertility such as the crude birth rate (CBR). When the information on number of births is not directly available, fertility is measured using the census information on child woman ratios (CWR) of various types. CWR has several limitations, but gained importance with the attempts made by Rele in 1963, and followed by several other researchers such as Hauer and his co-authors in 2013 deriving TFR from it. In the present study yet another attempt is made to use CWRs to derive not only TFR but also other summary indicators such as the TMFR. A set of simple mathematical formula have been used to estimate the fertility and marital fertility using the CWR of the ages 0-9. The 2011 census age-sex data of districts in India was used to derive a set of fertility estimates for total, rural and urban areas of all districts. Further, these estimates of 2011 have been compared with the estimates of 2011 earlier made by Guilmoto and Rajan to analyse the robustness of the estimates.Keywords: Fertility, Child Women Ratio, Indirect Estimation, Age-sex data, TFR, TMFR, India

    Sec6 mutations and the Drosophila exocyst complex

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    To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila. We have used these mutations to compare the phenotypes of sec6 and sec5 in the ovary and nervous system, and we find them to be similar. We also find that Sec5 is mislocalized in sec6 mutants. Additionally, we have generated an epitope-tagged Sec8 that localized with Sec5 on oocyte membranes and was mislocalized in sec5 and sec6 germ-line clones. This construct further revealed a genetic interaction of sec8 and sec5. These data, taken together, provide new information about the organization of the exocyst complex and suggest that Sec5, Sec6 and Sec8 act as a complex, each member dependent on the others for proper localization and function

    Simple, Rapid and Validated LC Determination of Lopinavir in Rat Plasma and its Application in Pharmacokinetic Studies

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    Lopinavir is a new specific and potent HIV-1 protease inhibitor. A simple and rapid Reverse Phase High-Performance Liquid Chromatographic method using UV detection was developed and validated for the analysis of lopinavir in rat plasma under isocratic conditions. The method involves a single step protein precipitation technique. The detector response was linear over the concentration range of 250 to 4000 ng mL −1. High recovery ranging from 97.5 to 101.2 percent was obtained which precludes the use of internal standard. The developed method was validated as per standard guidelines. Validation of the developed method demonstrated accuracy, precision and selectivity of the proposed method. The drug was found to be stable under various processing and storage conditions. This rapid and cost-effective method was successfully applied in the estimation of lopinavir and determination of various pharmacokinetic parameters during post intravenous bolus administration of the drug in rats. The developed method can be suitably employed in preclinical pharmacokinetic evaluation of new formulations designed to improve the bioavailability of lopinavir
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