17 research outputs found
Principal component analysis (PCA) of 5090 samples (glaucoma cases and controls) from eMERGE network.
<p>Eigenvector 1 is on x-axis and eigenvector 2 is on y-axis. Each point is a sample and they are color coded by case and control status.</p
Flow chart explaining all the steps for gene based interaction analysis in discovery (eMERGE) and replication dataset (NEIGHBOR).
<p>Flow chart explaining all the steps for gene based interaction analysis in discovery (eMERGE) and replication dataset (NEIGHBOR).</p
(A) The association signal between total serum ALP and the ABO blood locus. (B): The association of lead SNPs at the ABO locus with serum ALP and their relation with ABO tag SNPs (rs8176746, rs8176704, rs505922); A significant drop in association effect in lead SNPs after controlling for ABO-tag SNPs are shown (red and black dots represent before and after conditional analyses respectively).
<p>(A) The association signal between total serum ALP and the ABO blood locus. (B): The association of lead SNPs at the ABO locus with serum ALP and their relation with ABO tag SNPs (rs8176746, rs8176704, rs505922); A significant drop in association effect in lead SNPs after controlling for ABO-tag SNPs are shown (red and black dots represent before and after conditional analyses respectively).</p
Hierarchal plot showing 16 genes in red circles and 11 pathways in blue rectangles.
<p>Connection between the genes and pathways was established using Biofilter 2.0.</p
Quantitative and case-control association result of top SNPs in UGT1A1 for total serum bilirubin levels in pediatric and adult subgroups.
<p>*Map Position: NCBI build 37.</p><p>†linear regression association test.</p><p>‡Chi-square test.</p><p>Quantitative and case-control association result of top SNPs in UGT1A1 for total serum bilirubin levels in pediatric and adult subgroups.</p
POAG GWAS Results in eMERGE dataset.
<p><b>(A)</b> Manhattan plot shows chromosome and base pair positions on x-axis and -log10 of p-value on y-axis. Each point here represents a SNP. Red line is the genome-wide significance line at 5e-08. Highlighted points indicate annotation of SNPs with previously reported GWAS associated genes. <b>(B)</b> Shows a QQ-plot from GWAS analysis.</p
Heat map representing expression of the unique genes found in the ocular tissue database from GXG interaction results.
<p>Here, the x-axis lists all genes and y-axis lists the names of 10 tissues from the eye. Scale and color intensity represent PLIER values as reported in the ocular tissue database.</p
Circular plot representing only unique gene-gene interactions.
<p>Genes are colored as red if they are expressed in eye and as grey if not expressed in the eye. All genes are ordered by chromosome. Links between the genes represent gene-gene interactions that are replicated.</p
Synthesis view plot representing unique gene-gene interaction models and their p-values in discovery and replication dataset.
<p>Synthesis view plot representing unique gene-gene interaction models and their p-values in discovery and replication dataset.</p
A schematic representation of association map at UGT1A region for total serum bilirubin.
<p>The TA repeat location is shown with vertical line.</p