12 research outputs found

    Supplemental_Material_2.6.18 – Supplemental material for Facial Affect and Interpersonal Affiliation: Displays of Emotion During Relationship Formation in Social Anxiety Disorder

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    Supplemental material, Supplemental_Material_2.6.18 for Facial Affect and Interpersonal Affiliation: Displays of Emotion During Relationship Formation in Social Anxiety Disorder by Sarah L. Pearlstein, Charles T. Taylor and Murray B. Stein in Clinical Psychological Science</p

    CJP_AUD_Supplementary_Table - Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada

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    CJP_AUD_Supplementary_Table for Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada by Tamara L. Taillieu, Tracie O. Afifi, Mark A. Zamorski, Sarah Turner, Kristene Cheung, Murray B. Stein and Jitender Sareen in The Canadian Journal of Psychiatry</p

    CJP_AUD_Supplementary_Table - Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada

    No full text
    CJP_AUD_Supplementary_Table for Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada by Tamara L. Taillieu, Tracie O. Afifi, Mark A. Zamorski, Sarah Turner, Kristene Cheung, Murray B. Stein and Jitender Sareen in The Canadian Journal of Psychiatry</p

    Supplemental Material, Revised_CJP_AUD_Manuscript_Oct_31_2019.docx-clean - Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada

    No full text
    Supplemental Material, Revised_CJP_AUD_Manuscript_Oct_31_2019.docx-clean for Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada by Tamara L. Taillieu, Tracie O. Afifi, Mark A. Zamorski, Sarah Turner, Kristene Cheung, Murray B. Stein and Jitender Sareen in The Canadian Journal of Psychiatry</p

    sj-docx-1-phr-10.1177_00333549221149092 – Supplemental material for Stressful Life Events and Risk of Homelessness After Active Duty: An Assessment of Risk and Resilience Among Servicemembers

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    Supplemental material, sj-docx-1-phr-10.1177_00333549221149092 for Stressful Life Events and Risk of Homelessness After Active Duty: An Assessment of Risk and Resilience Among Servicemembers by Ann Elizabeth Montgomery, Katherine A. Koh, Andrew J. King, Robert O’Brien, Nancy A. Sampson, Aldis Petriceks, Murray B. Stein, Robert J. Ursano and Ronald C. Kessler in Public Health Reports</p

    Kessler_Supplemental_Material – Supplemental material for Developing a Risk Model to Target High-Risk Preventive Interventions for Sexual Assault Victimization Among Female U.S. Army Soldiers

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    Supplemental material, Kessler_Supplemental_Material for Developing a Risk Model to Target High-Risk Preventive Interventions for Sexual Assault Victimization Among Female U.S. Army Soldiers by Amy E. Street, Anthony J. Rosellini, Robert J. Ursano, Steven G. Heeringa, Eric D. Hill, John Monahan, James A. Naifeh, Maria V. Petukhova, Ben Y. Reis, Nancy A. Sampson, Paul D. Bliese, Murray B. Stein, Alan M. Zaslavsky and Ronald C. Kessler in Clinical Psychological Science</p

    Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene <i>BHLHE22</i>

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    Major Depressive Disorder (MDD) is a complex neuropsychiatric disease with known genetic associations, but without known links to rare variation in the human genome. Here we aim to identify rare genetic variants associated with MDD using deep whole-genome sequencing data in an independent population. We report the sequencing of 1,688 whole genomes in a large sample of male-male Veteran twins. Depression status was classified based on a structured diagnostic interview according to DSM-III-R diagnostic criteria. Searching only rare variants in genomic regions from recent GWAS on MDD, we used the optimised sequence kernel association test and Fisher's Exact test to fine map loci associated with severe depression. Our analysis identified one gene associated with severe depression, basic helix loop helix e22 (PAdjusted = 0.03) via SKAT-O test between unrelated severely depressed cases compared to unrelated non-depressed controls. The same gene BHLHE22 had a non-silent variant rs13279074 (PAdjusted = 0.032) based on a single variant Fisher’s Exact test between unrelated severely depressed cases compared to unrelated non-depressed controls. The gene BHLHE22 shows compelling genetic evidence of directly impacting the severe depression phenotype. Together these results advance understanding of the genetic contribution to major depressive disorder in a new cohort and link a rare variant to severe forms of the disorder.</p
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