6,460 research outputs found

    The position and role of the ecclesiastical bailie in late fifteenth and early sixteenth century Scotland

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    This thesis takes the form of an examination of the office of ecclesiastical bailie in Scotland in the late fifteenth and early sixteenth centuries. The office, in origin and in essence, was legal and judicial, but in the fifteenth century the principal role of the bailie came increasingly to be one of defence of ecclesiastical land and privilege. The office existed at all levels in the Church, from large monastery to small chapel, and normally came to be held by men of noble class. As with most medieval offices it tended to become hereditary in a particular family. It was a source of considerable economic gain to the nobility, to judge by the rush all over Scotland to secure its possession. Indeed possession of an ecclesiastical bailiary could be one step on the road to the secularisation of Church lands in the post- Reformation period and may have acted as a social catalyst which allowed many of Scotland's middling noble families to reach the highest echelons of the nobility. The office was not purely Scottish and was to be found throughout Europe at this time. As far as may be determined, no extensive research has been done on the equivalents for any other European country, and it is hoped that this may be the first of many studies into the significance of the office in late medieval ecclesiastical history

    Communication and re-use of chemical information in bioscience.

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    The current methods of publishing chemical information in bioscience articles are analysed. Using 3 papers as use-cases, it is shown that conventional methods using human procedures, including cut-and-paste are time-consuming and introduce errors. The meaning of chemical terms and the identity of compounds is often ambiguous. valuable experimental data such as spectra and computational results are almost always omitted. We describe an Open XML architecture at proof-of-concept which addresses these concerns. Compounds are identified through explicit connection tables or links to persistent Open resources such as PubChem. It is argued that if publishers adopt these tools and protocols, then the quality and quantity of chemical information available to bioscientists will increase and the authors, publishers and readers will find the process cost-effective.An article submitted to BiomedCentral Bioinformatics, created on request with their Publicon system. The transformed manuscript is archived as PDF. Although it has been through the publishers system this is purely automatic and the contents are those of a pre-refereed preprint. The formatting is provided by the system and tables and figures appear at the end. An accommpanying submission, http://www.dspace.cam.ac.uk/handle/1810/34580, describes the rationale and cultural aspects of publishing , abstracting and aggregating chemical information. BMC is an Open Access publisher and we emphasize that all content is re-usable under Creative Commons Licens

    Chemistry in Bioinformatics

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    A preprint of an invited submission to BioMedCentral Bioinformatics. This short manuscript is an overview or the current problems and opportunities in publishing chemical information. Full details of technology are given in the sibling manuscript http://www.dspace.cam.ac.uk/handle/1810/34579 The manuscript is the authors' preprint although it has been automatically transformed into this archived PDF by the submission system. The authors are not responsible for the formattingChemical information is now seen as critical for most areas of life sciences. But unlike Bioinformatics, where data is Openly available and freely re−usable, most chemical information is closed and cannot be re−distributed without permission. This has led to a failure to adopt modern informatics and software techniques and therefore paucity of chemistry in bioinformatics. New technology, however, offers the hope of making chemical data (compounds and properties) Free during the authoring process. We argue that the technology is already available; we require a collective agreement to enhance publication protocols

    Design and Evaluation of a Probabilistic Music Projection Interface

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    We describe the design and evaluation of a probabilistic interface for music exploration and casual playlist generation. Predicted subjective features, such as mood and genre, inferred from low-level audio features create a 34- dimensional feature space. We use a nonlinear dimensionality reduction algorithm to create 2D music maps of tracks, and augment these with visualisations of probabilistic mappings of selected features and their uncertainty. We evaluated the system in a longitudinal trial in users’ homes over several weeks. Users said they had fun with the interface and liked the casual nature of the playlist generation. Users preferred to generate playlists from a local neighbourhood of the map, rather than from a trajectory, using neighbourhood selection more than three times more often than path selection. Probabilistic highlighting of subjective features led to more focused exploration in mouse activity logs, and 6 of 8 users said they preferred the probabilistic highlighting mode

    FAST.Q: feedback and answer system technology for questions

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    As is common in the standard lecture format, students rarely ask questions when seeking clarification or further understanding of a topic. Whatever the underlying reason for this may be, it certainly poses a problem for the lecturers delivering these lectures due to the difficultly in determining the cohorts' current understanding of the materials. This paper presents a system (FAST.Q) designed to encourage students to feel more able and comfortable to ask questions and provide lecture feedback in real-time, allowing the lecturer to answer these questions for the benefit of the student and the whole class. In this paper the prototype system is presented, with the feedback of the initial trials. The usability and applicability of the system is then presented and evaluated

    Review: Marine natural products

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    This review covers the literature published in 2003 for marine natural products, with 619 citations (413 for the period January to December 2003) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds (656 for 2003), together with their relevant biological activities, source organisms and country of origin. Biosynthetic studies or syntheses that lead to the revision of structures or stereochemistries have been included (78), including any rst total syntheses of a marine natural product

    Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis?:The CLOTS 3 trial: statistical analysis plan

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    BACKGROUND: Venous thromboembolism (VTE) is a common and important complication of stroke. The CLOTS 3 trial aims to determine whether, compared with best medical care, best medical care plus intermittent pneumatic compression (IPC) in immobile stroke patients reduces the risk of proximal deep vein thrombosis (DVT). METHODS/DESIGN: The CLOTS 3 trial is a multicenter, parallel group trial with centralized randomization (minimization) to ensure allocation concealment. The protocol has been published (Trials 2012, 13:26) and is available in full at: http://www.clotstrial.com. Between December 2008 and September 2012, 105 centers in the UK recruited 2,876 immobile stroke patients within the first 3 days of their hospital admission. Patients were allocated to best medical care or best medical care plus IPC. Ultrasonographers performed a compression Doppler ultrasound scan to detect DVT in each treatment group at 7 to 10 days and 25 to 30 days. The primary outcome cluster includes symptomatic or asymptomatic DVT in the popliteal or femoral veins detected on either scan. Patients will be followed up by postal or telephone questionnaire at 6 months from randomization to detect later symptomatic DVT and pulmonary embolism (PE), and to measure functional outcome (Oxford Handicap Scale) and quality of life (EQ-5D-3L). The ultrasonographers performing the scans are blinded to treatment allocation, whereas the patients and caregivers are not. The trial has more than 90% power to detect a 4% absolute difference (12% versus 8%) in risk of the primary outcome and includes a health economic analysis. Follow-up will be completed in April 2013 and the results reported in May 2013. In this update, we describe the statistical analysis plan. TRIAL REGISTRATION: ISRCTN: ISRCTN9352999

    ISIS2: Pixel Sensor with Local Charge Storage for ILC Vertex Detector

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    ISIS (In-situ Storage Imaging Sensor) is a novel CMOS sensor with multiple charge storage capability developed for the ILC vertex detector by the Linear Collider Flavour Identification (LCFI) collaboration. This paper reports test results for ISIS2, the second generation of ISIS sensors implemented in a 0.18 micron CMOS process. The local charge storage and charge transfer were unambiguously demonstrated.Comment: 11 pages, 16 figures, to be included in the Proceedings of International Linear Collider Workshop 201
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