Design and Testing of a Low-Cost and Low-Maintenance Drip Irrigation Filtration System for Micro-Irrigation in Developing Countries

The cylindrical filters presently used in <1000 m2 drip irrigation systems are frequently clogged, increasing pressure loss and lowering the flow rate through the filters. This work investigates the mechanisms for this clogging and proposes an alternative filtration design that would enable both more reliable and lower maintenance filtering. This proposed system is compatible with existing drip irrigation systems and could be made inexpensively with plastic bottle manufacturing equipment. To compare the proposed design to off-the-shelf options, a drip irrigation test setup was built to measure the pressure loss across different filters as particles accumulated. These experiments confirmed that pleated cartridge filters, with high effective surface area, incurred lower pressure losses than cylindrical filters. These tests revealed that the greatest reason for clogged performance was that filtered particles (not the cartridge filter itself) eventually restricted the flow of water through the system. This inspired the redesign of the filter housing such that the housing extended far below the filter, providing a catch basin away from the filter for the particles to settle. Fixing the filter independently of the bottom casing significantly improved the overall performance of the filtration system, reduced the maintenance requirement necessary from the user, and would enable inexpensive manufacturing via blow molding. This paper experimentally demonstrates that the cartridge filter inside the redesigned housing can filter out over 2 kg of sand while maintaining less than a .03 bar pressure drop across the filter at a flow rate of 25 l/s.Massachusetts Institute of Technology. Tata Center for Technology and DesignMassachusetts Institute of Technology. Department of Mechanical Engineerin

Delivering a low-cost, reliable drip irrigation filtration system for micro-irrigation in developing countries

The cylindrical filters presently used in drip irrigation systems frequently clog, increasing pressure loss and lowering the flow rate through the filters. This work investigates alternative filtration strategies that increase the reliability of, and are compatible with, existing systems. To test different filtration strategies, a drip irrigation test setup was built to measure the pressure loss across different filters as particles accumulated. These experiments found that pleated cartridge filters, with high effective surface area, incurred the lowest pressure losses. More significantly, it was observed during these tests that the filtered out particles settled to the bottom of the filter housing when flow through the filter ceased. This inspired the redesign of the filter housing such that the housing extended far below the filter, providing a catch basin away from the filter for the particles to settle. Fixing the filter independently of the bottom casing significantly improves the overall performance of the filtration system and can be inexpensively manufactured via blow molding. This paper experimentally demonstrates that the cartridge filter inside the redesigned housing can filter out over 2 kg of sand while maintaining less than a .03 bar pressure drop across the filter at a flow rate of 25 l/s.MIT Tata Center for Technology and DesignMassachusetts Institute of Technology. Department of Mechanical EngineeringInternational Development Enterprise

Can children undergoing ophthalmologic examinations under anesthesia be safely anesthetized without using an IV line?

To document that with proper patient and procedure selection, children undergoing general inhalational anesthesia for ophthalmologic exams (with or without photos, ultrasound, laser treatment, peri-ocular injection of chemotherapy, suture removal, and/or replacement of ocular prosthesis) can be safely anesthetized without the use of an intravenous (IV) line. Children are rarely anesthetized without IV access placement. We performed a retrospective study to determine our incidence of IV access placement during examinations under anesthesia (EUA) and the incidence of adverse events that required intraoperative IV access placement. Data collected from our operating room (OR) information system includes but is not limited to diagnosis, anesthesiologist, surgeon, and location of IV catheter (if applicable), patient's date of birth, actual procedure, and anesthesia/procedure times. We reviewed the OR and anesthetic records of children (>1 month and <10 years) who underwent EUAs between January 1, 2003 and May 31, 2009. We determined the percentage of children who were anesthetized without IV access placement, as well as the incidence of any adverse events that required IV access placement, intraoperatively. We analyzed data from 3196 procedures performed during a 77-month period. Patients' ages ranged from 1 month to 9 years. Overall, 92% of procedures were performed without IV access placement. Procedure duration ranged from 1-39 minutes. Reasons for IV access placement included parental preference for antinausea medication and/or attending preference for IV access placement. No child who underwent anesthesia without an IV line had an intraoperative adverse event requiring insertion of an IV line. Our data suggest that for children undergoing general anesthesia for ophthalmologic exams (with or without photos, ultrasound, laser treatment, intraocular injection of chemotherapy, suture removal, and/or replacement of ocular prosthesis), anesthesia can be safely conducted without placement of an IV line

Long-Term Followup Comparing Two Treatment Dosing Strategies of 125

Objective. To investigate the efficacy of two different dosing strategies of radioactive iodine-125 (125I) in the management of small- and medium-sized posterior uveal melanoma. Patients and Methods. The medical records of consecutive patients with choroidal melanomas between 1.5 and 5.0 mm in apical height treated initially with 125I plaque radiotherapy were reviewed. Patients were treated with one of the following two treatment dosing strategies: (1) 85 Gy to the apical height of the tumor (group 1) or (2) 85 Gy to a prescription point of 5.0 mm (group 2). Results. Of 95 patients, 55 patients were treated to the apical height of the tumor, and 40 were treated to a prescription point of 5.0 mm. Comparative analysis of the incidence rates of specific complications between the two groups demonstrates that group 2 had a significantly higher incidence of radiation retinopathy, radiation optic neuropathy, and/or visually significant cataract formation than group 1 (). Conclusion. Treatment of choroidal melanomas less than 5 mm in apical height with 125I brachytherapy to the true apical height is equally effective when compared to treatment with 85 Gy to 5.0 mm. Treatment to the apical height of the tumor may result in lower incidence of radiation-related complications

HST Observations of Chromospheres in Metal Deficient Field Giants

HST high resolution spectra of metal-deficient field giants more than double the stars in previous studies, span about 3 magnitudes on the red giant branch, and sample an abundance range [Fe/H]= -1 to -3. These stars, in spite of their age and low metallicity, possess chromospheric fluxes of Mg II (2800 Angstrom) that are within a factor of 4 of Population I stars, and give signs of a dependence on the metal abundance at the lowest metallicities. The Mg II k-line widths depend on luminosity and correlate with metallicity. Line profile asymmetries reveal outflows that occur at lower luminosities (M_V = -0.8) than detected in Ca K and H-alpha lines in metal-poor giants, suggesting mass outflow occurs over a larger span of the red giant branch than previously thought, and confirming that the Mg II lines are good wind diagnostics. These results do not support a magnetically dominated chromosphere, but appear more consistent with some sort of hydrodynamic, or acoustic heating of the outer atmospheres.Comment: 36 pages, 12 figures, 7 tables, and accepted for publication in The Astronomical Journa

The enigmatic multiple star VV Ori

New photometry, including TESS data, have been combined with recent spectroscopic observations of the Orion Ib pulsating triple-star system VV Ori. This yields a revised set of absolute parameters with increased precision. Two different programs were utilized for the light curve analysis, with results in predictably close agreement. The agreement promotes confidence in the analysis procedures. The spectra were analysed using the {\sc FDBinary} program. The main parameters are as follows: $M_1 = 11.6 \pm 0.14$ and $M_2 = 4.8 \pm 0.06$ (M$_\odot$). We estimate an approximate mass of the wide companion as $M_3 = 2.0 \pm 0.3$ M$_\odot$. Similarly, $R_{1} = 5.11 \pm 0.03$, $R_2 = 2.51 \pm 0.02$, $R_3 = 1.8 \pm 0.1$ (R$_\odot$); $T_{\rm e 1} = 26600 \pm 300$, $T_{\rm e 2} = 16300 \pm 400$ and $T_{\rm e 3} = 10000 \pm 1000$ (K). The close binary's orbital separation is $a= 13.91$ (R$_\odot$); its age is $8 \pm 2$ (Myr) and its photometric distance is $396 \pm 7$ pc. The primary's $\beta$ Cep type oscillations support these properties and confirm our understanding of its evolutionary status. Examination of the well-defined $\lambda$6678 He I profiles reveals the primary to have a significantly low projected rotation: some 80\% of the synchronous value. This can be explained on the basis of the precession of an unaligned spin axis. This proposal can resolve also observed variations of the apparent inclination and address other longer-term irregularities of the system reported in the literature. This topic invites further observations and follow-up theoretical study of the dynamics of this intriguing young multiple star.Comment: 17 pages, 15 figures, 14 tables, accepted by MNRA

Retinoblastoma treatment: impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LHBETATAG retinal tumors

Purpose: The purpose of this study was to evaluate the effect of 2-deoxy-D-glucose (2-DG) on the spatial distribution of the genetic expression of key elements involved in angiogenesis, hypoxia, cellular metabolism, and apoptosis in LHBETATAG retinal tumors. Methods: The right eye of each LHBETATAG transgenic mouse (n = 24) was treated with either two or six subconjunctival injections of 2-DG (500 mg/kg) or saline control at 16 weeks of age. A gene expression array analysis was performed on five different intratumoral regions (apex, center, base, anterior-lateral, and posterior-lateral) using Affymetrix GeneChip Mouse Gene 1.0 ST arrays. To test for treatment effects of each probe within each region, a two-way analysis of variance was used. Results: Significant differences between treatment groups (ie, 0, 2, and 6 injections) were found as well as differences among the five retinal tumor regions evaluated (P \u3c 0.01). More than 100 genes were observed to be dysregulated by ≥2-fold difference in expression between the three treatment groups, and their dysregulation varied across the five regions assayed. Several genes involved in pathways important for tumor cell growth (ie, angiogenesis, hypoxia, cellular metabolism, and apoptosis) were identified. Conclusions: 2-DG was found to significantly alter the gene expression in LHBETATAG retinal tumor cells according to their location within the tumor as well as the treatment schedule. 2-DG’s effects on genetic expression found here correlate with previous reported results on varied processes involved in its in vitro and in vivo activity in inhibiting tumor cell growth