Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting

This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this special issue also describes a wider array of mTOR-driven biological processes that cancer cells benefit from, including autophagy, cell cycle control, metabolic transformation, angiogenic signaling, and anabolic processes such as nucleotide biosynthesis and ribosomal biogenesis. Other areas of mTOR signaling covered in these reviews delve into cell migration, inflammation, and regulation of transcription factors linked to cancer progression

Predicting Dust Distribution in Protoplanetary Discs

We present the results of three-dimensional numerical simulations that include the effects of hydrodynamical forces and gas drag upon an evolving dusty gas disk. We briefly describe a new parallel, two phase numerical code based upon the smoothed particle hydrodynamics (SPH) technique in which the gas and dust phases are represented by two distinct types of particles. We use the code to follow the dynamical evolution of a population of grains in a gaseous protoplanetary disk in order to understand the distribution of grains of different sizes within the disk. Our ``grains'' range from metre to submillimetre in size.Comment: 2 pages, LaTeX with 1 ps figure embedded, using newpasp.sty (supplied). To appear in the proceedings of the XIXth IAP colloquium "Extrasolar Planets: Today and Tomorrow" held in Paris, France, 2003, June 30 -- July 4, ASP Conf. Se

the Psychology of Breakup Sex: Exploring the Motivational Factors and Affective Consequences of Post-breakup Sexual Activity

Popular culture has recently publicized a seemingly new postbreakup behavior called breakup sex. While the media expresses the benefits of participating in breakup sex, there is no research to support these claimed benefits. The current research was designed to begin to better understand this postbreakup behavior. In the first study, we examined how past breakup sex experiences made the individuals feel and how people predict they would feel in the future (n = 212). Results suggested that men are more likely than women to have felt better about themselves, while women tend to state they felt better about the relationship after breakup sex. The second study (n = 585) investigated why men and women engage in breakup sex. Results revealed that most breakup sex appears to be motivated by three factors: relationship maintenance, hedonism, and ambivalence. Men tended to support hedonistic and ambivalent reasons for having breakup sex more often than women. The two studies revealed that breakup sex may be differentially motivated (and may have different psychological consequences) for men and women and may not be as beneficial as the media suggests

On the role of buoyant flexure in glacier calving

Interactions between glaciers and the ocean are key for understanding the dynamics of the cryosphere in the climate system. Here we investigate the role of hydrostatic forces in glacier calving. We develop a mathematical model to account for the elastic deformation of glaciers in response to three effects: (i) marine and lake-terminating glaciers tend to enter water with a nonzero slope, resulting in upward flexure around the grounding line; (ii) horizontal pressure imbalances at the terminus are known to cause hydrostatic in-plane stresses and downward acting torque; (iii) submerged ice protrusions at the glacier front may induce additional buoyancy forces that can cause calving. Our model provides theoretical estimates of the importance of each effect and suggests geometric and material conditions under which a given glacier will calve from hydrostatic flexure. We find good agreement with observations. This work sheds light on the intricate processes involved in glacier calving and can be hoped to improve our ability to model and predict future changes in the ice-climate system

Accretion disk reversal and the spin-up/spin-down of accreting pulsars

We numerically investigate the hydrodynamics of accretion disk reversal and relate our findings to the observed spin-rate changes in the accreting X-ray pulsar GX~1+4. In this system, which accretes from a slow wind, the accretion disk contains two dynamically distinct regions. In the inner part viscous forces are dominant and disk evolution occurs on a viscous timescale. In the outer part dynamical mixing of material with opposite angular momentum is more important, and the externally imposed angular momentum reversal timescale governs the flow. In this outer region the disk is split into concentric rings of material with opposite senses of rotation that do not mix completely but instead remain distinct, with a clear gap between them. We thus predict that torque reversals resulting from accretion disk reversals will be accompanied by minima in accretion luminosity.Comment: 13 pages, 7 figures, accepted for publication in Ap

SPH Simulations of Accretion Disks and Narrow Rings

We model a massless viscous disk using Smoothed Particle Hydrodynamics (SPH) and note that it evolves according to the Lynden-Bell \& Pringle theory (1974) until a non-axisymmetric instability develops at the inner edge of the disk. This instability may have the same origin as the instability of initially axisymmetric viscous disks discussed by Lyubarskij et al. (1994). To clarify the evolution we evolved single and double rings of particles. It is actually inconsistent with the SPH scheme to set up a single ring as an initial condition because SPH assumes a smoothed initial state. As would be expected from an SPH simulation, the ring rapidly breaks up into a band. We analyse the stability of the ring and show that the predictions are confirmed by the simulation.Comment: 11 pages, uuencoded compressed postscript with 2 figs, accepted PASA. Also available at http://www.maths.monash.edu.au/~maddison/me/papers.htm