How Do We Come to Know? Exploring Maple Syrup Production and Climate Change in Near North Ontario

This paper reports on a pilot project exploring the impacts of climate change on maple syrup production in understudied near north, Ontario spaces. Maple syrup is produced by settler, Métis and First Nations communities for commercial distribution and as part of a mixed subsistence economy. The focus on maple syrup is opportune, since syrup production and sugar maple trees (Acer saccharum) are extremely susceptible to climate change and the biophysical and social impacts of climate change on maple syrup production in the near north of Ontario have yet to be understood. Given that the process of developing research is under-reported and that this project has had the opportunity to undertake a funded development process, this paper describes and assesses our process of ‘coming to know’, which has been guided by the following objectives: 1) to undertake an exploratory investigation of the nature of available data about long-term syrup production and climate change in both settler and Indigenous communities, 2) to include and valorize marginalized Indigenous voices and ecologies, 3) to focus on collecting climate change data from understudied near north spaces, 4) to assess the availability and quality of ecological and quantitative data in order to enhance locally-relevant understandings of climate change, and 5) to work towards the development of a cross-cultural and transdisciplinary methodological framework within which to accomplish the first four objectives. We approach these objectives across disciplinary boundaries and cultural perspectives, and with growing relationships with community partners. We describe the rich sources of information found through the pilot study and discuss highlights of our on-going process of developing our research project

Development of taxane resistance in a panel of human lung cancer cell lines

Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer. Unlike continuous or pulse exposure to high concentrations of chemotherapeutic drugs which yield high resistance and often cross resistance, most variants developed here displayed low level resistance to the selecting drug with slight cross-resistance. Pulsing with taxol resulted in more highly resistant clones (up to 51.4-fold). Analysis of taxol and taxotere in the four major lung cancer cell types showed the taxanes to be more effective against NSCLC (with the exception of SKMES-taxane selected variants) than against the SCLC. Comparison of taxol and taxotere shows that taxol induces higher levels of resistance than taxotere. Further, in taxotere-selected cell lines, the cells are more resistant to taxol than taxotere, suggesting that taxotere may be a superior taxane from a clinical view. Taxol treatment resulted in increased cross-resistance to 5-FU in all classes of lung cancer except DMS-53. The high levels of Pgp in the DMS-53 and selected variant suggests this mechanism is not related to Pgp expression. Analysis of the Pgp and MRP-1 status by combination inhibitory assays and Western blotting showed no consistent relationship between expression of the membrane pumps Pgp or MRP-1 and resistance. However, where high level resistance was seen, the parent cell line expressed Pgp or MRP-1 and was accompanied by increased levels in the variants. Overall we found that the clinically relevant models used here are useful for investigating mechanisms of taxane resistance

Early-Onset Familial Alzheimer Disease

An Alzheimer’s diagnosis is an overwhelming and devastating diagnosis for both patients and families. Now imagine if this diagnosis was made at age 55. Instead of looking forward to retirement and grandchildren, these people are preparing for a debilitating disease that will rob them of their memory, cognitive and functional abilities. Early-onset familial Alzheimer’s disease (EOFAD) affects people before the age of 65. Although extremely rare, some exhibit symptoms as early as in their 30s. One of the things most frustrating about this disease is so little is known about its cause. That and the fact there is no cure. There is research which demonstrates a connection between three gene mutations and the incidence of EOFAD. Knowledge of the potential cause behind their disease may help some patients and families better understand and cope with this disease

Panel: Peer-Based Faculty Evaluation v. Student Evaluation of Teaching

Maintaining peer-based faculty evaluation: a case study involving student surveys of teachin

Panel: Peer-Based Faculty Evaluation v. Student Evaluation of Teaching

Maintaining peer-based faculty evaluation: a case study involving student surveys of teachin

Panel: Peer-Based Faculty Evaluation v. Student Evaluation of Teaching

Maintaining peer-based faculty evaluation: a case study involving student surveys of teachin

Maintaining peer-based faculty evaluation: a case study involving student surveys of teaching

Bargaining regarding faculty evaluation is challenging in an environment in which administrators throughout higher education have successfully imposed corporate-style forms of evaluation and supervision that many have come to accept as normal, despite their incompatibility with principles of academic freedom and peer-review. Student surveys of teaching are increasingly central to this management strategy, despite the growing body of evidence indicating bias against historically marginalized groups in student survey results. This paper presents a case study of contract negotiations undertaken in 2016 at Dutchess Community College (SUNY) in Poughkeepsie, New York. During these negotiations the college administration sought to expand the use of “student evaluations of teaching” (SET) despite significant evidence that student feedback provides limited meaningful evaluative content concerning teaching and is shaped by gender, racial, and ethnic bias, as well as bias against academic rigor. We describe our effort to maintain a peer-based evaluation of student survey data, including the published research we used during negotiations and our experience with interest-based bargaining. We also analyze the strengths and weaknesses of our approach and results. These results include a successful effort to maintain the practice of limiting review of qualitative student feedback to peer-based review between faculty and department chairs within academic departments, although there was a limited but significant expansion of administrative oversight of some quantitative student survey data. Additionally, we were able to restrict the role of student feedback with contract language that limits the use of student survey results in faculty evaluation and requires that all consideration of these data be undertaken with evidence-based insight that student feedback is an important but limited vehicle for understanding the effectiveness of an individual’s teaching. Finally, an all-faculty committee of full-time and part-time faculty charged with evaluating the survey form and process was contractually established