Vague convergence of spectral shift functions for periodic restrictions of one-dimensional Schrodinger operators

We prove weak and vague convergence results for spectral shift functions associated with self-adjoint one-dimensional Schr\ odinger operators on intervals of the form $(-\ell,\ell)$ with periodic boundary conditions to the full-line spectral shift function in the infinite volume limit $\ell\to \infty$. The approach employed relies on the use of a Krein-type resolvent identity to relate the resolvent of the operator with periodic boundary conditions to the corresponding operator with Dirichlet boundary conditions in combination with various operator theoretic facts

A comparison of the UK Standard Assessment Procedure and detailed simulation of solar energy systems for dwellings

The drive to reduce worldwide Carbon Emissions directly associated with dwellings and to achieve a zero carbon home dictates that Renewable Energy Technologies will have an increasingly large role in the built environment. Created by the Building Research Establishment (BRE), the Standard Assessment Procedure (SAP) is the UK Government's approved methodology for assessing the energy ratings of dwellings. This paper presents an evaluation of the advantage given to SAP ratings by the domestic installation of typical Photovoltaic (PV) and Solar Domestic Hot Water (SDHW) systems in the UK. Comparable PV and SDHW systems will also be simulated with more detailed modelling packages. Results suggest that calculation variances can exist between the SAP methodology and detailed simulation methods, especially for higher performance systems that deviate from the default efficiency parameters

Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease.

A HUVEC cDNA library was screened with sera from two patients who had developed transplant-associated coronary artery disease (TxCAD) following cardiac transplantation. A total of six positive clones were isolated from a primary screen of 40 000 genes. Subsequent DNA sequence analysis identified these to be lysyl tRNA synthetase, ribosomal protein L7, ribosomal protein L9, beta transducin and TANK. Another gene whose product could not be identified showed homology to a human cDNA clone (DKFZp566M063) derived from fetal kidney. Full-length constructs of selected genes were expressed as his-tag recombinant fusion proteins and used to screen a wider patient base by ELISA to determine prevalence and association with TxCAD. Of these ribosomal protein L7 showed the highest prevalence (55.6%) with TxCAD sera compared to 10% non-CAD

Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9

OBJECTIVE: The Global FKRP Registry is a database for individuals with conditions caused by mutations in the Fukutin-Related Protein (FKRP) gene: limb girdle muscular dystrophy R9 (LGMDR9, formerly LGMD2I) and congenital muscular dystrophies MDC1C, Muscle-Eye-Brain Disease and Walker-Warburg Syndrome. The registry seeks to further understand the natural history and prevalence of FKRP-related conditions; aid the rapid identification of eligible patients for clinical studies; and provide a source of information to clinical and academic communities. METHODS: Registration is patient-initiated through a secure online portal. Data, reported by both patients and their clinicians, include: age of onset, presenting symptoms, family history, motor function and muscle strength, respiratory and cardiac function, medication, quality of life and pain. RESULTS: Of 663 registered participants, 305 were genetically confirmed LGMDR9 patients from 23 countries. A majority of LGMDR9 patients carried the common mutation c.826C \u3e A on one or both alleles; 67.9% were homozygous and 28.5% were compound heterozygous for this mutation. The mean ages of symptom onset and disease diagnosis were higher in individuals homozygous for c.826C \u3e A compared with individuals heterozygous for c.826C \u3e A. This divergence was replicated in ages of loss of running ability, wheelchair-dependence and ventilation assistance; consistent with the milder phenotype associated with individuals homozygous for c.826C \u3e A. In LGMDR9 patients, 75.1% were currently ambulant and 24.6%, nonambulant (unreported in 0.3%). Cardiac impairment was reported in 23.2% (30/129). INTERPRETATION: The Global FKRP Registry enables the collection of patient natural history data, which informs academics, healthcare professionals and industry. It represents a trial-ready cohort of individuals and is centrally placed to facilitate recruitment to clinical studies

Ultrafast multireflector physical-optics beam simulations for the HFI instrument on the ESA PLANCK Surveyor

We present the latest results of our fast physical optics simulations of the ESA PLANCK HFI beams. The main beams of both polarized and non-polarized channels have been computed with account of broad frequency bands for the final design and positions of the HFI horns. Gaussian fitting parameters of the broadband beams have been presented. Beam polarization characteristics and horn defocusing effects have been studied.Comment: 8 pages, 4 figure