Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.Peer reviewedPublisher PD

A Generative-Discriminative Basis Learning Framework to Predict Clinical Severity from Resting State Functional MRI Data

We propose a matrix factorization technique that decomposes the resting state fMRI (rs-fMRI) correlation matrices for a patient population into a sparse set of representative subnetworks, as modeled by rank one outer products. The subnetworks are combined using patient specific non-negative coefficients; these coefficients are also used to model, and subsequently predict the clinical severity of a given patient via a linear regression. Our generative-discriminative framework is able to exploit the structure of rs-fMRI correlation matrices to capture group level effects, while simultaneously accounting for patient variability. We employ ten fold cross validation to demonstrate the predictive power of our model on a cohort of fifty eight patients diagnosed with Autism Spectrum Disorder. Our method outperforms classical semi-supervised frameworks, which perform dimensionality reduction on the correlation features followed by non-linear regression to predict the clinical scores

High-resolution absorption spectroscopy of the circumgalactic medium of the Milky Way

In this article we discuss the importance of high-resolution absorption spectroscopy for our understanding of the distribution and physical nature of the gaseous circumgalactic medium (CGM) that surrounds the Milky Way. Observational and theoretical studies indicate a high complexity of the gas kinematics and an extreme multi-phase nature of the CGM in low-redshift galaxies. High-precision absorption-line measurements of the Milky Way's gas environment thus are essential to explore fundamental parameters of circumgalactic gas in the local Universe, such as mass, chemical composition, and spatial distribution. We shortly review important characteristics of the Milky Way's CGM and discuss recent results from our multi-wavelength observations of the Magellanic Stream. Finally, we discuss the potential of studying the warm-hot phase of the Milky Way's CGM by searching for extremely weak [FeX] l6374.5 and [FeIVX] l5302.9 absorption in optical QSO spectra.Comment: 7 pages, 4 figures; accepted for publication in Astronomical Notes (paper version of a talk presented at the 10th Thinkshop, Potsdam, 2013

Fractional Exclusion Statistics for the Multicomponent Sutherland Model

We show by microscopic calculation that thermodynamics of the multicomponent Sutherland model is equivalent to that of a free particle system with fractional exclusion statistics at all temperatures. The parameters for exclusion statistics are given by the strength of the repulsive interaction, and have both intra- and inter-species components. We also show that low temperature properties of the system are described in terms of free fractional particles without the statistical parameters for different species. The effective exclusion statistics for intra-species at low temperatures depend on polarization of the system.Comment: 13 pages, using RevTex, 5 figures on reques

The kaon semileptonic form factor in Nf=2+1 domain wall lattice QCD with physical light quark masses

We present the first calculation of the kaon semileptonic form factor with sea and valence quark masses tuned to their physical values in the continuum limit of 2+1 flavour domain wall lattice QCD. We analyse a comprehensive set of simulations at the phenomenologically convenient point of zero momentum transfer in large physical volumes and for two different values of the lattice spacing. Our prediction for the form factor is f+(0)=0.9685(34)(14) where the first error is statistical and the second error systematic. This result can be combined with experimental measurements of K->pi decays for a determination of the CKM-matrix element for which we predict |Vus|=0.2233(5)(9) where the first error is from experiment and the second error from the lattice computation.Comment: 21 pages, 7 figures, 6 table