Essential Oils from Apple mint (Mentha suaveolens) and Passionflower fruit (Passiflora incarnata): Studies on Cognition, Coordination, and Chemical Components.

Plant essential oils (EO) are used as perfumes, lotions and air fresheners because of their pleasant aromas, but EO also have the ability to elicit changes in mood and behavior. These activities are influenced by the mode of administration and by multiple signaling pathways. The EO aromas from organically grown apple mint (Mentha suaveolens) and passionflower fruit (Passiflora incarnata) were assessed for their effects on cognition and coordination. Participants completed two tasks designed to test working memory and bimanual task efficiency in rooms infused with apple mint, passionflower fruit or control EO. Bimanual coordination was assessed using the Intercept2 program and the Memory Span component of CogLab 2.0 was utilized as a test of working memory. Then, the EO were analyzed by GC-MS, resulting in the identification of several compounds with affinity towards olfactory receptors and neurotransmitter systems. For specific memory subtests within CogLab, EO from apple mint aided number recall, whereas passionflower fruit hindered recall of numbers and letters that sound similar. Passionflower fruit EO slightly enhanced bimanual task coordination. The results indicate that specific aromas may differentially affect task performance

Electrophysiological and Imaging Calcium Biomarkers of Aging in Male and Female 5×FAD Mice

BACKGROUND: In animal models and tissue preparations, calcium dyshomeostasis is a biomarker of aging and Alzheimer\u27s disease that is associated with synaptic dysfunction, neuritic pruning, and dysregulated cellular processes. It is unclear, however, whether the onset of calcium dysregulation precedes, is concurrent with, or is the product of pathological cellular events (e.g., oxidation, amyloid-β production, and neuroinflammation). Further, neuronal calcium dysregulation is not always present in animal models of amyloidogenesis, questioning its reliability as a disease biomarker. OBJECTIVE: Here, we directly tested for the presence of calcium dysregulation in dorsal hippocampal neurons in male and female 5×FAD mice on a C57BL/6 genetic background using sharp electrodes coupled with Oregon-green Bapta-1 imaging. We focused on three ages that coincide with the course of amyloid deposition: 1.5, 4, and 10 months old. METHODS: Outcome variables included measures of the afterhyperpolarization, short-term synaptic plasticity, and calcium kinetics during synaptic activation. Quantitative analyses of spatial learning and memory were also conducted using the Morris water maze. Main effects of sex, age, and genotype were identified on measures of electrophysiology and calcium imaging. RESULTS: Measures of resting Oregon-green Bapta-1 fluorescence showed significant reductions in the 5×FAD group compared to controls. Deficits in spatial memory, along with increases in Aβ load, were detectable at older ages, allowing us to test for temporal associations with the onset of calcium dysregulation. CONCLUSION: Our results provide evidence that reduced, rather than elevated, neuronal calcium is identified in this 5×FAD model and suggests that this surprising result may be a novel biomarker of AD

Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD10

Social science for conservation in working landscapes and seascapes

Biodiversity is in precipitous decline globally across both terrestrial and marine environments. Therefore, conservation actions are needed everywhere on Earth, including in the biodiversity rich landscapes and seascapes where people live and work that cover much of the planet. Integrative landscape and seascape approaches to conservation fill this niche. Making evidence-informed conservation decisions within these populated and working landscapes and seascapes requires an in-depth and nuanced understanding of the human dimensions through application of the conservation social sciences. Yet, there has been no comprehensive exploration of potential conservation social science contributions to working landscape and seascape initiatives. We use the Smithsonian Working Land and Seascapes initiative – an established program with a network of 14 sites around the world – as a case study to examine what human dimensions topics are key to improving our understanding and how this knowledge can inform conservation in working landscapes and seascapes. This exploratory study identifies 38 topics and linked questions related to how insights from place-based and problem-focused social science might inform the planning, doing, and learning phases of conservation decision-making and adaptive management. Results also show how conservation social science might yield synthetic and theoretical insights that are more broadly applicable. We contend that incorporating insights regarding the human dimensions into integrated conservation initiatives across working landscapes and seascapes will produce more effective, equitable, appropriate and robust conservation actions. Thus, we encourage governments and organizations working on conservation initiatives in working landscapes and seascapes to increase engagement with and funding of conservation social science

Skunk River Review January 1992, vol 3

https://openspace.dmacc.edu/skunkriver/1006/thumbnail.jp