The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC

Although loss of the inhibitor of apoptosis (LAP) protein DIAP1 has been shown to result in caspase activation and spontaneous cell death in Drosophila cells and embryos, the point at which DIAP1 normally functions to inhibit caspase activation is unknown. Depletion of the DIAP1 protein in Drosophila S2 cells or the Sf-IAP protein in Spodoptera frugiperda Sf21 cells by RNA interference (RNAi) or cycloheximide treatment resulted in rapid and widespread caspase-dependent apoptosis. Co-silencing of dronc or dark largely suppressed this apoptosis, indicating that DIAP1 is normally required to inhibit an activity dependent on these proteins. Silencing of dronc also inhibited DRICE processing following stimulation of apoptosis, demonstrating that DRONC functions as an apical caspase in S2 cells. Silencing of diap1 or treatment with UV light induced DRONC processing, which occurred in two steps. The first step appeared to occur continuously even in the absence of an apoptotic signal and to be dependent on DARK because full-length DRONC accumulated when dark was silenced in non-apoptotic cells. In addition, treatment with the proteasome inhibitor MG132 resulted in accumulation of this initially processed form of DRONC, but not full-length DRONC, in non-apoptotic cells. The second step in DRONC processing was observed only in apoptotic cells. These results indicate that the initial step in DRONC processing occurs continuously via a DARK-dependent mechanism in Drosophila cells and that DIAP1 is required to prevent excess accumulation of this first form of processed DRONC, presumably through its ability to act as a ubiquitin-protein ligase

Deciding on an Efficient Involuntary Bankruptcy Filing Petition Rule

Bankruptcy law deals with last recourse solutions to extreme financial and balance-sheet problems. Both debtor and his creditors will have incentives to begin an insolvency case balanced with other reasons that will encourage them not to begin it. Consequently legal systems usually tend to concentrate on rules that will spur either group to bring the bankruptcy proceeding when it is adequate. As a result some countries have creditors bringing most of the proceedings (as is the case of the United Kingdom) and others have debtors as the prime figures. This paper focuses on the creditor side of the equation and aims to provide for a normative stance on whether bankruptcy laws should promote liberal or restrictive standards for creditors to comply with in order to file an involuntary bankruptcy petition. Specifically, this paper will deal with the “unpaid due obligation” standard, which implies that a creditor can file an involuntary petition on the mere grounds of having an unpaid debt owed to the creditor. I will argue that a rule which restricts the ability of creditors to file an involuntary bankruptcy petition is inefficient

Lender Control Liability Functional Examination: The Firm and Heuristics

Lender control is criticized due to problems arising out of conflict of interests among different priority claimholders. Recently, it has been defended as a way to make the reorganization process more efficient. This paper builds on previous research on the theory of the firm to show that lender control generates inefficiencies even in situations where there is only one layer of legal claimants. Specifically, the paper demonstrates that departing from the nexus of explicit contracts paradigm, used by both previous critics and supporters of lender control, allows to understand other sources of lender control inefficiencies based on its inability to incorporate full firm value into her decision making. The paper suggests that, in contrast to the dwarfed role courts give lender control liability, its proper function should be to reestablish efficient incentives for a controlling lender. Lastly, drawing from the behavioral law and economics literature, the paper shows that hindsight bias is not the only cognitive error distorting adjudications of lender control liability and due attention should be given to anchoring in damage assessments

Deciding on an Efficient Involuntary Bankruptcy Filing Petition Rule

Bankruptcy law deals with last recourse solutions to extreme financial and balance-sheet problems. Both debtor and his creditors will have incentives to begin an insolvency case balanced with other reasons that will encourage them not to begin it. Consequently legal systems usually tend to concentrate on rules that will spur either group to bring the bankruptcy proceeding when it is adequate. As a result some countries have creditors bringing most of the proceedings (as is the case of the United Kingdom) and others have debtors as the prime figures. This paper focuses on the creditor side of the equation and aims to provide for a normative stance on whether bankruptcy laws should promote liberal or restrictive standards for creditors to comply with in order to file an involuntary bankruptcy petition. Specifically, this paper will deal with the “unpaid due obligation” standard, which implies that a creditor can file an involuntary petition on the mere grounds of having an unpaid debt owed to the creditor. I will argue that a rule which restricts the ability of creditors to file an involuntary bankruptcy petition is inefficient

Pillars Of Prosperity: Leveraging Regional Assets To Grow Minnesota's Economy

Minnesota has always been rich with assets -- a skilled labor force, good jobs in diverse industries, globally competitive companies, and abundant lakes and parks that provide a high quality of life for the people who call it home.However, to maintain its strong economy and quality of life, Minnesota must adapt to fast-changing trends in the global economy, trends that affect each of the state's regions and communities differently.This report explores how the state of Minnesota -- the governor's administration together with the Minnesota Legislature -- can partner with regional networks to foster economic growth and extend prosperity to greater numbers of Minnesotans

Deciding on an Efficient Involuntary Bankruptcy Filing Petition Rule

Bankruptcy law deals with last recourse solutions to extreme financial and balance-sheet problems. Both debtor and his creditors will have incentives to begin an insolvency case balanced with other reasons that will encourage them not to begin it. Consequently legal systems usually tend to concentrate on rules that will spur either group to bring the bankruptcy proceeding when it is adequate. As a result some countries have creditors bringing most of the proceedings (as is the case of the United Kingdom) and others have debtors as the prime figures. This paper focuses on the creditor side of the equation and aims to provide for a normative stance on whether bankruptcy laws should promote liberal or restrictive standards for creditors to comply with in order to file an involuntary bankruptcy petition. Specifically, this paper will deal with the “unpaid due obligation” standard, which implies that a creditor can file an involuntary petition on the mere grounds of having an unpaid debt owed to the creditor. I will argue that a rule which restricts the ability of creditors to file an involuntary bankruptcy petition is inefficient

Synchronization in interacting Scale Free Networks

We study the fluctuations of the interface, in the steady state, of the Surface Relaxation Model (SRM) in two scale free interacting networks where a fraction $q$ of nodes in both networks interact one to one through external connections. We find that as $q$ increases the fluctuations on both networks decrease and thus the synchronization reaches an improvement of nearly $40\%$ when $q=1$. The decrease of the fluctuations on both networks is due mainly to the diffusion through external connections which allows to reducing the load in nodes by sending their excess mostly to low-degree nodes, which we report have the lowest heights. This effect enhances the matching of the heights of low-and high-degree nodes as $q$ increases reducing the fluctuations. This effect is almost independent of the degree distribution of the networks which means that the interconnection governs the behavior of the process over its topology.Comment: 13 pages, 7 figures. Added a relevant reference.Typos fixe

Cracking the Code on Stem: A People Strategy for Nevada\u27s Economy

Nevada has in place a plausible economic diversification strategy—and it’s beginning to work. Now, the state and its regions need to craft a people strategy. Specifically, the state needs to boost the number of Nevadans who possess at least some postsecondary training in the fields of science, technology, engineering, or math—the so-called “STEM” disciplines (to which some leaders add arts and design to make it “STEAM”). The moment is urgent—and only heightened by the projected worker needs of Tesla Motors’ planned “gigafactory” for lithium-ion batteries in Storey County. Even before the recent Tesla commitment, a number of the more high-tech industry sectors targeted by the state’s new economic diversification strategy had begun to deliver significant growth. Most notable in fast-growing sectors like Business IT Ecosystems (as defined by the Governor’s Office for Economic Development) and large sectors like Health and Medical Services, this growth has begun to increase the demand in Nevada for workers with at least a modicum of postsecondary training in one or more STE M discipline. However, there is a problem. Even though many available opportunities require no more than the right community college certificate, insufficient numbers of Nevadans have pursued even a little STEM training. As a result, too few Nevadans are ready to participate in the state’s emerging STEM economy. The upshot: Without concerted action to prepare more Nevadans for jobs in STEM-intensive fields, skills shortages could limit growth in the state’s most promising target industries and Nevadans could miss out on employment that offers superior paths to opportunity and advancement. Which is the challenge this report addresses: Aimed at focusing the state at a critical moment, this analysis speaks to Nevada’s STEM challenge by providing a new assessment of Nevada’s STEM economy and labor market as well as a review of actions that leaders throughout the state—whether in the public, private, civic, or philanthropic sectors—can take to develop a workforce capable of supporting continued growth through economic diversification