Correlations with proliferation status of tumours. a.

<p>Box plot corresponding to p53 mRNA expression depending on proliferation status. <b>b.</b> Box plot corresponding to proliferation rate depending on <i>TP53</i> mutation status. <b>c.</b> Box plot corresponding to proliferation rate depending on TP53 mutation status coupled with level of p53 mRNA expression. <b>d.</b> Box plot corresponding to proliferation rate depending on <i>LOH</i> in 17p13. <b>e.</b> Box plot corresponding to p53 mRNA expression depending on <i>TP53</i> mutation status. <b>f.</b> Box plot corresponding to p53 mRNA expression depending on <i>LOH</i> in 17p13. <i>p</i><0.05 was considered significant.</p

Schematic representation of P53 protein.

<p>Its 3 domains and corresponding coding exons are represented. Mutations of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055103#pone-0055103-t002" target="_blank">Table 2</a> appear at the top of coding exons.</p

Detail of observed <i>TP53</i> gene mutations.

<p>Detail of observed <i>TP53</i> gene mutations.</p

Influence of <i>TP53</i> mutations on outcomes. a.

<p>Kaplan-Meier curves of disease-free (left) and overall (right) survival in patients categorized on different categories of p53 mRNA expression. <b>b.</b> Kaplan-Meier curves of disease-free (left) and overall (right) survival in patients categorized on different categories of LOH in 17p13. <b>c.</b> Kaplan-Meier curves of disease-free (left) and overall (right) survival in patients categorized on <i>TP53</i> gene mutation status. Dotted red lines correspond to median disease-free or overall survival. <b>d.</b> Kaplan-Meier curves of disease-free (left) and overall (right) survival in patients categorized on different kinds and location of <i>TP53</i> mutation. Dotted red lines correspond to median disease-free or overall survival. <i>p</i>-values were calculated in relation to wild-type population (green: <i>vs.</i> missense mutation in the 2^nd domain, blue: <i>vs.</i> missense mutation in the 3^rd domain; red: <i>vs.</i> mutation inducing a loss of the 2^nd and 3^rd domains). Censored patients are represented on the curves by black crosses. Number at risk are presented below graphs. Only <i>p</i><0.05 was considered significant.</p

Clinical details of studied population.

<p>NA: Not Available.</p