1,639 research outputs found
CHARACTERISTICS AND RESIDENTIAL PATTERNS OF ENERGY-RELATED WORK FORCES IN THE NORTHERN GREAT PLAINS
The socioeconomic characteristics of construction and operating work forces at energy related facilities in the Northern Great Plains were analyzed. A primary interest was to explain differences in local hire rates and settlement patterns on the basis of characteristics of the project and site area. In general, it was found that local hire rates for operating workers can be expected to be substantially greater than for construction workers when differences in project and site characteristics are taken into account. Nonlocal construction workers were found to live in larger communities and to commute substantially greater distances to the project site than nonlocal operating workers.Labor and Human Capital,
Evolutionary Dynamics While Trapped in Resonance: A Keplerian Binary System Perturbed by Gravitational Radiation
The method of averaging is used to investigate the phenomenon of capture into
resonance for a model that describes a Keplerian binary system influenced by
radiation damping and external normally incident periodic gravitational
radiation. The dynamical evolution of the binary orbit while trapped in
resonance is elucidated using the second order partially averaged system. This
method provides a theoretical framework that can be used to explain the main
evolutionary dynamics of a physical system that has been trapped in resonance.Comment: REVTEX Style, Submitte
Innovations in conditioning and post-transplant maintenance in AML: genomically informed revelations on the graft-versus-leukemia effect
Acute Myeloid Leukemia (AML) is the prototype of cancer genomics as it was the first published cancer genome. Large-scale next generation/massively parallel sequencing efforts have identified recurrent alterations that inform prognosis and have guided the development of targeted therapies. Despite changes in the frontline and relapsed standard of care stemming from the success of small molecules targeting FLT3, IDH1/2, and apoptotic pathways, allogeneic stem cell transplantation (alloHSCT) and the resulting graft-versus-leukemia (GVL) effect remains the only curative path for most patients. Advances in conditioning regimens, graft-vs-host disease prophylaxis, anti-infective agents, and supportive care have made this modality feasible, reducing transplant related mortality even among patients with advanced age or medical comorbidities. As such, relapse has emerged now as the most common cause of transplant failure. Relapse may occur after alloHSCT because residual disease clones persist after transplant, and develop immune escape from GVL, or such clones may proliferate rapidly early after alloHSCT, and outpace donor immune reconstitution, leading to relapse before any GVL effect could set in. To address this issue, genomically informed therapies are increasingly being incorporated into pre-transplant conditioning, or as post-transplant maintenance or pre-emptive therapy in the setting of mixed/falling donor chimerism or persistent detectable measurable residual disease (MRD). There is an urgent need to better understand how these emerging therapies modulate the two sides of the GVHD vs. GVL coin: 1) how molecularly or immunologically targeted therapies affect engraftment, GVHD potential, and function of the donor graft and 2) how these therapies affect the immunogenicity and sensitivity of leukemic clones to the GVL effect. By maximizing the synergistic action of molecularly targeted agents, immunomodulating agents, conventional chemotherapy, and the GVL effect, there is hope for improving outcomes for patients with this often-devastating disease
Geometrical Models of the Phase Space Structures Governing Reaction Dynamics
Hamiltonian dynamical systems possessing equilibria of stability type display \emph{reaction-type
dynamics} for energies close to the energy of such equilibria; entrance and
exit from certain regions of the phase space is only possible via narrow
\emph{bottlenecks} created by the influence of the equilibrium points. In this
paper we provide a thorough pedagogical description of the phase space
structures that are responsible for controlling transport in these problems. Of
central importance is the existence of a \emph{Normally Hyperbolic Invariant
Manifold (NHIM)}, whose \emph{stable and unstable manifolds} have sufficient
dimensionality to act as separatrices, partitioning energy surfaces into
regions of qualitatively distinct behavior. This NHIM forms the natural
(dynamical) equator of a (spherical) \emph{dividing surface} which locally
divides an energy surface into two components (`reactants' and `products'), one
on either side of the bottleneck. This dividing surface has all the desired
properties sought for in \emph{transition state theory} where reaction rates
are computed from the flux through a dividing surface. In fact, the dividing
surface that we construct is crossed exactly once by reactive trajectories, and
not crossed by nonreactive trajectories, and related to these properties,
minimizes the flux upon variation of the dividing surface.
We discuss three presentations of the energy surface and the phase space
structures contained in it for 2-degree-of-freedom (DoF) systems in the
threedimensional space , and two schematic models which capture many of
the essential features of the dynamics for -DoF systems. In addition, we
elucidate the structure of the NHIM.Comment: 44 pages, 38 figures, PDFLaTe
Breakdown of Conformal Invariance at Strongly Random Critical Points
We consider the breakdown of conformal and scale invariance in random systems
with strongly random critical points. Extending previous results on
one-dimensional systems, we provide an example of a three-dimensional system
which has a strongly random critical point. The average correlation functions
of this system demonstrate a breakdown of conformal invariance, while the
typical correlation functions demonstrate a breakdown of scale invariance. The
breakdown of conformal invariance is due to the vanishing of the correlation
functions at the infinite disorder fixed point, causing the critical
correlation functions to be controlled by a dangerously irrelevant operator
describing the approach to the fixed point. We relate the computation of
average correlation functions to a problem of persistence in the RG flow.Comment: 9 page
Structural Susceptibility and Separation of Time Scales in the van der Pol Oscillator
We use an extension of the van der Pol oscillator as an example of a system
with multiple time scales to study the susceptibility of its trajectory to
polynomial perturbations in the dynamics. A striking feature of many nonlinear,
multi-parameter models is an apparently inherent insensitivity to large
magnitude variations in certain linear combinations of parameters. This
phenomenon of "sloppiness" is quantified by calculating the eigenvalues of the
Hessian matrix of the least-squares cost function which typically span many
orders of magnitude. The van der Pol system is no exception: Perturbations in
its dynamics show that most directions in parameter space weakly affect the
limit cycle, whereas only a few directions are stiff. With this study we show
that separating the time scales in the van der Pol system leads to a further
separation of eigenvalues. Parameter combinations which perturb the slow
manifold are stiffer and those which solely affect the transients in the
dynamics are sloppier.Comment: 7 pages, 4 figure
Role of heavy-meson exchange in pion production near threshold
Recent calculations of -wave pion production have severely underestimated
the accurately known \ total cross section near
threshold. In these calculations, only the single-nucleon axial-charge operator
is considered. We have calculated, in addition to the one-body term, the
two-body contributions to this reaction that arise from the exchange of mesons.
We find that the inclusion of the scalar -meson exchange current (and
lesser contributions from other mesons) increases the cross section by about a
factor of five, and leads to excellent agreement with the data. The results are
neither very sensitive to changes in the distorting potential that generates
the wave function, nor to different choices for the meson-nucleon form
factors. We argue that \ data provide direct
experimental evidence for meson-exchange contributions to the axial current.Comment: 28 Pages, IU-NTC #93-0
Wigner's Dynamical Transition State Theory in Phase Space: Classical and Quantum
A quantum version of transition state theory based on a quantum normal form
(QNF) expansion about a saddle-centre-...-centre equilibrium point is
presented. A general algorithm is provided which allows one to explictly
compute QNF to any desired order. This leads to an efficient procedure to
compute quantum reaction rates and the associated Gamov-Siegert resonances. In
the classical limit the QNF reduces to the classical normal form which leads to
the recently developed phase space realisation of Wigner's transition state
theory. It is shown that the phase space structures that govern the classical
reaction d ynamicsform a skeleton for the quantum scattering and resonance
wavefunctions which can also be computed from the QNF. Several examples are
worked out explicitly to illustrate the efficiency of the procedure presented.Comment: 132 pages, 31 figures, corrected version, Nonlinearity, 21 (2008)
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