5 research outputs found
Comparison of different types of twin pregnancies in terms of obstetric and perinatal outcomes: association of vanished twins with methylenetetrahydrofolate reductase (MTHFR) polymorphism(s).
Vanished twin (VT) has been associated with poor perinatal outcomes. Our research aimed to investigate the outcomes of pregnancies with vanished twin and its possible association with methylenetetrahydrofolate reductase (MTHFR) polymorphisms
Comparison of different types of twin pregnancies in terms of obstetric and perinatal outcomes: association of vanished twins with methylenetetrahydrofolate reductase (MTHFR) polymorphism(s)
PurposeVanished twin (VT) has been associated with poor perinatal
outcomes. Our research aimed to investigate the outcomes of pregnancies
with vanished twin and its possible association with
methylenetetrahydrofolate reductase (MTHFR) polymorphisms.MethodsThis
study consisted of 30 of 38 VT pregnancies (group 1, VT group), 109
singletons (group 2), 70 spontaneous twins (group 3), and 101 in vitro
fertilization (IVF)/intracytoplasmic sperm injection (ICSI) twins (group
4).ResultsMost patients in group 1 (28/30) were tested for MTHFR genes
(C677T or A1298C polymorphisms). Eight of the 38 pregnancies with VT
(21.1\%) resulted in miscarriage. The prevalence of 2 or more pregnancy
losses in the obstetric history in group 1 was higher (23.3\%) than
those in the other groups (p=0.007, (2)=17.8). The allelic frequencies
of MTHFR 677 and MTHFR 1298 in group 1 were 0.268 and 0.429,
respectively (higher than those in healthy population). The median
birthweights in groups 1, 2, 3, and 4 were 2940, 3200, 2300, and 2095g,
respectively. The prevalence of respiratory distress syndrome was
significantly higher in the IVF/ICSI twin pregnancy group (p<0.001,
(2)=21.2). Early pregnancy loss and the presence of 2 or more
miscarriages in the obstetric history of pregnancies with VT were more
frequent.ConclusionThe coincidence of VT and MTHFR polymorphisms might
play an incidental or factual role in this connection