Experiment Design.

<p>Definition of abbreviations: J = TMC 207, R = Rifampin, M = Moxifloxacin, H = Isoniazid, Z = Pyrazinamide, A = amikacin, Et = ethionamide.</p><p>Mice were infected intravenously with 1.1×10⁶ of <i>M. tuberculosis</i> H37Rv.</p><p>Day -18: the day after infection, Day 0: start of treatment.</p><p>*Mice kept untreated for mortality assessment.</p><p>All drugs were given 5 times per week at the following doses: J, 25 mg/kg; R, 10 mg/kg; M, 100 mg/kg; H, 25 mg/kg; Z, 150 mg/kg; A, 150 mg/kg; Et, 50 mg/kg.</p

Proportion of mice with positive culture of lung 3 months after treatment completion (relapse).^*

<p>*Lung CFU count at start of treatment (D0): 7.1 log10 CFU.</p><p>Definition of abbreviations: J = TMC 207, R = Rifampin, M = Moxifloxacin, H = Isoniazid, Z = Pyrazinamide, A = amikacin, Et = ethionamide.</p>a<p>significantly more relapses than RHZ (p<0.05).</p>b<p>not significantly different from RHZ (p>0.05).</p