35 research outputs found
Incidence and Cost of Rotavirus Hospitalizations in Denmark
Two models provide reliable estimates that can be used to assess vaccine need and effectiveness
Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis.
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This article is open access.We conducted a genome-wide association scan (GWAS) of endometriosis using 25.5 million sequence variants detected through whole-genome sequencing (WGS) of 8,453 Icelanders and imputed into 1,840 cases and 129,016 control women, followed by testing of associated variants in Danish samples. Here we report the discovery of a new endometriosis susceptibility locus on 4q12 (rs17773813[G], OR=1.28; P=3.8 × 10(-11)), upstream of KDR encoding vascular endothelial growth factor receptor 2 (VEGFR2). The variant correlates with disease severity (P=0.0046) when moderate/severe endometriosis cases are tested against minimal/mild cases. We further report association of rs519664[T] in TTC39B on 9p22 with endometriosis (P=4.8 × 10(-10); OR=1.29). The involvement of KDR in endometriosis risk highlights the importance of the VEGF pathway in the pathogenesis of the disease.e Danish
National Research Foundation. Additional support for the DNBC has been obtained
from the Danish Pharmacists’ Fund, the Egmont Foundation, the March of Dimes Birth
Defects Foundation, the Augustinus Foundation and the Health Fund of the Danish
Health Insurance Societies. B.F. is supported by an Oak Foundation fellowshi