The Youth Transitions Study: Final Report - Summary of Key Findings

falsePalmerstnon Nort

The Youth Transitions Study: Final Report

falsePalmerson Nort

Lipopolysaccharide-specific acyloxyacyl hydrolase

" An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids from their ester linkages to hydroxy groups of 3-hydroxyfatty acids, the latter being being bound in turn to lipopolysaccharide glycosaminyl residues. The hydrolyzed fatty acids may include dodecanoic acid, tetradecanoic acid and hexadecanoic acid. This enzyme showed a molecular weight by gel exclusion chromatography between about 50,000 Daltons and about 70,000 Daltons, and a molecular weight by polyacrylamide gel electrophoresis with sodium dodecylsulphate, using reduced molecular weight standards, of approximately 54,000 to 60,000 Daltons. Altered bacterial lipopolysaccharide substantially without fatty acids bound in ester linkage to hydroxy groups of 3-hydroxyfatty acids covalently linked to a glucosaminyl moiety of lipopolysaccharide lipid A are produced. Since the structure of the lipid A moiety is highly conserved, acyloxyacyl hydrolase may act on lipopolysaccharide of many different pathogenic bacteria (for example Salmonella, Escherichia, Hemophilus, and Neisseria). Such altered bacterial lipopolysaccharide, having toxicity reduced more than immunostimulatory activity, may be therapeutically useful: (1) as vaccines to prevent Gram-negative bacterial diseases by inducing antibodies to lipopolysaccharide O-polysaccharide or R-core antigens, (2) as antidotes to treat or prevent Gram-negative bacterial sepsis (""septic shock""), or (3) as adjuvants to enhance formation of antibodies to other antigens. the acyloxyacyl hydrolase itself may be prophylactically or therapeutically useful to detoxify endogenous lipopolysaccharide in patients with Gram-negative bacterial diseases. The enzyme may also be used to remove toxic lipopolysaccharide from therapeutic injectants. "Board of Regents, University of Texas Syste

Laser measuring system for incremental assemblies

Wire-wrapped frame assemblies used in spark chambers and the like can be measured using a system which utilizes a laser, an interferometer, and a retroreflector to precisely measure distance. A light source and a photodetector are located adjacent the incremental assembly and mounted on a movable carriage. The interferometer is also mounted on the movable carriage, while the laser and retroreflector are positioned at either end of the carriage track. The carriage is moved along one edge of the incremental assembly between the retroreflector and the laser, and as the carriage is moved, the light from the light source to the photodetector is interrupted. This produces a trigger command to a control unit which in turn causes a distance measurement to be made. A printout is provided for each sampling trigger command to list such items as ideal position, actual position and amount of error

Apollo experience report: Command and service module electrical power distribution on subsystem

A review of the design philosophy and development of the Apollo command and service modules electrical power distribution subsystem, a brief history of the evolution of the total system, and some of the more significant components within the system are discussed. The electrical power distribution primarily consisted of individual control units, interconnecting units, and associated protective devices. Because each unit within the system operated more or less independently of other units, the discussion of the subsystem proceeds generally in descending order of complexity; the discussion begins with the total system, progresses to the individual units of the system, and concludes with the components within the units

GSFC Venus atmosphere simulator

The design and preliminary testing of a Venus Atmosphere Simulation System are described. The system was designed for testing a quadrupole mass spectrometer proposed for the Pioneer-Venus Experiment. The system is capable of providing programmed temperature cycles up to 550 C, and manually controlled pressure up to 100 atmospheres

Laser measuring system for wire-wrapped frame assemblies

The laser measuring system is designed to automatically measure and record the distances between small diameter wires on a wire wrapped grid frame assembly to an accuracy of 0.00635 mm (0.00025 in.). The system utilizes a helium-neon gas laser beam as the measuring instrument with a remote interferometer and retroreflector, a light source and photodetector to detect the wire positions, in conjunction with recording, display and printout units. The laser measuring system is utilized to perform precise automatic measurements for wire application machines or as an automatic feedback device for positioning wires and/or to adjust them for out of tolerance conditions

03-21-1979 Clerk Memo

Both the CAS\u27s judgment and the complaint, App. 3a, 5a, list Leila G. Brown, et at., as plaintiffs, and Robert R. Williams, et al., as defendants. Therefore a vote to affirm is a vote to uphold the finding of dilution and in favor of the plaintiffs

Evaluation of meta-benzenedisulfonic acid as a stress-reducing additive in a Watts nickel electroplating bath

Internal stress and deposit hardness of nickel electrodeposited containing controlled quantities of meta-benzenedisulfonic aci