28 research outputs found
Adaptive Reuse through Layering: Transforming the Rex Trueform Clothing Factory
The announcement in March 2005 of the imminent closure of the Rex Trueformclothing manufacturing plant in Salt River created a large impact on the CapeTown economy in view of the nearly 1000 jobs that were at risk. The reason forthe closure, according to management, was due to globalisation.1Four years have past since the last garment was produced in this factorybuilding, which was designed in 1934 by one of Cape Town's best-knownmodernist architects, Max Policansky. It is now abandoned and derelict -left fordead with the possibility of demolition threatening its existence.This thesis will focus on the adaptive reuse of the Rex Trueform ClothingFactory in Salt River. I am proposing to transform the Rex Trueform Factory intoa Skills Training- & Workshop Facility for the Cape Town Garment Industry. Thisnew facility will provide learning spaces for the training of those working in thegarment and textile industry, as well as offer a creative workshop environmentfor small clothing manufacturing enterprises. In addition, residential and retailspaces will be provided, as well as a clothing market.This project will also demonstrate how the layering of architectural modes ofexpression can produce delightful and surprising results. As cities constantlyevolve through dramatic change brought by large-scale new-built redevelopments,less obvious change occur as existing buildings undergo a morestable, continual mode of change and adaptation. Through this process,individual buildings can express the passage of time
5-HT1A receptor blockade reverses GABAA receptor α3 subunit-mediated anxiolytic effects on stress-induced hyperthermia
Stress-related disorders are associated with dysfunction of both serotonergic and GABAergic pathways, and clinically effective anxiolytics act via both neurotransmitter systems. As there is evidence that the GABA(A) and the serotonin receptor system interact, a serotonergic component in the anxiolytic actions of benzodiazepines could be present. The main aim of the present study was to investigate whether the anxiolytic effects of (non-)selective alpha subunit GABA(A) receptor agonists could be reversed with 5-HT1A receptor blockade using the stress-induced hyperthermia (SIH) paradigm. The 5-HT1A receptor antagonist WAY-100635 (0.1-1 mg/kg) reversed the SIH-reducing effects of the non-alpha-subunit selective GABA(A) receptor agonist diazepam (1-4 mg/kg) and the GABA(A) receptor alpha(3)-subunit selective agonist TP003 (1 mg/kg), whereas WAY-100635 alone was without effect on the SIH response or basal body temperature. At the same time, co-administration of WAY-100635 with diazepam or TP003 reduced basal body temperature. WAY-100635 did not affect the SIH response when combined with the preferential alpha(1)-subunit GABA(A) receptor agonist zolpidem (10 mg/kg), although zolpidem markedly reduced basal body temperature. The present study suggests an interaction between GABA(A) receptor alpha-subunits and 5-HT1A receptor activation in the SIH response. Specifically, our data indicate that benzodiazepines affect serotonergic signaling via GABA(A) receptor alpha(3)-subunits. Further understanding of the interactions between the GABA(A) and serotonin system in reaction to stress may be valuable in the search for novel anxiolytic drugs
A three pulse phase response curve to three milligrams of melatonin in humans
Exogenous melatonin is increasingly used for its phase shifting and soporific effects. We generated a three pulse phase response curve (PRC) to exogenous melatonin (3 mg) by administering it to free-running subjects. Young healthy subjects (n = 27) participated in two 5 day laboratory sessions, each preceded by at least a week of habitual, but fixed sleep. Each 5 day laboratory session started and ended with a phase assessment to measure the circadian rhythm of endogenous melatonin in dim light using 30 min saliva samples. In between were three days in an ultradian dim light (< 150 lux)–dark cycle (LD 2.5 : 1.5) during which each subject took one pill per day at the same clock time (3 mg melatonin or placebo, double blind, counterbalanced). Each individual's phase shift to exogenous melatonin was corrected by subtracting their phase shift to placebo (a free-run). The resulting PRC has a phase advance portion peaking about 5 h before the dim light melatonin onset, in the afternoon. The phase delay portion peaks about 11 h after the dim light melatonin onset, shortly after the usual time of morning awakening. A dead zone of minimal phase shifts occurred around the first half of habitual sleep. The fitted maximum advance and delay shifts were 1.8 h and 1.3 h, respectively. This new PRC will aid in determining the optimal time to administer exogenous melatonin to achieve desired phase shifts and demonstrates that using exogenous melatonin as a sleep aid at night has minimal phase shifting effects