Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 6. Table S5: “Genes mapped to DMP/DMR identified in at-birth samples of babies born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associations of genes mapped to significant CpG sites or differentially methylated regions identified in this study

Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 5. Table S4: “Direction of differential methylation of CpGs in DMRs of the at-birth and childhood analyses (preliminary analysis”)

Additional file 4 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 4. Table S2: “Models used in this meta-analysis study”. Inflation (lambda) and bias information of the models. Table S3: “Comparison of magnitude and direction of the FDR-significant DNA methylation signals identified in the at-birth and childhood meta-analyses”

Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 8. Table S8: “Genes mapped to DMR identified in the childhood samples of children born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associations of genes mapped to significant differentially methylated regions identified in this study

Additional file 9 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 9. “Trait Enrichment Analysis (EWAS Atlas)”. Trait names and the odds ratios for their association with CpG sites for all the models meta-analysed in this study

Additional file 7 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 7. Table S6: “Season of birth-associated differentially methylated regions (DMRs) at birth in babies born in latitudes < 50°N”. Differentially methylated regions and mapped genes identified in the at-birth samples of babies born in latitudes < 50°N (lower latitude subgroup analysis). Table S7: “Season of birth associated with differentially methylated regions (DMRs) in children born in latitudes ≥ 50°N”

Additional file 3 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Additional file 3. “PACE analysis plan for Season of Birth and methylation profiles in children (6 June 2018)”. Analysis plan that was circulated amongst the participant cohorts for the Season of Birth study