Eribulin vs. Eribulin + Bevacizumab in advanced-line treatment of Her-2 negative metastatic breast cancer

n/

Effects of Walking Endurance Reduction on Gait Stability in Patients with Stroke

Control of gait is usually altered following stroke, and it may be further compromised by overexertion and fatigue. This study aims to quantitatively assess patients' gait stability during six-minute walking, measuring upper body accelerations of twenty patients with stroke (64 ± 13 years old) and ten age-matched healthy subjects (63 ± 10 years old). Healthy subjects showed a steady gait in terms of speed and accelerations over the six minutes. Conversely, the patients unable to complete the test (n = 8) progressively reduced their walking speed (−22 ± 11%, confidence interval CI95%: −13, −29%, P = 0.046). Patients able to complete the test (n = 12) did not vary their walking speed over time (P = 0.493). However, this ability was not supported by an adequate capacity to maintain their gait stability, as shown by a progressive increase of their upper body accelerations (+5 ± 11%, CI95%: −1; +12%, P = 0.010). Walking endurance and gait stability should be both quantitatively assessed and carefully improved during the rehabilitation of patients with stroke

Screening of conditions controlling spectrophotometric sequential injection analysis

<p>Abstract</p> <p>Background</p> <p>Despite its potential benefits over univariate, chemometrics is rarely utilized for optimizing sequential injection analysis (SIA) methods. Specifically, in previous vis-spectrophotometric SIA methods, chemometrically optimized conditions were confined within flow rate and reagent concentrations while other conditions were ignored.</p> <p>Results</p> <p>The current manuscript reports, for the first time, a comprehensive screening of conditions controlling vis-spectrophotometric SIA. A new diclofenac assay method was adopted. The method was based on oxidizing diclofenac by permanganate (a major reagent) with sulfuric acid (a minor reagent). The reaction produced a spectrophotometrically detectable diclofenac form. The 2⁶full-factorial design was utilized to study the effect of volumes of reagents and sample, in addition to flow rate and concentrations of reagents. The main effects and all interaction order effects on method performance, i.e. namely sensitivity, rapidity and reagent consumption, were determined. The method was validated and applied to pharmaceutical formulations (tablets, injection and gel).</p> <p>Conclusions</p> <p>Despite 64 experiments those conducted in the current study were cumbersome, the results obtained would reduce effort and time when developing similar SIA methods in the future. It is recommended to critically optimize effective and interacting conditions using other such optimization tools as fractional-factorial design, response surface and simplex, rather than full-factorial design that used at an initial optimization stage. In vis-spectrophotometric SIA methods those involve developing reactions with two reagents (major and minor), conditions affecting method performance are in the following order: sample volume > flow rate ≈ major reagent concentration >> major reagent volume ≈ minor reagent concentration >> minor reagent volume.</p

Grattacielo Pirelli a Milano

Il Restauro del Grattacielo Pirelli, riferimento alla tradizione moderna ed internazionale, attualmente sede del Consiglio della Regione Lombardia, è descritto dai progettisti dal concept fino ai dettagli costruttivi con ricchezza di documentazione iconografica e tecnica. Tema principale del progetto è “ascoltare” la lezione di Ponti, rendere evidenti i riferimenti al carattere originario dell’edificio e, all’interno, della sua articolazione generale. Uno studio fondato sull’osservazione delle misure e dei rapporti originari, sulla comprensione e riproposizione delle logiche interne con il necessario aggiornamento funzionale, tecnico e normativo. Tre le fondamentali linee guida dell'intervento: una concezione organica, la rispondenza accurata ai principi della conservazione e del restauro, l’adeguamento agli attuali requisiti di sicurezza. comfort, risparmio energetico

Luoghi di transito – esperienze progettuali e ricerca

Presentazione del progetto: Stazione di Castellammare Centro Raddoppio Linea Circumvesuviana Torre Annunziata / Castellammare di Stabia Intervento di riqualificazione della Stazion

Corvino+Multari

Giovanni Multari e Vincenzo Corvino hanno presentato il loro lavoro, articolato in più di 15 anni di professione: concorsi vinti, progetti realizzati e pubblicati, spesso impreziositi dalla collaborazione di artisti come Mimmo Paladino, Sergio Fermariello e Nino Longobardi. Il moderatore dell dibattito, il direttore del Corriere del Mezzogiorno Marco Demarco, ha intervistato i due progettisti intorno alla loro idea di città, di architettura, di restauro

Vesuvius

Conferenza e proiezione del video "Corvino + Multari Vesuvius" di Gianpaolo De Siena, prodotto da Graus Editore e patrocinato dalla Presidenza della Regione Campani

Progetto del Complesso parrocchiale Madonna delle Grazie “Parrocchia di S.Giorgio Martire in Dresano (Mi), Diocesi di Lodi

Il contributo illustra il progetto vincitore del concorso nazionale ad inviti: Nuove chiese italiane 5 - Conferenza Episcopale Italiana, relativamente al Nuovo Complesso Parrocchiale "Madonna delle Grazie", Diocesi di Lodi, Milano