On the Cognition of States of Affairs

The theory of speech acts put forward by Adolf Reinach in his "The A Priori Foundations of the Civil Law" of 1913 rests on a systematic account of the ontological structures associated with various different sorts of language use. One of the most original features of Reinach's account lies in hIs demonstration of how the ontological structure of, say, an action of promising or of commanding, may be modified in different ways, yielding different sorts of non-standard instances of the corresponding speech act varieties. The present paper is an attempt to apply this idea of standard and modified instances of ontological structures to the realm of judgement and cognition, and thereby to develop a Reinachian theory of how intentionality is mediated through language in acts of thinking and speaking

Satellite soil moisture observations: applications in the UK and India

The India-UK Water Centre (IUKWC) promotes cooperation and collaboration between the complementary priorities of NERC-MoES water security research. The State of Science Brief was produced as an output from an India-UK Water Centre supported Pump Priming Project on Synergistic utilisation of EO-based soil moisture observations: Applications in the UK and India

The Effect of Nitrogen Fertiliser and Season on the \u3cem\u3ein Situ\u3c/em\u3e Degradability of Irish Perennial Ryegrass in Cattle

In light of increasing environmental and economic pressure on agriculture to utilise resources more efficiently, protein feeding and its effects are fundamentally important. As grazed grass is the predominant feed in Irish dairy and beef cattle production systems, it is necessary to establish protein values for different grass varieties and cultivars fed. It is also important to investigate the extent of ruminal nitrogen (N) degradability for these grasses since this characteristic greatly influences environmentally damaging urinary N excretion

Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity

The WMI and WLI inbred rats were generated from the stress-prone, and not yet fully inbred, Wistar Kyoto (WKY) strain. These were selected using bi-directional selection for immobility in the forced swim test and were then sib-mated for over 38 generations. Despite the low level of genetic diversity among WKY progenitors, the WMI substrain is significantly more vulnerable to stress relative to the counter-selected WLI strain. Here we quantify numbers and classes of genomic sequence variants distinguishing these substrains with the long term goal of uncovering functional and behavioral polymorphism that modulate sensitivity to stress and depression-like phenotypes. DNA from WLI and WMI was sequenced using Illumina xTen, IonTorrent, and 10X Chromium linked-read platforms to obtain a combined coverage of ~ 100X for each strain. We identified 4,296 high quality homozygous SNPs and indels between the WMI and WLI. We detected high impact variants in genes previously implicated in depression (e.g. Gnat2), depression-like behavior (e.g. Prlr, Nlrp1a), other psychiatric disease (e.g. Pou6f2, Kdm5a, Reep3, Wdfy3), and responses to psychological stressors (e.g. Pigr). High coverage sequencing data confirm that the two substrains are nearly coisogenic. Nonetheless, the small number of sequence variants contributes to numerous well characterized differences including depression-like behavior, stress reactivity, and addiction related phenotypes. These selected substrains are an ideal resource for forward and reverse genetic studies using a reduced complexity cross

Post-Disaster Housing Reconstruction in Sri Lanka: What Methodology?

Research methodology is the procedural framework within which the research is conducted. This includes the overall approach to a problem that could be put into practice in a research process, from the theoretical underpinning to the collection and analysis of data. Choice of methodology depends on the primary drivers: topic to be researched and the specific research questions. Hence, methodological perspectives of managing stakeholder expectations of PDHR context are composed of research philosophies, research strategy, research design, and research techniques. This research belonged to social constructivism or interpretivism within a philosophical continuum. The nature of the study was more toward subjectivism where human behavior favored voluntary stance. Ontological, methodological, epistemological, and axiological positioning carried the characteristics of idealism, ideographic, anti-positivism, and value laden, respectively. Data collection comprises two phases, preliminary and secondary. Exploratory interviews with construction experts in the United Kingdom and Sri Lanka were carried out to refine the interview questions and identify the case studies. Case study interviews during the secondary phase took place in Sri Lanka. Data collected at the preliminary stage were used to assess the attributes of power, legitimacy/proximity, and urgency of stakeholders to the project using Stakeholder Circle™ software. Moreover, the data collected at secondary phase via case studies will be analyzed with NVivo 8. This article aims to discuss these methodological underpinnings in detail applied in a post-disaster housing reconstruction context in Sri Lanka

Experimental study at prototype scale of a self-priming free surface siphon

This study is within the frame of the construction of the rail link between Geneva Cornavin station, Eaux-Vives station and Annemasse (CEVA). The project area is located at a cut-and-cover tunnel built by slurry walls located in the alluvium of the Foron River. The installation of the covered trench cuts the groundwater table flow, which causes a rise of the water table in spite of the partial evacuation by the Foron. It is therefore planned to add about thirty wells in order to transit the waters of the aquifer from one side of the tunnel to the other. A thorough reflection allowed to find an alternative solution to traditional pumping consisting of putting in place self-priming multiphase siphons which forms the basis of the following study. The operating principle of the system is based on the maintenance of a free-surface vortex in a vacuum in what will be called the sealed box which functions by keeping the siphon primed to allow water to be transferred from either side of the gallery. This study explores the performance of a physical model of the system with the following objectives: (1) To characterize the initiation and stability conditions of the system by maintaining the vacuum in the sealed box and (2) to characterize the limiting operating conditions of the system in relation to the ground water table levels which relates to insufficient air entrainment due to low outflow or submergence of the sealed box. The experimental installation is fabricated at a scale of 1:1 so as not to introduce scale effects by the presence of air, the water-air mixture and the free-surface vortex in a vacuum atmosphere

Health Literacy and Medication Practices in Senior Housing Residents

Objective: To conduct a descriptive analysis of health literacy, knowledge of prescribed medications, and methods of administering medications in a cohort of senior housing residents.https://scholarworks.uvm.edu/comphp_gallery/1027/thumbnail.jp

Assessment of Radiometer Calibration With GPS Radio Occultation for the MiRaTA CubeSat Mission

The microwave radiometer technology acceleration (MiRaTA) is a 3U CubeSat mission sponsored by the NASA Earth Science Technology Office. The science payload on MiRaTA consists of a triband microwave radiometer and global positioning system (GPS) radio occultation (GPSRO) sensor. The microwave radiometer takes measurements of all-weather temperature (V-band, 50-57 GHz), water vapor (G-band, 175-191 GHz), and cloud ice (G-band, 205 GHz) to provide observations used to improve weather forecasting. The Aerospace Corporation's GPSRO experiment, called the compact total electron content and atmospheric GPS sensor (CTAGS), measures profiles of temperature and pressure in the upper troposphere/lower stratosphere (~20 km) and electron density in the ionosphere (over 100 km). The MiRaTA mission will validate new technologies in both passive microwave radiometry and GPSRO: 1) new ultracompact and low-power technology for multichannel and multiband passive microwave radiometers, 2) the application of a commercial off-the-shelf GPS receiver and custom patch antenna array technology to obtain neutral atmospheric GPSRO retrieval from a nanosatellite, and 3) a new approach to space-borne microwave radiometer calibration using adjacent GPSRO measurements. In this paper, we focus on objective 3, developing operational models to meet a mission goal of 100 concurrent radiometer and GPSRO measurements, and estimating the temperature measurement precision for the CTAGS instrument based on thermal noise Based on an analysis of thermal noise of the CTAGS instrument, the expected temperature retrieval precision is between 0.17 and 1.4 K, which supports the improvement of radiometric calibration to 0.25 K

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Peer reviewedPublisher PD