4,909 research outputs found
Dynamical Electroweak Breaking and Latticized Extra Dimensions
Using gauge invariant effective Lagrangians in 1+3 dimensions describing the
Standard Model in 1+4 dimensions, we explore dynamical electroweak symmetry
breaking. The Top Quark Seesaw model arises naturally, as well as the full CKM
structure. We include a discussion of effects of warping, and indicate how
other dynamical schemes may also be realized.Comment: 30 pages, 12 figure
Finding Z' bosons coupled preferentially to the third family at CERN LEP and the Fermilab Tevatron
Z' bosons that couple preferentially to the third generation fermions can
arise in models with extended weak (SU(2)xSU(2)) or hypercharge (U(1)xU(1))
gauge groups. We show that existing limits on quark-lepton compositeness set by
the LEP and Tevatron experiments translate into lower bounds of order a few
hundred GeV on the masses of these Z' bosons. Resonances of this mass can be
directly produced at the Tevatron. Accordingly, we explore in detail the limits
that can be set at Run II using the process p pbar -> Z' -> tau tau -> e mu. We
also comment on the possibility of using hadronically-decaying taus to improve
the limits.Comment: LaTeX2e, 24 pages (including title page), 13 figures; version 2:
corrected typographical errors and bad figure placement; version 3: added
references and updated introduction; version 4: changes to compensate for old
latex version on arXiv server; version 5: additional references, and embedded
fonts in eps files for PRD; version 6: corrected some minor typos to address
PRD referee's comment
The structure of electroweak corrections due to extended gauge symmetries
This paper studies models with extended electroweak gauge sectors of the form
SU(2) x SU(2) x U(1) x [SU(2) or U(1)]. We establish the general behavior of
corrections to precision electroweak observables in this class of theories and
connect our results to previous work on specific models whose electroweak
sectors are special cases of our extended group.Comment: 18 pages, 2 figures; added a referenc
Effects of intersegmental transfers on target location by proteins
We study a model for a protein searching for a target, using facilitated
diffusion, on a DNA molecule confined in a finite volume. The model includes
three distinct pathways for facilitated diffusion: (a) sliding - in which the
protein diffuses along the contour of the DNA (b) jumping - where the protein
travels between two sites along the DNA by three-dimensional diffusion, and
finally (c) intersegmental transfer - which allows the protein to move from one
site to another by transiently binding both at the same time. The typical
search time is calculated using scaling arguments which are verified
numerically. Our results suggest that the inclusion of intersegmental transfer
(i) decreases the search time considerably (ii) makes the search time much more
robust to variations in the parameters of the model and (iii) that the optimal
search time occurs in a regime very different than that found for models which
ignore intersegmental transfers. The behavior we find is rich and shows
surprising dependencies, for example, on the DNA length.Comment: 40 pages, 14 figure
Decreasing childhood mortality and increasing proportion of malaria deaths in rural Burkina Faso
Beautiful Mirrors and Precision Electroweak Data
The Standard Model (SM) with a light Higgs boson provides a very good
description of the precision electroweak observable data coming from the LEP,
SLD and Tevatron experiments. Most of the observables, with the notable
exception of the forward-backward asymmetry of the bottom quark, point towards
a Higgs mass far below its current experimental bound. The disagreement, within
the SM, between the values for the weak mixing angle as obtained from the
measurement of the leptonic and hadronic asymmetries at lepton colliders, may
be taken to indicate new physics contributions to the precision electroweak
observables. In this article we investigate the possibility that the inclusion
of additional bottom-like quarks could help resolve this discrepancy. Two
inequivalent assignments for these new quarks are analysed. The resultant fits
to the electroweak data show a significant improvement when compared to that
obtained in the SM. While in one of the examples analyzed, the exotic quarks
are predicted to be light, with masses below 300 GeV, and the Higgs tends to be
heavy, in the second one the Higgs is predicted to be light, with a mass below
250 GeV, while the quarks tend to be heavy, with masses of about 800 GeV. The
collider signatures associated with the new exotic quarks, as well as the
question of unification of couplings within these models and a possible
cosmological implication of the new physical degrees of freedom at the weak
scale are also discussed.Comment: 21 pages, 4 embedded postscript figures, LaTeX. Two minor corrections
performe
Infectious Disease Ontology
Technological developments have resulted in tremendous increases in the volume and diversity of the data and information that must be processed in the course of biomedical and clinical research and practice. Researchers are at the same time under ever greater pressure to share data and to take steps to ensure that data resources are interoperable. The use of ontologies to annotate data has proven successful in supporting these goals and in providing new possibilities for the automated processing of data and information. In this chapter, we describe different types of vocabulary resources and emphasize those features of formal ontologies that make them most useful for computational applications. We describe current uses of ontologies and discuss future goals for ontology-based computing, focusing on its use in the field of infectious diseases. We review the largest and most widely used vocabulary resources relevant to the study of infectious diseases and conclude with a description of the Infectious Disease Ontology (IDO) suite of interoperable ontology modules that together cover the entire infectious disease domain
Qubit Disentanglement and Decoherence via Dephasing
We consider whether quantum coherence in the form of mutual entanglement
between a pair of qubits is susceptible to decay that may be more rapid than
the decay of the coherence of either qubit individually. An instance of
potential importance for solid state quantum computing arises if embedded
qubits (spins, quantum dots, Cooper pair boxes, etc.) are exposed to global and
local noise at the same time. Here we allow separate phase-noisy channels to
affect local and non-local measures of system coherence. We find that the time
for decay of the qubit entanglement can be significantly shorter than the time
for local dephasing of the individual qubits.Comment: REVTeX, 9 pages, 1 figure, v2 with minor changes, reference adde
Identification of antigens presented by MHC for vaccines against tuberculosis
Mycobacterium tuberculosis (M.tb) is responsible for more deaths globally than any other pathogen. The only available vaccine, bacillus Calmette-Guérin (BCG), has variable efficacy throughout the world. A more effective vaccine is urgently needed. The immune response against tuberculosis relies, at least in part, on CD4+ T cells. Protective vaccines require the induction of antigen-specific CD4+ T cells via mycobacterial peptides presented by MHC class-II in infected macrophages. In order to identify mycobacterial antigens bound to MHC, we have immunoprecipitated MHC class-I and class-II complexes from THP-1 macrophages infected with BCG, purified MHC class-I and MHC class-II peptides and analysed them by liquid chromatography tandem mass spectrometry. We have successfully identified 94 mycobacterial peptides presented by MHC-II and 43 presented by MHC-I, from 76 and 41 antigens, respectively. These antigens were found to be highly expressed in infected macrophages. Gene ontology analysis suggests most of these antigens are associated to membranes and involved in lipid biosynthesis and transport. The sequences of selected peptides were confirmed by spectral match validation and immunogenicity evaluated by IFN-gamma ELISpot against peripheral blood mononuclear cell from volunteers vaccinated with BCG, M.tb latently infected subjects or patients with tuberculosis disease. Three antigens were expressed in viral vectors, and evaluated as vaccine candidates alone or in combination in a murine aerosol M.tb challenge model. When delivered in combination, the three candidate vaccines conferred significant protection in the lungs and spleen compared with BCG alone, demonstrating proof-of-concept for this unbiased approach to identifying new candidate antigens
Scaling of the distribution of fluctuations of financial market indices
We study the distribution of fluctuations over a time scale (i.e.,
the returns) of the S&P 500 index by analyzing three distinct databases.
Database (i) contains approximately 1 million records sampled at 1 min
intervals for the 13-year period 1984-1996, database (ii) contains 8686 daily
records for the 35-year period 1962-1996, and database (iii) contains 852
monthly records for the 71-year period 1926-1996. We compute the probability
distributions of returns over a time scale , where varies
approximately over a factor of 10^4 - from 1 min up to more than 1 month. We
find that the distributions for 4 days (1560 mins) are
consistent with a power-law asymptotic behavior, characterized by an exponent
, well outside the stable L\'evy regime . To
test the robustness of the S&P result, we perform a parallel analysis on two
other financial market indices. Database (iv) contains 3560 daily records of
the NIKKEI index for the 14-year period 1984-97, and database (v) contains 4649
daily records of the Hang-Seng index for the 18-year period 1980-97. We find
estimates of consistent with those describing the distribution of S&P
500 daily-returns. One possible reason for the scaling of these distributions
is the long persistence of the autocorrelation function of the volatility. For
time scales longer than days, our results are
consistent with slow convergence to Gaussian behavior.Comment: 12 pages in multicol LaTeX format with 27 postscript figures
(Submitted to PRE May 20, 1999). See
http://polymer.bu.edu/~amaral/Professional.html for more of our work on this
are
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