Epidemiological profile of laryngeal cancer in Hospital de Clínicas de Porto Alegre

OBJETIVO: O objetivo foi documentar a distribuição e o padrão de comportamento deste tumor entre os nossos pacientes. MATERIAIS E MÉTODOS: Foi realizado um estudo retrospectivo dos pacientes com diagnóstico de câncer de laringe atendidos no Hospital de Clínicas de Porto Alegre entre 1990 e 1996. RESULTADOS: Foram encontrados 242 casos, a maioria da raça branca (94,2%). A divisão por faixa etária mostrou um pico do ocorrência na sétima década de vida e a proporção de homens em relação à mulheres foi de 15:1. O tipo histológico mais comum foi carcinoma epidermóide (98,76%) e o sítio mais freqüentemente acometido foi a glote (44,7%), conseqüentemente, o sintoma mais comum na apresentação foi a disfonia (76,5%). Os pacientes com tumores na supraglote apresentaram, principalmente, disfagia e, aqueles com tumores transglóticos, dispnéia. Quanto ao estadiamento, 43,2% estavam no estágio IV no momento do diagnóstico. Os tumores localizados na supraglote estão relacionados com pior prognóstico, nesta amostra 38,3% dos pacientes com câncer na supraglote estavam no estágio IV, enquanto que a maioria dos tumores glóticos (74,2%) estavam no estágio I. A cirurgia total foi o tratamento mais realizado (50,7%). CONCLUSÃO: O diagnóstico do câncer de laringe no Hospital de Clínicas de Porto Alegre é feito, em sua maior parte, em estágio avançado, tornando o prognóstico desses pacientes bastante reservado.OBJECTIVES: The aim was to document the distribution and pattern of behavior of this tumor among our patients. MATERIALS AND METHODS: A retrospective study of patients with diagnosis of laryngeal cancer seen in the Hospital de Clínicas de Porto Alegre between 1990 to 1996 was carried out. RESULTS: There were 242 cases, the majority of whom were from the white race (94,2%). The peak incidence was in the seventh decade of life and male to female ratio was 15:1. The most common histological type was squamous cell carcinoma (98,76%) and by site, glottic involvement was the most frequent (44,7%), and so the most common symptom at presentation was hoarseness (76,5%). Supraglottic tumors presented, mainly, with dysphagia and the transglottics with dyspnea. As to staging, 43,3% were in IV stage at the diagnosis. The supraglottic tumors were, mainly, in the stage IV (38,3%), while the majority of glottic tumors (74,2%) were in the stage I, its reflect a worse prognosis for the supraglottic tumors. The total surgery was the most frequent treatment performed (50,7%). CONCLUSIONS: The laryngeal cancer diagnosis in the Hospital de Clínicas de Porto Alegre is done at a late stage, making the patient’s prognosis really reserved

Epidemiological profile of laryngeal cancer in Hospital de Clínicas de Porto Alegre

OBJETIVO: O objetivo foi documentar a distribuição e o padrão de comportamento deste tumor entre os nossos pacientes. MATERIAIS E MÉTODOS: Foi realizado um estudo retrospectivo dos pacientes com diagnóstico de câncer de laringe atendidos no Hospital de Clínicas de Porto Alegre entre 1990 e 1996. RESULTADOS: Foram encontrados 242 casos, a maioria da raça branca (94,2%). A divisão por faixa etária mostrou um pico do ocorrência na sétima década de vida e a proporção de homens em relação à mulheres foi de 15:1. O tipo histológico mais comum foi carcinoma epidermóide (98,76%) e o sítio mais freqüentemente acometido foi a glote (44,7%), conseqüentemente, o sintoma mais comum na apresentação foi a disfonia (76,5%). Os pacientes com tumores na supraglote apresentaram, principalmente, disfagia e, aqueles com tumores transglóticos, dispnéia. Quanto ao estadiamento, 43,2% estavam no estágio IV no momento do diagnóstico. Os tumores localizados na supraglote estão relacionados com pior prognóstico, nesta amostra 38,3% dos pacientes com câncer na supraglote estavam no estágio IV, enquanto que a maioria dos tumores glóticos (74,2%) estavam no estágio I. A cirurgia total foi o tratamento mais realizado (50,7%). CONCLUSÃO: O diagnóstico do câncer de laringe no Hospital de Clínicas de Porto Alegre é feito, em sua maior parte, em estágio avançado, tornando o prognóstico desses pacientes bastante reservado.OBJECTIVES: The aim was to document the distribution and pattern of behavior of this tumor among our patients. MATERIALS AND METHODS: A retrospective study of patients with diagnosis of laryngeal cancer seen in the Hospital de Clínicas de Porto Alegre between 1990 to 1996 was carried out. RESULTS: There were 242 cases, the majority of whom were from the white race (94,2%). The peak incidence was in the seventh decade of life and male to female ratio was 15:1. The most common histological type was squamous cell carcinoma (98,76%) and by site, glottic involvement was the most frequent (44,7%), and so the most common symptom at presentation was hoarseness (76,5%). Supraglottic tumors presented, mainly, with dysphagia and the transglottics with dyspnea. As to staging, 43,3% were in IV stage at the diagnosis. The supraglottic tumors were, mainly, in the stage IV (38,3%), while the majority of glottic tumors (74,2%) were in the stage I, its reflect a worse prognosis for the supraglottic tumors. The total surgery was the most frequent treatment performed (50,7%). CONCLUSIONS: The laryngeal cancer diagnosis in the Hospital de Clínicas de Porto Alegre is done at a late stage, making the patient’s prognosis really reserved

BB flavour tagging using charm decays at the LHCb experiment

An algorithm is described for tagging the flavour content at production of neutral $B$ mesons in the LHCb experiment. The algorithm exploits the correlation of the flavour of a $B$ meson with the charge of a reconstructed secondary charm hadron from the decay of the other $b$ hadron produced in the proton-proton collision. Charm hadron candidates are identified in a number of fully or partially reconstructed Cabibbo-favoured decay modes. The algorithm is calibrated on the self-tagged decay modes $B^+ \to J/\psi \, K^+$ and $B^0 \to J/\psi \, K^{*0}$ using $3.0\mathrm{\,fb}^{-1}$ of data collected by the LHCb experiment at $pp$ centre-of-mass energies of $7\mathrm{\,TeV}$ and $8\mathrm{\,TeV}$. Its tagging power on these samples of $B \to J/\psi \, X$ decays is $(0.30 \pm 0.01 \pm 0.01) \%$.An algorithm is described for tagging the flavour content at production of neutral B mesons in the LHCb experiment. The algorithm exploits the correlation of the flavour of a B meson with the charge of a reconstructed secondary charm hadron from the decay of the other b hadron produced in the proton-proton collision. Charm hadron candidates are identified in a number of fully or partially reconstructed Cabibbo-favoured decay modes. The algorithm is calibrated on the self-tagged decay modes B(+) → J/ψ K(+) and B(0) → J/ψ K(*0) using 3.0 fb(−)(1) of data collected by the LHCb experiment at pp centre-of-mass energies of 7 TeV and 8 TeV. Its tagging power on these samples of B → J/ψ X decays is (0.30 ± 0.01 ± 0.01)%.An algorithm is described for tagging the flavour content at production of neutral $B$ mesons in the LHCb experiment. The algorithm exploits the correlation of the flavour of a $B$ meson with the charge of a reconstructed secondary charm hadron from the decay of the other $b$ hadron produced in the proton-proton collision. Charm hadron candidates are identified in a number of fully or partially reconstructed Cabibbo-favoured decay modes. The algorithm is calibrated on the self-tagged decay modes $B^+ \to J/\psi \, K^+$ and $B^0 \to J/\psi \, K^{*0}$ using $3.0\mathrm{\,fb}^{-1}$ of data collected by the LHCb experiment at $pp$ centre-of-mass energies of $7\mathrm{\,TeV}$ and $8\mathrm{\,TeV}$. Its tagging power on these samples of $B \to J/\psi \, X$ decays is $(0.30 \pm 0.01 \pm 0.01) \%$

Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes

10.1161/CIRCULATIONAHA.119.042551CIRCULATION140191578-158

Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial

10.1161/CIRCULATIONAHA.118.038840CIRCULATION1402103-11