722 research outputs found

    Environmental Mechanism Designs in a New Order of Regulatory Capitalism

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    Complexity of environmental programs is most apparent with information asymmetries, making the design of efficient mechanisms particularly challenging. As developed theoretically in this paper, a new regulatory capitalism paradigm mating voluntary agreements with environmental education can produce outcomes at least as efficient as voluntary agreements alone. Such a design exploits a key difference between voluntary agreements versus educational programs in terms of their impact on agents' incentive compatibilities. Specifically, in a principal-agent model, voluntary agreements are associated with an incentive-compatibility constraint, whereas educational programs are not. The efficient bundle will likely consist of a set of education programs and voluntary agreements. With the new order of regulatory capitalism, it is time to concentrate on removing barriers yielding inefficient mono-mechanism design and start constructing multidimensional incentives to efficiently allocate effort toward environmental and economic goals.Command and control, environmental education, environmental policy, voluntary agreements, Environmental Economics and Policy,

    A note on the use of FTA™ technology for storage of blood samples for DNA analysis and removal of PCR inhibitors

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    peer-reviewedFTA™ technology is widely used across many molecular disciplines for sample capture, storage and analysis. The use of this technology for the long-term storage of blood samples for DNA analysis was examined as well as its potential to remove inhibitors from DNA samples previously extracted from blood with PCR inhibitors remaining. It was found that blood spots stored on FTA™ cards for 8 years at room temperature gave successful PCR products and that FTA™ cards are a useful tool for removing substances in samples which interfere with or inhibit, the PCR reaction

    Investigation of Prolific Sheep from UK and Ireland for Evidence on Origin of the Mutations in BMP15 (FecXG, FecXB) and GDF9 (FecGH) in Belclare and Cambridge Sheep

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    peer-reviewedThis paper concerns the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecXG and FecXB) and the third (FecGH) in GDF9. All three mutations segregate in Belclare sheep while one, FecXB, has not been found in the Cambridge. Both Belclare and Cambridge breeds are relatively recently developed composites that have common ancestry through the use of genetic material from the Finnish Landrace and Lleyn breeds. The development of both composites also involved major contributions from exceptionally prolific ewes screened from flocks in Ireland (Belclare) and Britain (Cambridge) during the 1960s. The objective of the current study was to establish the likely origin of the mutations (FecXG, FecXB and FecGH) through analysis of DNA from Finnish Landrace and Lleyn sheep, and Galway and Texel breeds which contributed to the development of the Belclare breed. Ewes with exceptionally high prolificacy (hyper-prolific ewes) in current flocks on Irish farms were identified to simulate the screening of ewes from Irish flocks in the 1960s. DNA was obtained from: prolific ewes in extant flocks of Lleyn sheep (n = 44) on the Lleyn peninsula in Wales; hyper-prolific ewes (n = 41); prolific Galway (n = 41) ewes; Finnish Landrace (n = 124) and Texel (n = 19) ewes. The FecXG mutation was identified in Lleyn but not in Finnish Landrace, Galway or Texel sheep; FecXB was only found among the hyper-prolific ewes. The FecGH mutation was identified in the sample of Lleyn sheep. It was concluded from these findings that the Lleyn breed was the most likely source of the FecXG and FecGH mutations in Belclare and Cambridge sheep and that the FecXB mutation came from the High Fertility line that was developed using prolific ewes selected from commercial flocks in Ireland in the 1960′s and subsequently used in the genesis of the Belclare.Financial support through the Teagasc Walsh Fellowship Scheme, Genesis Faraday SPARK award (Lleyn survey) and Science Foundation Ireland (07/SRC/B1156) is gratefully acknowledged

    United States

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    Racial Disparities in Intravenous Recombinant Tissue Plasminogen Activator Use Persist at Primary Stroke Centers.

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    BACKGROUND: Primary stroke centers (PSCs) utilize more recombinant tissue plasminogen activator (rt-PA) than non-PSCs. The impact of PSCs on racial disparities in rt-PA use is unknown. METHODS AND RESULTS: We used data from the Nationwide Inpatient Sample from 2004 to 2010, limited to states that publicly reported hospital identity and race. Hospitals certified as PSCs by The Joint Commission were identified. Adults with a diagnosis of ischemic stroke were analyzed. Rt-PA use was defined by the International Classification of Diseases, 9th Revision procedure code 99.10. Discharges (304 152 patients) from 26 states met eligibility criteria, and of these 71.5% were white, 15.0% black, 7.9% Hispanic, and 5.6% other. Overall, 24.7% of white, 27.4% of black, 16.2% of Hispanic, and 29.8% of other patients presented to PSCs. A higher proportion received rt-PA at PSCs than non-PSCs in all race/ethnic groups (white 7.6% versus 2.6%, black 4.8% versus 2.0%, Hispanic 7.1% versus 2.4%, other 7.2% versus 2.5%, all P CONCLUSIONS: Racial disparities in intravenous rt-PA use were not reduced by presentation to PSCs. Black patients were less likely to receive thrombolytic treatment than white patients at both non-PSCs and PSCs. Hispanic patients were less likely to be seen at PSCs relative to white patients and were less likely to receive intravenous rt-PA in the fully adjusted model

    Femtosecond Laser Photoionization Time-of-Flight Mass Spectrometry of Nitro-aromatic Explosives and Explosives Related Compounds

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    The ultrafast laser-induced photoionization and photodissociation processes of the nitroaromatic containing explosive and explosive related compounds (ERCs) nitrobenzene (NB), 1,3-dinitrobenzene (DNB), m-nitrotoluene (MNT), 2,4-dinitrotoluene (DNT), and 2,4,6-trinitrotoluene (TNT) have been investigated at three laser wavelengths and power densities using a time-of-flight mass spectrometer. Examination of the mass spectra of these compounds reveals the enhanced formation of the molecular ion [M+] when ultraviolet (332 nm) and visible (495 nm) light is used relative to infrared (795 nm) radiation. In addition, at 795 nm and a power density of 3.5 Ă— 1014 W/cm2, the presence of a competition between multiphoton ionization (MPI) and Coulomb explosion (CE) channels is revealed by peak shape analysis, and is thought to be operative under these conditions for all of the molecules investigated

    Cardiologists, the PINNACLE Registry, and the “Meaningful Use” of Electronic Health Records

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    crisscrossing Science Episode 039: Nuclear Winter

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    In this episode, Chris Gaiser (professor of biology at Linfield College) and Mike Crosser (professor of physics at Linfield College) invite author John Coster-Mullen to discuss the technology behind the first atomic weapons that were dropped above Japan during World War II. We learn about the design differences between the bombs dropped over Hiroshima and Nagasaki and why these differences mattered. This episode references content discussed in Episode 024, which explains how nuclear power works
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