Bone marrow-derived cells in ocular neovascularization: contribution and mechanisms

Ocular neovascularization often leads to severe vision loss. The role of bone marrow-derived cells (BMCs) in the development of ocular neovascularization, and its significance, is increasingly being recognized. In this review, we discuss their contribution and the potential mechanisms that mediate the effect of BMCs on the progression of ocular neovascularization. The sequence of events by which BMCs participate in ocular neovascularization can be roughly divided into four phases, i.e., mobilization, migration, adhesion and differentiation. This process is delicately regulated and liable to be affected by multiple factors. Cytokines such as vascular endothelial growth factor, granulocyte colony-stimulating factor and erythropoietin are involved in the mobilization of BMCs. Studies have also demonstrated a key role of cytokines such as stromal cell-derived factor-1, tumor necrosis factor-α, as well as vascular endothelial growth factor, in regulating the migration of BMCs. The adhesion of BMCs is mainly regulated by vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and vascular endothelial cadherin. However, the mechanisms regulating the differentiation of BMCs are largely unknown at present. In addition, BMCs secrete cytokines that interact with the microenvironment of ocular neovascularization; their contribution to ocular neovascularization, especially choroidal neovascularization, can be aggravated by several risk factors. An extensive regulatory network is thought to modulate the role of BMCs in the development of ocular neovascularization. A comprehensive understanding of the involved mechanisms will help in the development of novel therapeutic strategies related to BMCs. In this review, we have limited the discussion to the recent progress in this field, especially the research conducted at our laboratory

Multi-objective optimization of ultrasonic-assisted magnetic abrasive finishing process

This paper is closed access until 23 November 2019.Ultrasonic-assisted magnetic abrasive finishing (UAMAF) is an advanced abrasive finishing process that finishes a workpiece surface effectually when compared to a traditional magnetic abrasive finishing process in the order of nanometer. A change of surface roughness and material removal rate are two important factors determining the efficacy of the process. These two factors affect the surface quality and production time and, thereby, a total production cost. The finishing performed at higher material removal rates leads to a loss in shape/form accuracy of the surface. At the same time, increasing the rate of change of surface roughness increases loss of material. For an optimized finishing process, a compromise has to be made between the change of surface roughness and the material removal (loss). In this work, a multi-objective optimization technique based on genetic algorithm is used to optimize the finishing parameters in the UAMAF processes. A fuzzy-set-based strategy for a higher level decision is also discussed. The results of the optimization based on a mathematical model of the process are validated with the experimental results and are found to be in compliance