Proposed Web Application for Guidance and Support of Students: SmartLAD

SmartLAD is a Support Platform that connects students, mentors, and professionals of the field and enables them to share their knowledge and experience. We equip the students with a powerful network to rely on, skill-oriented courses that impart real-life skills, and experienced mentors to guide them. Our platform helps students to stay focused on their goals and keep on working hard to achieve their dreams. SmartLAD works as a Support Platform that helps students in their journey of being successful and excelling in their careers by providing them with skills, resources, guidance, and network. We help the students by providing them with a Network that the students can use without any charges and limits and can connect to people and share knowledge

Plasmodium Vivax Associated Myocarditis

Plasmodium infection in human beings is often associated with complications. Complications such as cerebral malaria, acute respiratory distress syndrome, acute kidney injury and cardiac complications including myocarditis, pericarditis and hypoglycaemia may be seen in infection by Plasmodium falciparum. However, these complications have rarely been reported with Plasmodium vivax infections. Myopericarditis complicating P. vivax malaria is particularly rare and only a few cases have been reported so far. We report on a case of myopericarditis due to P. vivax malaria to add to the literatur

Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis

We present a rare case of a 23-year-old male incidentally detected with hepatitis B virus (HBV) infection presenting with features suggestive of HBV-associated nephropathy. A renal biopsy specimen suggested a mesangioproliferative glomerulonephritis with a full-house pattern on immunoflourescence consistent with a diagnosis of diffuse lupus nephritis. Glomerular HbeAg and HbsAg antigens were not detectable by immunofluorescence. Antiviral therapy was instituted to suppress viral replication, thereby leading to clinical and virological remission, including that of the glomerulonephritis, without the need for additional immunosuppressant therapy. This case depicts the uniqueness of the presentation of the two conditions mimicking each other, the strategy adopted to prevent the activation of viral replication and the achievement of clinical remission

Haploidentical stem cell transplant: Established treatment, expanding horizons

Haploidentical stem cell transplantation offers an oppurtunity for transplant for almost all patients for whom transplant is indicated. Traditionally, it is associated with higher incidence of graft failure, graft vs host disease and non relapse mortality as compared to matched donor transplant. However, recent advances in the field have tried to mitigate these issues and offer haploidentical transplant as a safe and viable option. In this review, we shall discuss the basics of haploidentical transplantation, how to choose the best donor amongst various haploidentical donors available and understand the various recent advances in the field of haploidentical transplantation and how they addressed the problems associated with it and make it a feasible alternative to matched sibling or unrelated transplant in various diseases

An expert system on diagnosis of mental diseases

Mental disorder is one of the most serious problems in today's time. Mental disorders can be classified into different sub-disorders according to changes in human behavior and mental condition. According to reports one out of seven people suffered from mental disorders. In this research paper, our main emphasis is to build an expert system that diagnoses people based on their symptoms, so people can diagnose themselves early before going to the doctor. Expert Systems are one of the most important applications in artificial intelligence that solves complex problems without human help. We provide different rules, facts, and relationships among different symptoms in our knowledge base, from which users can query their problems and get their results. We used SWI-prolog to build an expert system. There are a few types of disorders, such as mental disorders, neurodevelopmental disorders, eating disorders, etc

Developed an expert system for analysis of Covid-19 affected

The expert system solves problems within a specific area of the knowledge base. Prolog is a logical programming language which works on its knowledge base and effectively can be used to develop an expert system. Covid 19 is a pandemic deices and an expert system can be developed to diagnose this disease with the help of its symptoms that can be used as a knowledge base in Prolog. This expert system can make a fast diagnosis process for the covid 19 which is important to prevent the spread of the virus. Here we developed an expert system using prolog for diagnosis purposes. Like humans, these systems can get better with time as they gain more experience. Expert systems combine their experiences and expertise into a knowledge base that is then used by an inference or rules engine, a set of rules that the software employs, to apply to certain scenarios. Prolog is ideal for use with intelligent systems for a few reasons. Prolog can be viewed as a straightforward theorem prover or inference engine that derives from predefined rules. With the help of Prolog's built-in search and backtracking techniques, simple expert systems can be created

Evaluation of platelet surface glycoproteins in patients with Glanzmann thrombasthenia: Association with bleeding symptoms

Background & objectives: Glanzmann thrombasthenia (GT) is a rare, inherited autosomal recessive disorder characterized by qualitative or quantitative deficiency of integrin αIIbβ3 [glycoprotein IIb (GPIIb)/IIIa, CD41/CD61] diagnosed by absent or reduced platelet aggregation to physiological agonists, namely, collagen, adenosine-di-phosphate, epinephrine and arachidonic acid. The objective of this study was to quantitate platelet surface GPs, classify GT patients and relate the results with the severity of bleeding and platelet aggregation studies. Methods: Fifty one patients of GT diagnosed by platelet aggregation studies were evaluated for the expression of CD41, CD61, CD42a and CD42b on platelet surface by flow cytometry. The association between the clinical phenotype based on bleeding score and GT subtype on flow cytometric evaluation was assessed. Results: Twenty four (47%) patients of GT were classified as type I (as CD41/CD61 were virtually absent, <5%), six (11.8%) patients as type II (5-20% CD41/CD61) and 21 (41.2%) as type III or GT variants as they had near normal levels of CD41 and CD61. Type III GT patients had significantly lower numbers of severe bleeders (P=0.034), but the severity of bleeding did not vary significantly in type I and II GT patients. In all GT patients, mean CD41 expression was found to be lower than mean CD61 expression (P=0.002). Interpretation & conclusions: Type I GT was found most common in our patients and with lowered mean CD41 expression in comparison with CD61. Type III GT patients had significantly lower numbers of severe bleeders, but the severity of bleeding did not vary significantly in type I and II GT patients