New sesquiterpene quinols from a Micronesian sponge, Aka sp

Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not

Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean <i>Monadenium lugardae</i>

The Zimbabwean medicinal plant <i>Monadenium lugardae</i> was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (<b>1</b>–<b>4</b>) were isolated, accompanied by four previously known triterpenes (<b>5</b>–<b>8</b>). Against a panel of human tumor cell lines, lugardstatins 1 (<b>1</b>) and 2 (<b>2</b>) had good cancer cell growth inhibitory activity. All of the triterpene structures (<b>1</b>–<b>8</b>) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis