Enthalpies of fusion and enthalpies of solvation of aromatic hydrocarbons derivatives: Estimation of sublimation enthalpies at 298.15 K

© 2016 Elsevier B.V. All rights reserved.Enthalpy of sublimation of solid compound can be found using the values of solution enthalpy and solvation enthalpy in any solvent. In this work enthalpies of solution at infinite dilution of a number of aromatic hydrocarbons derivatives in benzene were measured at 298.15 K. Comparison between experimental and literature solution enthalpies in benzene at 298.15 K and fusion enthalpies at melting temperature of aromatic hydrocarbon derivatives showed, that these values are approximately equal. Thereby, fusion enthalpies at melting temperature can be used instead of their solution enthalpies in benzene at 298.15 K for calculation of sublimation enthalpies at 298.15 K. Solvation enthalpies in benzene at 298.15 K required for this procedure were calculated using group additivity scheme. The sublimation enthalpies of 80 aromatic hydrocarbons derivatives at 298.15 K were evaluated as a difference between fusion enthalpies at melting temperature and solvation enthalpies in benzene at 298.15 K. Obtained in this work values of sublimation enthalpy at 298.15 K for studied compounds were in a good agreement with available literature data

New method for determination of vaporization and sublimation enthalpy of aromatic compounds at 298.15 K using solution calorimetry technique and group-additivity scheme

© 2015 Elsevier B.V. All rights reserved. In this work a new method for determination of vaporization/sublimation enthalpies of aromatic compounds directly at T = 298.15 K was developed. This method is based on the general relationship between vaporization/sublimation enthalpy and enthalpies of solution and solvation of the studied compound in any solvent. According to this method the procedure for determination of vaporization (liquids) or sublimation (solids) enthalpy includes measurement of the solution enthalpy of the compound in a selected solvent and calculation of the solvation enthalpy for this system. A group-additivity scheme for calculation of solvation enthalpies is proposed. The solvation enthalpy of compound is estimated from the solvation enthalpy of parent aromatic or heteroaromatic compound and contributions of the substituent groups. Limiting solution enthalpies of 34 aromatic compounds (substituted benzenes, naphthalenes, biphenyls, pyrene, anthracene and pyridines) in carbon tetrachloride, benzene, acetonitrile and N,N-dimethylformamide were measured in the present work at 298.15 K. Vaporization/sublimation enthalpies of 78 aromatic and heteroaromatic compounds were determined directly at 298.15 K using experimentally measured solution enthalpies and predicted values of solvation enthalpies. The results are in good agreement with available literature data

Synthesis and properties of chiral nanoparticles based on (pS)- and (pR)-decasubstituted pillar[5]arenes containing secondary amide fragments

© The Royal Society of Chemistry 2016.Employing induced asymmetric synthesis, new decasubstituted pillar[5]arenes containing (R)-(+)- or (S)-(-)-1-phenylethane-1-acetamide fragments have been obtained and characterized. Using NTA and TEM, and circular dichroism spectroscopy, it was shown that the amidopillar[5]arenes synthesized form spherical chiral nanoscale aggregates in CHCl3. During heating, both positive and negative Cotton effects corresponding to nanoparticles in CHCl3 reversibly decrease. Keeping the nanoparticles at room temperature results in a decrease in their size and intensification of the Cotton effect

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

© 2017 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer-Medknow.A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950-1050 g/mol and phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters

Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles

© 2017 Elsevier B.V.The work introduces Tb(III)-centered luminescence of amino-modified silica nanoparticles doped with Tb(III) complexes for cellular imaging. For these purposes water-in-oil procedure was optimized for synthesis of 20 and 35 nm luminescent nanoparticles with amino-groups embedded on the surface. The obtained results indicate an impact of the nanoparticle size in decoration, aggregation behavior and luminescent properties of the nanoparticles in protein-based buffer solutions. Formation of a protein-based corona on the nanoparticles surface was revealed through the effect of the nanoparticles on helical superstructure of BSA. This effect is evident from CD spectral data, while no any size impact on the adsorption of BSA onto aminomodified silica surface was observed. Cellular uptake of the nanoparticles studied by confocal and TEM microscopy methods indicates greater cellular uptake for the smaller nanoparticles. Cytotoxicity of the nanoparticles was found to agree well with their cellular uptake behavior, which in turn was found to be greater for the smaller nanoparticles

ОЦЕНКА ЭФФЕКТИВНОСТИ НОВОГО МЕТОДА ЛАПАРОСКОПИЧЕСКОГО ЛЕЧЕНИЯ УЩЕМЛЕННЫХ ПАХОВЫХ И ПАХОВО-МОШОНОЧНЫХ ГРЫЖ У ДЕТЕЙ

Introduction. Congenital inguinal hernia is a common pediatric surgical disease. It is traditionally treated by open herniotomy with high ligation of the hernia sac. To date despite the technical capabilities the incarcerated inguinal and inguinal-scrotal hernias are a contraindication to laparoscopic surgery, and in the available literature there is no information about using endovideolaparoscopic method to treat this pathology in children. In this context, the main objective of this work is to develop a method of laparoscopic treatment of incarcerated inguinal and inguinal-scrotal hernias in children. Materials and methods. The paper presents the results of the diagnosis and laparoscopic treatment of 23 children aged 1 month to 3 years, with incarcerated inguinal and inguinal-scrotal hernias, that has been carried out at the clinic of Pediatric Surgery of BSMU based at City Children Clinical Hospital №17 in UFA in the period 2002-2016  with original method of endovideosurgical dis-incarceration with simultaneous plasty of hernia orifice. Results. According to the results of the analysis the average operation time was 25±4.2 min. The method facilitated early activation and early enteral meal. There were no local complications in aftercare period by trocar wounds, the stitches were removed on the 5th day. The average duration of hospitalization was 6 days. Long-term results through 3 and 6 months have demonstrated the absence of any asymmetry of the groin, tightness of the testicle, increased or reduced testicle volume. Conclusion. Thus, the findings show that laparoscopic hernioplasty for inguinal and inguinal-scrotal hernia, is a new technique and it gives opportunity to solve this problem in children at a whole new level.Введение. Оперативное лечение паховых и пахово-мошоночных грыж является одним из наиболее часто выполняемых хирургических вмешательств у детей. Традиционно при данной патологии выполняется открытая герниотомия с ревизией ущемленных органов, оценкой их жизнеспособности и последующей пластикой грыжевых ворот. Несмотря на наличие технических возможностей на сегодняшний день ущемленные паховые и пахово-мошоночные грыжи являются противопоказанием для лапароскопической операции, а в доступной литературе не обнаружено сведений об использовании эндовидеолапароскопического метода лечения при данной патологии у детей. В этой связи основной целью данной работы является разработка метода лапароскопического лечения ущемленных паховых и пахово-мошоночных грыж у детей. Материалы и методы. В работе представлены результаты диагностики и лапароскопического лечения 23 детей в возрасте от 1 месяца до 3 лет с ущемленными паховыми и пахово-мошоночными грыжами, проведенного в клинике детской хирургии БГМУ на базе ГДКБ № 17 г. Уфы в период 2002-2016 гг оригинально разработанным методом эндовидеохирургического разущемления с одномоментной пластикой грыжевых ворот. Результаты. По результатам проведенного анализа установлено, что средняя продолжительность операции составила 25±4,2 мин. Метод способствовал ранней активизации и раннему энтеральному приему пищи. Местных осложнений в послеоперационном периоде со стороны троакарных ран не отмечалось, швы снимали на 5-е сутки. Средняя продолжительность госпитализации составляла 6 суток. Отдаленные результаты через 3 и 6 месяцев показали отсутствие какой-либо асимметрии паховой области, подтянутости яичка, увеличения или уменьшения объема яичка. Заключение. Таким образом установлено, что лапароскопическая герниопластика при ущемленных паховых и пахово-мошоночных грыжах является новой технологией и дает возможность решать данную проблему у детей на качественно новом, современном уровне

Information technologies in organization of medical aid to patients with vascular diseases of the brain

The article presents results of the implementation activities in the hospital №18 of Ufa with a 'Program monitoring rendering of medical aid to patients with vascular diseases of the brain', which is part of the Unified medical information system. The program is compatible with hospital register primary vascular Department and allows you to optimize continuity in the monitoring patients at all stages of medical care.В статье представлены результаты внедрения в деятельность больницы №18 г. Уфы «Программы мониторинга оказания медицинской помощи пациентам с сосудистыми заболеваниями головного мозга», входящей в состав Единой медицинской информационной системы. Программа совместима с госпитальным регистром первичного сосудистого отделения и позволяет оптимизировать преемственность в наблюдении за пациентами на всех этапах оказания медицинской помощи

Formation of microspherical particles of albumin with model drug using spray drying process

© 2019, AMG Transcend Association. All rights reserved. Spray drying method enables to produce microspherical particles with narrow size distribution. Production of such microparticles is relevant for the development of the advanced systems for inhalation delivery of drugs. The aerosol particles diameter must be between 1 and 3 μm. Composite microparticles based on bovine serum albumin and model drug phenacetin were produced in the present work using the spray-drying method. The absence of a crystalline phase of the drug in composite microparticles was verified using several physicochemical methods. The average radius of the produced microparticles was found to be 1 μm based on the results from scanning electron microscopy. The rate of the dissolution of the drug included in microparticles is faster than that of crystalline phenacetin. The obtained results can be used for the development of the method for preparation of composite microparticles based on protein molecules using the spray-drying technique

Formation of microspherical particles of albumin with model drug using spray drying process

© 2019, AMG Transcend Association. All rights reserved. Spray drying method enables to produce microspherical particles with narrow size distribution. Production of such microparticles is relevant for the development of the advanced systems for inhalation delivery of drugs. The aerosol particles diameter must be between 1 and 3 μm. Composite microparticles based on bovine serum albumin and model drug phenacetin were produced in the present work using the spray-drying method. The absence of a crystalline phase of the drug in composite microparticles was verified using several physicochemical methods. The average radius of the produced microparticles was found to be 1 μm based on the results from scanning electron microscopy. The rate of the dissolution of the drug included in microparticles is faster than that of crystalline phenacetin. The obtained results can be used for the development of the method for preparation of composite microparticles based on protein molecules using the spray-drying technique

Enthalpies of fusion and enthalpies of solvation of aromatic hydrocarbons derivatives: Estimation of sublimation enthalpies at 298.15 K

© 2016 Elsevier B.V. All rights reserved.Enthalpy of sublimation of solid compound can be found using the values of solution enthalpy and solvation enthalpy in any solvent. In this work enthalpies of solution at infinite dilution of a number of aromatic hydrocarbons derivatives in benzene were measured at 298.15 K. Comparison between experimental and literature solution enthalpies in benzene at 298.15 K and fusion enthalpies at melting temperature of aromatic hydrocarbon derivatives showed, that these values are approximately equal. Thereby, fusion enthalpies at melting temperature can be used instead of their solution enthalpies in benzene at 298.15 K for calculation of sublimation enthalpies at 298.15 K. Solvation enthalpies in benzene at 298.15 K required for this procedure were calculated using group additivity scheme. The sublimation enthalpies of 80 aromatic hydrocarbons derivatives at 298.15 K were evaluated as a difference between fusion enthalpies at melting temperature and solvation enthalpies in benzene at 298.15 K. Obtained in this work values of sublimation enthalpy at 298.15 K for studied compounds were in a good agreement with available literature data