Zero Casimir Force in Axion Electrodynamics and New Force Search

We point out that there is a stable configuration of metal plates where the Casimir force is vanishing in axion electrodynamics. We consider a concrete setup involving Weyl semimetals, which hosts an axion-like effect on the electromagnetism, towards the measurement of the axionic effect on the Casimir force. Our setup realizes zero Casimir force between metals and may be useful for the search for new force mediated by light particles at the micrometer scale.Comment: 28 pages, 9 figure

Control of the glass-liquid transition temperature in YBa2Cu3O7-x films

Magnetic field dependences of the glass-liquid transition temperature (Tg) were studied in YBa2Cu3O7−x films containing various types of nanoinclusions. The vortex configuration entangled or straight and pinning strength for each vortex are crucial to the behaviors of Tg. c-axis correlated pinning centers optimize these factors and achieve the upper limit of Tg, which is determined by loss of line tension of vortices, if they are elongated through a thickness of a sample. By optimizing pinning centers, critical temperature, and a matching field, a Tg value of 77 K can be obtained in YBa2Cu3O7−x in a magnetic field as high as 27 T

Genetic screening for malignant hyperthermia and comparison of clinical symptoms in Japan

Malignant hyperthermia (MH) is an anaesthetic complication that causes an abnormal hypermetabolic state. RYR1 encoding ryanodine receptors of the sarcoplasmic reticulum and CACNA1S encoding α subunits of dihydropyridine receptors are known to be associated with MH pathogenicity. We performed genetic screening using next-generation sequencing to evaluate the prevalence of genes associated with MH pathogenicity and clinical symptoms. This was a retrospective cohort study wherein next-generation sequencing data of 77 families diagnosed with MH predisposition by calcium-induced calcium release (CICR) tests from 1995 to 2019 was used to search for RYR1 and CACNA1S variants. Furthermore, the clinical symptoms and predisposition tests in participants with RYR1 and CACNA1S variants were compared. In the 77 families, 44.2%, 7.8%, and 48.1% individuals had RYR1, CACNA1S, and neither RYR1 nor CACNA1S variants, respectively. Clinically significant differences were found in the maximum body temperature, maximum elevated body temperature for 15 min, creatinine kinase level, and CICR rate between the RYR1 and CACNA1S groups. The prevalence of pathogenic CACNA1S variants appears to be prominent in Japan. The severity of clinical symptoms and the CICR rate were greater in individuals with RYR1 variants than in those with CACNA1S variants, likely due to more direct regulation of calcium levels by ryanodine receptors than by dihydropyridine receptors. Genetic analysis of MH in future studies may help identify other genes associated with MH, which will further clarify the relationship between genotypes and MH symptoms and contribute to safer anaesthesia practice.This study was supported by a Grant-in-Aid for Young Scientists (grant number: 17K16733 to Y.N. and 20K17783 to R.K.) from the Japan Society for the Promotion of Science and by the Takeda Science Foundation (H.K.)