7 research outputs found
Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction
Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans
TLR2 and TLR4 differentially regulate B7-1 resulting in distinct cytokine responses to the mycoplasma superantigen MAM as well as to disease induced by Mycoplasma arthritidis
Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vaculoar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization
Structural Basis of Pattern Recognition by Innate Immune Molecules
The importance of the innate immune system as a first line defence against pathogenic challenge has long been recognised. Over the last decade the identity of many of the key molecules mediating innate host defence have been clarified and a model of self/nonself discrimination by families of pattern recognition receptors (PRRs) has emerged. Although a large amount of information is now available concerning the action of these innate immune molecules at the level of the cell and organism, little is known about the molecular interface between pathogens and innate immune recognition molecules. In this chapter the molecular basis for innate immune discrimination of a wide variety of pathogen derived molecules is discussed in the context of the emerging literature