Analisis Biaya Satuan (Unit Cost) Perjenis Tindakan Berdasarkan Relative Value Unit (Rvu) pada Bagian Persalinan RSUD Ajjapange Kabupaten Soppeng Tahun 2011

This study aimed to obtain information concerning the unit cost used in Obstetric and gynecology Unit at Ajjapange Hospital, Soppeng District, 2011. This type of research is quantitative research using a descriptive survey method. The population is all the result of financial transactions in the Ajjapange Hospital, Soppeng District which has been differentiated with production units and supporting units. The sample in this study were all the result of financial transactions related to fixed cost, semi-variable costs and variable costs in cost centers, both centers of production costs and central support unit labor costs in obstetric and gynecology Unit at Ajjapange Hospital, Soppeng District, 2011. The results showed that the unit cost based on Relative Value Unit with TC III is to act normal deliveries which the price is Rp 467,922, pathological labor action (A) is Rp 1,065,651, labor actions pathological (B) is Rp 1,406,075, Cesaria secsio action is Rp 2,878,136, action curettage (retersi placenta, placental rest, manual placenta, hydatidiform mole) are Rp 615,457, action curettage (abortion PUD) is Rp 514,625 and curettage with anesthetic action is Rp 1,392,266. The recommendation is to set cost in a rational way at obstetric and gynecology unit for each type of intervention. The method could use unit costs analysis based on the Relative Value Unit (RVU) and based on the Ability To Pay and Willingness To Pay of the society. Keywords : unit cost, relative value unit (RVU), obstetric and gynecology unit, hospita

Pemetaan Preferensi Mahasiswa Baru Dalam Memilih Jurusan Menggunakan Artificial Neural Network (Ann) Dengan Algoritma Self Organizing Maps (Som)

College is the highest educational institution and the role the intellectual life of the Indonesian people that the main purpose of academics. Not all colleges into their destination but only college that has a role, credibility and rank the best course of which it is their goal. This makes higher education marketing research approach to get attention and become the main goal of the academics in choosing a college. This research was conducted in order to determine with certainty attribute / emotional reasons academics in choosing college as their academic goals. The method used in this study were self-organizing maps with the Kohonen algorithm is a classification method. Kohonen SOM algorithm with learning rate used 0:05, 0.25, 0:50, 0.75, 0.95 and initialization of initial weight value and the value of the midpoint and 500 iterations with output 3 clusters are formed. Results clustering of SOM validated using Davies-Bouldin index with the best clustering results that DBI minimum (1.7802) with the learning rate is 0.95 and the cluster formed three clusters for the first cluster as many as six members, cluster-2 by 9 members and 3rd cluster as 5 members the results of clustering with top priority contained in the cluster to-2 with a mean (7.434) with the characteristics of each member is an emotional reason in choosing a major

Pengaruh Pengalaman Kerja, Otonomi Kerja, Dan Tekanan Peran Terhadap Kinerja Auditor Pada Kantor Akuntan Publik Di Bandar Lampung (Study Kasus Pada Kantor Akuntan Publik Di Bandar Lampung)

Public Accounting Firm (KAP) is a form of organization that has licensed public accountant in accordance with legislation that seeks the provision of professional services in the field of public accounting practice. CPAs function as an external audit will be effective and optimal performance if supported by auditors. To improve the performance of an auditor, not only requires only intellectual, but also needed a good work experience, freedom and independence in carrying out the duties and powers of office for each professional. Method of data collection is by using questionnaires distributed to the auditor in public accounting firm in Bandar Lampung, while the analytical tools used are qualitative analysis and quantitative analysis. The results showed that work experience and job autonomy positive and significant impact on the performance of auditors, while the role of pressure and a significant negative effect on the performance of auditors. Based on the above conclusion, it is suggested that public accounting firm auditors to limit the amount of workload and provide clear information to avoid conflicts and role

Grand Desain Simulasi Bencana Merapi 2014 Solusi Perencanaan Dan Pengelolaan Aspek Kesehatan Masyarakat Pengungsi

Saat terjadi bencana selalu terjadi kedaruratan disemua aspek kehidupan. Bencana menimbulkan korban jiwa manusia, kerusakan lingkungan, kerugian harta benda, dan dampak psikologis. Aspek kesehatan menjadi hal utama selama tinggal di pengungsian. Dampak yang sangat menonjol dari segi kesehatan di pengungsian bencana Merapi adalah merebaknya penyakit kulit dan batuk-batuk. Bantuan hidup dasar juga sangat dibutuhkan oleh para pengungsi. Kebutuhan air bersih, MCK, sanitasi, gizi dan bilik asmara perlu disediakan untuk para pengungsi. Untuk memperoleh jumlah perkiraan pengungsi Merapi pada tahun 2014 dan perhitungan jumlah kebutuhan dasar pengungsi yang tercetak dalam sebuah buku panduan yang disebut Grand Desain sedangkan metode yang digunakan didasarkan pada proyeksi penduduk untuk memperkirakan jumlah orang yang akan mengungsi di wilayah KRB Merapi Regional Jawa Tengah dan menghitung kebutuhan dasar pengungsi dari aspek kesehatan masyarakat pengungsi secara fisiologis. Dengan menggunakan rumus proyeksi penduduk diperoleh jumlah perkiraan pengungsi di KRB Merapi Jawa Tengah pada tahun 2014 sebanyak 319.126 jiwa. Jumlah kebutuhan dasar pengungsi yang harus dipenuhi mencakup kebutuhan air bersih, gizi, MCK, sanitasi dan persampahan, serta kebutuhan bilik asmara. Sebanyak 319.126 jiwa pengungsi membutuhkan setidaknya 6.382.520 liter air bersih per hari untuk keperluan memasak, makan, minum. Kebutuhan MCK setidaknya membutuhkan 6.383 sampai 12.764 buah MCK. Kebutuhan gizi pengungsi Merapi mencakup setidaknya 127.650 ton beras per hari dan diperkirakan pula akan dihasilkan jumlah timbulan sampah dipengungsian sebanyak 638,3 m3 per hari. Tingginya jumlah timbulan sampah membutuhkan setidaknya 80 truk pengangkut sampah per hari untuk mengangkut sampah keluar dari tempat pengungsi

Intronic Alus Influence Alternative Splicing

Examination of the human transcriptome reveals higher levels of RNA editing than in any other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) formation within the human transcriptome. Most of the editing sites are located in the primate-specific retrotransposed element called Alu. A large fraction of Alus are found in intronic sequences, implying extensive Alu-Alu dsRNA formation in mRNA precursors. Yet, the effect of these intronic Alus on splicing of the flanking exons is largely unknown. Here, we show that more Alus flank alternatively spliced exons than constitutively spliced ones; this is especially notable for those exons that have changed their mode of splicing from constitutive to alternative during human evolution. This implies that Alu insertions may change the mode of splicing of the flanking exons. Indeed, we demonstrate experimentally that two Alu elements that were inserted into an intron in opposite orientation undergo base-pairing, as evident by RNA editing, and affect the splicing patterns of a downstream exon, shifting it from constitutive to alternative. Our results indicate the importance of intronic Alus in influencing the splicing of flanking exons, further emphasizing the role of Alus in shaping of the human transcriptom

Trapping of Intermediates with Substrate Analog HBOCaA in the Polymerizations Catalyzer by Class III Polyhydroxybutyrate (PHB) Synthase from Allochromatium Vinosum

Polyhydroxybutyrate (PHB) synthases (PhaCs) catalyze the formation of biodegradable PHB polymers that are considered as an ideal alternative to petroleum-based plastics. To provide strong evidence for the preferred mechanistic model involving covalent and noncovalent intermediates, a substrate analog HBOCoA was synthesized chemoenzymatically. Substitution of sulfur in the native substrate HBCoA with an oxygen in HBOCoA enabled detection of (HB)nOCoA (n = 2–6) intermediates when the polymerization was catalyzed by wild-type (wt-)PhaECAv at 5.84 hr−1. This extremely slow rate is due to thermodynamically unfavorable steps that involve formation of enzyme-bound PHB species (thioesters) from corresponding CoA oxoesters. Synthesized standards (HB)nOCoA (n = 2–3) were found to undergo both reacylation and hydrolysis catalyzed by the synthase. Distribution of the hydrolysis products highlights the importance of the penultimate ester group as previously suggested. Importantly, the reaction between primed synthase [3H]-sT-PhaECAv and HBOCoA yielded [3H]-sTet-O-CoA at a rate constant faster than 17.4 s−1, which represents the first example that a substrate analog undergoes PHB chain elongation at a rate close to that of the native substrate (65.0 s−1). Therefore, for the first time with a wt-synthase, strong evidence was obtained to support our favored PHB chain elongation model

Inhibition of Biofilm Formation, Quorum Sensing and Infection in Pseudomonas aeruginosa by Natural Products-Inspired Organosulfur Compounds

Using a microplate-based screening assay, the effects on Pseudomonas aeruginosa PAO1 biofilm formation of several S-substituted cysteine sulfoxides and their corresponding disulfide derivatives were evaluated. From our library of compounds, S-phenyl-L-cysteine sulfoxide and its breakdown product, diphenyl disulfide, significantly reduced the amount of biofilm formation by P. aeruginosa at levels equivalent to the active concentration of 4-nitropyridine-N-oxide (NPO) (1 mM). Unlike NPO, which is an established inhibitor of bacterial biofilms, our active compounds did not reduce planktonic cell growth and only affected biofilm formation. When used in a Drosophila-based infection model, both S-phenyl-L-cysteine sulfoxide and diphenyl disulfide significantly reduced the P. aeruginosa recovered 18 h post infection (relative to the control), and were non-lethal to the fly hosts. The possibility that the observed biofilm inhibitory effects were related to quorum sensing inhibition (QSI) was investigated using Escherichia coli-based reporters expressing P. aeruginosa lasR or rhIR response proteins, as well as an endogenous P. aeruginosa reporter from the lasI/lasR QS system. Inhibition of quorum sensing by S-phenyl-L-cysteine sulfoxide was observed in all of the reporter systems tested, whereas diphenyl disulfide did not exhibit QSI in either of the E. coli reporters, and showed very limited inhibition in the P. aeruginosa reporter. Since both compounds inhibit biofilm formation but do not show similar QSI activity, it is concluded that they may be functioning by different pathways. The hypothesis that biofilm inhibition by the two active compounds discovered in this work occurs through QSI is discussed

Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm

We present a new measurement of the positive muon magnetic anomaly, a_{μ}≡(g_{μ}-2)/2, from the Fermilab Muon g-2 Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our previous result from 2018 data. The systematic error is reduced by more than a factor of 2 due to better running conditions, a more stable beam, and improved knowledge of the magnetic field weighted by the muon distribution, ω[over ˜]_{p}^{'}, and of the anomalous precession frequency corrected for beam dynamics effects, ω_{a}. From the ratio ω_{a}/ω[over ˜]_{p}^{'}, together with precisely determined external parameters, we determine a_{μ}=116 592 057(25)×10^{-11} (0.21 ppm). Combining this result with our previous result from the 2018 data, we obtain a_{μ}(FNAL)=116 592 055(24)×10^{-11} (0.20 ppm). The new experimental world average is a_{μ}(exp)=116 592 059(22)×10^{-11} (0.19 ppm), which represents a factor of 2 improvement in precision