Near-infrared wavelength intersubband transitions in GaN∕AlN short period superlattices

Intersubband transitions in GaN∕AlN short period superlattices prepared by molecular beam epitaxy were investigated using the optical absorption technique. The peak position wavelengths of these transitions are found to span the spectral range of 1.35–2.90μm for samples cut into 45° waveguides with GaNquantum well thicknesses ranging between 1.70 and2.41nm. The Fermi energy levels are estimated from the carrier concentrations, which were measured using an electrochemical capacitance-voltage profiler. The well widths were inferred from comparing the measured peak position energy of the intersubband transitions and the bound state energy levels calculated using the transfer matrix method

The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.

TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3'UTR of TNFAIP2 and gastric cancer risk in a US population.We conducted a case-control study of 301 gastric cancer patients and 313 cancer-free controls frequency-matched by age, sex and ethnicity. We genotyped four selected TNFAIP2 SNPs (rs8126 T>C, rs710100 G>A, rs1052912 G>A and rs1052823 G>T) and used the logistic regression analysis to assess associations of these SNPs with cancer risk.The rs8126 CC genotype was associated with a significantly elevated risk of gastric cancer (adjusted OR = 2.00, 95% CI = 1.09-3.64 and P = 0.024), compared with the combined rs8126 TT+TC genotypes, particularly in current drinkers. However, none of other TNFAIP2 SNPs was associated with risk of gastric cancer.Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies

Stratification analysis for associations between the <i>TNFAIP2</i> rs8126 SNP and gastric cancer risk.

a<p>Adjusted for age, sex, race, smoking status and drinking status.</p>b<p>Information of drinking status was unavailable for 3 cases.</p><p>(Statistically significant findings are in bold).</p

Distributions of selected variables in gastric cancer cases and cancer-free controls.

a<p>Two-sided χ² test.</p>b<p>Information of smoking and drinking status was unavailable for 3 cases.</p

The four selected SNPs of <i>TNFAIP2</i>.

<p>(A) The four validated SNPs and their exact locations within the <i>TNFAIP2</i> 3′-UTR. (B) Linkage disequilibrium (LD) map for selected SNPs of <i>TNFAIP2</i> gene. It showed that rs1052912 and rs1052823 are in LD with a D′ = 0.87.</p

Logistic regression analysis of associations between the genotypes of <i>TNFAIP2</i> and gastric cancer risk.

a<p>Adjusted for age, sex, race, smoking status and drinking status.</p><p>(Statistically significant findings are in bold).</p

Haplotype analysis for genotypes of <i>TNFAIP2</i> and Gastric Cancer risk.

a<p>The order of haplotype sequence is rs8126, rs1052823 and rs710100.</p><p>Adjusted for age, sex, race, smoking status and drinking status.</p><p>(Statistically significant findings are in bold).</p