1 research outputs found
Synthesis of Hollow Biomineralized CaCO<sub>3</sub>–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity
The
development of activatable nanoplatforms to simultaneously
improve diagnostic and therapeutic performances while reducing side
effects is highly attractive for precision cancer medicine. Herein,
we develop a one-pot, dopamine-mediated biomineralization method using
a gas diffusion procedure to prepare calcium carbonate-polydopamine
(CaCO<sub>3</sub>–PDA) composite hollow nanoparticles as a
multifunctional theranostic nanoplatform. Because of the high sensitivity
of such nanoparticles to pH, with rapid degradation under a slightly
acidic environment, the photoactivity of the loaded photosensitizer,
i.e., chlorin e6 (Ce6), which is quenched by PDA, is therefore increased
within the tumor under reduced pH, showing recovered fluorescence
and enhanced singlet oxygen generation. In addition, due to the strong
affinity between metal ions and PDA, our nanoparticles can bind with
various types of metal ions, conferring them with multimodal imaging
capability. By utilizing pH-responsive multifunctional nanocarriers,
effective in vivo antitumor photodynamic therapy (PDT) can be realized
under the precise guidance of multimodal imaging. Interestingly, at
normal physiological pH, our nanoparticles are quenched and show much
lower phototoxicity to normal tissues, thus effectively reducing skin
damage during PDT. Therefore, our work presents a unique type of biomineralized
theranostic nanoparticles with inherent biocompatibility, multimodal
imaging functionality, high antitumor PDT efficacy, and reduced skin
phototoxicity