10 research outputs found
Temporal and spatial distribution of the Wufeng Formation black shales (Upper Ordovician) in South China
Geographic dynamics of some major graptolite taxa of the Diplograptina during the Late Ordovician mass extinction in South China
Geobiodiversity Database (GBDB) in stratigraphic, palaeontological and palaeogeographic research: graptolites as an example
Internal supporting structures of some Late Ordovician graptolites from South China revealed by micro‐CT
Triassic palynostratigraphy and palynofloral provinces: evidence from southern Xizang (Tibet), China
Palynological analysis was carried out on Middle to Upper Triassic strata from Tulong, Nyalam County, southern Xizang (Tibet), China. Well-preserved miospore (pollen and spore) assemblages and sparse acritarch occurrences were identified. We recognized four formal and one informal biozones based on stratigraphically important taxa and compositional changes through the succession, in ascending order: the Triplexisporites Interval Zone (Anisian), the Staurosaccites quadrifidus Taxon-range Zone (upper Anisian to lower Norian), the Striatella Interval Zone (lower Norian), the Craterisporites rotundus Taxon-range Zone (middle to upper Norian) and the informal ‘Dictyophyllidites harrisii zone’ (Rhaetian). The zonation was supported by marine fossils (e.g., ammonoids and conodonts), and compositional similarity between the zones was examined using non-metric multidimensional scaling (NMDS). Correlation with other representative palynological sequences across Gondwana was also conducted. The presence of miospore taxa not previously recovered from the Late Triassic North and South China palynofloral provinces (e.g., Ashmoripollis reducta, Craterisporites rotundus, Enzonalasporites vigens, Minutosaccus crenulatus, Samaropollenites speciosus and Staurosaccites quadrifidus) calls for a new province in southwestern China, i.e., the Southern Xizang Province. It is proposed here that the modern expression of the northern boundary runs along the Yarlung Zangbo Suture, the remnant of the Tethys that separated the Indian Plate (southern Xizang) and the Lhasa Block during the Late Triassic. This new palynofloral province comprises typical elements of the Onslow Microflora, indicating the need for an extension of this microflora in southern Xizang, China.This work was made possible by the support of the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB03010103), UNESCO grant IGCP 632, the Swedish Research Council, grant VR 2015-04264 and the China Scholarship Council (201504910609).</p
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant intra-tumoral B to plasma cell differentiation in lymphoid aggregates in MBM. MBM harbored larger fractions of monocyte-derived macrophages and dysfunctional TOX <sup>+</sup> CD8 <sup>+</sup> T cells with distinct expression of immune checkpoints. This work provides comprehensive insights into MBM biology and serves as a foundational resource for further discovery and therapeutic exploration